(Q28595098)

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RNA-binding protein is involved in aggregation of light neurofilament protein and is implicated in the pathogenesis of motor neuron degeneration

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PubMed publication ID

1 February 2017

RNA-binding protein is involved in aggregation of light neurofilament protein and is implicated in the pathogenesis of motor neuron degeneration (English)

1 reference

PubMed publication ID

1 February 2017

1 reference

based on heuristic

inferred from title

Rho guanine nucleotide exchange factor (GEF) 28

1 reference

GOA release 2020-03-11

Neurofilament, light polypeptide

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GOA release 2020-03-11

RNA-binding proteins

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based on heuristic

inferred from title

author name string

Hong Lin

1

1 reference

PubMed publication ID

1 February 2017

Jinbin Zhai

2

1 reference

PubMed publication ID

1 February 2017

William W. Schlaepfer

3

1 reference

PubMed publication ID

1 February 2017

publication date

1 December 2005

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PubMed publication ID

1 February 2017

Human Molecular Genetics

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PubMed publication ID

1 February 2017

14

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PubMed publication ID

1 February 2017

23

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PubMed publication ID

1 February 2017

3643–3659

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PubMed publication ID

1 February 2017

Human prion diseases: molecular and clinical aspects

1 reference

https://api.crossref.org/works/10.1093/HMG/DDI392

21 January 2018

Protein aggregation and neurodegenerative disease

1 reference

https://api.crossref.org/works/10.1093/HMG/DDI392

21 January 2018

Neurodegenerative diseases caused by protein aggregation: a phenomenon at the borderline between molecular evolution and ageing.

1 reference

https://api.crossref.org/works/10.1093/HMG/DDI392

21 January 2018

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

1 reference

https://api.crossref.org/works/10.1093/HMG/DDI392

21 January 2018

Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders.

1 reference

https://api.crossref.org/works/10.1093/HMG/DDI392

21 January 2018

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

1 reference

https://api.crossref.org/works/10.1093/HMG/DDI392

21 January 2018

Pathways to motor neuron degeneration in transgenic mouse models

1 reference

https://api.crossref.org/works/10.1093/HMG/DDI392

21 January 2018

Amyotrophic lateral sclerosis mutations have the greatest destabilizing effect on the apo- and reduced form of SOD1, leading to unfolding and oxidative aggregation.

1 reference

https://api.crossref.org/works/10.1093/HMG/DDI392

21 January 2018

Systematically perturbed folding patterns of amyotrophic lateral sclerosis (ALS)-associated SOD1 mutants

1 reference

https://api.crossref.org/works/10.1093/HMG/DDI392

21 January 2018

Dimer destabilization in superoxide dismutase may result in disease-causing properties: structures of motor neuron disease mutants.

1 reference

https://api.crossref.org/works/10.1093/HMG/DDI392

21 January 2018

The rate and equilibrium constants for a multistep reaction sequence for the aggregation of superoxide dismutase in amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1093/HMG/DDI392

21 January 2018

Folding of human superoxide dismutase: disulfide reduction prevents dimerization and produces marginally stable monomers

1 reference

https://api.crossref.org/works/10.1093/HMG/DDI392

21 January 2018

Monomeric Cu,Zn-superoxide dismutase is a common misfolding intermediate in the oxidation models of sporadic and familial amyotrophic lateral sclerosis.

1 reference

https://api.crossref.org/works/10.1093/HMG/DDI392

21 January 2018

Misfolded CuZnSOD and amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1093/HMG/DDI392

21 January 2018

Minute quantities of misfolded mutant superoxide dismutase-1 cause amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1093/HMG/DDI392

21 January 2018

Molecular genetics of distal hereditary motor neuropathies

1 reference

https://api.crossref.org/works/10.1093/HMG/DDI392

21 January 2018

Stability determinants are localized to the 3'-untranslated region and 3'-coding region of the neurofilament light subunit mRNA using a tetracycline-inducible promoter

1 reference

https://api.crossref.org/works/10.1093/HMG/DDI392

21 January 2018

3' untranslated region in a light neurofilament (NF-L) mRNA triggers aggregation of NF-L and mutant superoxide dismutase 1 proteins in neuronal cells.

1 reference

https://api.crossref.org/works/10.1093/HMG/DDI392

21 January 2018

p190RhoGEF Binds to a destabilizing element in the 3' untranslated region of light neurofilament subunit mRNA and alters the stability of the transcript

1 reference

https://api.crossref.org/works/10.1093/HMG/DDI392

21 January 2018

Decreased neurofilament gene expression is an index of selective axonal hypotrophy in ageing.

1 reference

https://api.crossref.org/works/10.1093/HMG/DDI392

21 January 2018

Initiation and Synergistic Fibrillization of Tau and Alpha-Synuclein

1 reference

https://api.crossref.org/works/10.1093/HMG/DDI392

21 January 2018

Absence of neurofilaments reduces the selective vulnerability of motor neurons and slows disease caused by a familial amyotrophic lateral sclerosis-linked superoxide dismutase 1 mutant

1 reference

https://api.crossref.org/works/10.1093/HMG/DDI392

21 January 2018

Neurofilament-deficient axons and perikaryal aggregates in viable transgenic mice expressing a neurofilament-beta-galactosidase fusion protein

1 reference

https://api.crossref.org/works/10.1093/HMG/DDI392

21 January 2018

Pathogenesis of two axonopathies does not require axonal neurofilaments.

1 reference

https://api.crossref.org/works/10.1093/HMG/DDI392

21 January 2018

A mutant neurofilament subunit causes massive, selective motor neuron death: implications for the pathogenesis of human motor neuron disease

1 reference

https://api.crossref.org/works/10.1093/HMG/DDI392

21 January 2018

Assembly of type IV neuronal intermediate filaments in nonneuronal cells in the absence of preexisting cytoplasmic intermediate filaments

1 reference

https://api.crossref.org/works/10.1093/HMG/DDI392

21 January 2018

Purification of individual components of the neurofilament triplet: filament assembly from the 70 000-dalton subunit

1 reference

https://api.crossref.org/works/10.1093/HMG/DDI392

21 January 2018

Self-assembly in Vitro of the 68,000 molecular weight component of the mammalian neurofilament triplet proteins into intermediate-sized filaments

1 reference

https://api.crossref.org/works/10.1093/HMG/DDI392

21 January 2018

Interaction of c-Jun amino-terminal kinase interacting protein-1 with p190 rhoGEF and its localization in differentiated neurons

1 reference

https://api.crossref.org/works/10.1093/HMG/DDI392

21 January 2018

Aldolases a and C are ribonucleolytic components of a neuronal complex that regulates the stability of the light-neurofilament mRNA.

1 reference

https://api.crossref.org/works/10.1093/HMG/DDI392

21 January 2018

Identifiers

10.1093/HMG/DDI392

1 reference

PubMed publication ID

1 February 2017

PubMed publication ID

1 reference

PubMed publication ID

1 February 2017

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