(Q28285094)

Mitochondrial defects in cancer

21 April 2017

1 reference

Architecture of succinate dehydrogenase and reactive oxygen species generation

21 April 2017

1 reference

Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma

21 April 2017

1 reference

A role for mitochondrial enzymes in inherited neoplasia and beyond

21 April 2017

1 reference

Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase

21 April 2017

1 reference

Mutations in the fumarate hydratase gene cause hereditary leiomyomatosis and renal cell cancer in families in North America

21 April 2017

1 reference

Distinct clinical features of paraganglioma syndromes associated with SDHB and SDHD gene mutations

21 April 2017

1 reference

Disruption of mitochondrial function during apoptosis is mediated by caspase cleavage of the p75 subunit of complex I of the electron transport chain

21 April 2017

1 reference

Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer

21 April 2017

1 reference

Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak

21 April 2017

1 reference

A HIF1alpha regulatory loop links hypoxia and mitochondrial signals in pheochromocytomas

21 April 2017

1 reference

Targeting HIF-1 for cancer therapy

21 April 2017

1 reference

The mitochondrial transporter family (SLC25): physiological and pathological implications

21 April 2017

1 reference

Hypoxia--a key regulatory factor in tumour growth

21 April 2017

1 reference

HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability

21 April 2017

1 reference

Akt stimulates aerobic glycolysis in cancer cells

21 April 2017

1 reference

Oxygen sensing by HIF hydroxylases

21 April 2017

1 reference

Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing

21 April 2017

1 reference

On the Origin of Cancer Cells

21 April 2017

1 reference

Somatic mutations of the mitochondrial genome in human colorectal tumours

31 March 2020

1 reference

High frequency of homoplasmic mitochondrial DNA mutations in human tumors can be explained without selection

31 March 2020

1 reference

mtDNA mutations increase tumorigenicity in prostate cancer

31 March 2020

1 reference

Positive contribution of pathogenic mutations in the mitochondrial genome to the promotion of cancer by prevention from apoptosis

31 March 2020

1 reference

Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma

31 March 2020

1 reference

Mutations in SDHC cause autosomal dominant paraganglioma, type 3.

31 March 2020

1 reference

Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer

31 March 2020

1 reference

Inherited susceptibility to uterine leiomyomas and renal cell cancer

31 March 2020

1 reference

On the association of succinate dehydrogenase mutations with hereditary paraganglioma

31 March 2020

1 reference

The TCA cycle and tumorigenesis: the examples of fumarate hydratase and succinate dehydrogenase.

31 March 2020

1 reference

Direct evidence for expression of type II flavoprotein subunit in human complex II (succinate-ubiquinone reductase).

31 March 2020

1 reference

Direct evidence for two distinct forms of the flavoprotein subunit of human mitochondrial complex II (succinate-ubiquinone reductase).

31 March 2020

1 reference

Genetic and functional analyses of FH mutations in multiple cutaneous and uterine leiomyomatosis, hereditary leiomyomatosis and renal cancer, and fumarate hydratase deficiency

31 March 2020

1 reference

Nearly all hereditary paragangliomas in the Netherlands are caused by two founder mutations in the SDHD gene

31 March 2020

1 reference

Large germline deletions of mitochondrial complex II subunits SDHB and SDHD in hereditary paraganglioma

31 March 2020

1 reference

An Alu-mediated partial SDHC deletion causes familial and sporadic paraganglioma

31 March 2020

1 reference

Familial multiple cutaneous and uterine leiomyomas associated with papillary renal cell cancer.

31 March 2020

1 reference

SDHD mutations in head and neck paragangliomas result in destabilization of complex II in the mitochondrial respiratory chain with loss of enzymatic activity and abnormal mitochondrial morphology.

31 March 2020

1 reference

A novel succinate dehydrogenase subunit B gene mutation, H132P, causes familial malignant sympathetic extraadrenal paragangliomas.

31 March 2020

1 reference

Succinate dehydrogenase and human diseases: new insights into a well-known enzyme

31 March 2020

1 reference

Early-onset renal cell carcinoma as a novel extraparaganglial component of SDHB-associated heritable paraganglioma

31 March 2020

1 reference

Germline SDHD mutation in familial phaeochromocytoma

31 March 2020

1 reference

Prevalence of SDHB, SDHC, and SDHD germline mutations in clinic patients with head and neck paragangliomas

31 March 2020

1 reference

Germ-line mutations in nonsyndromic pheochromocytoma

31 March 2020

1 reference

Novel succinate dehydrogenase subunit B (SDHB) mutations in familial phaeochromocytomas and paragangliomas, but an absence of somatic SDHB mutations in sporadic phaeochromocytomas

31 March 2020

1 reference

Clinical characteristics of pheochromocytoma patients with germline mutations in SDHD.

31 March 2020

1 reference

SDHB, SDHC, and SDHD mutation screen in sporadic and familial head and neck paragangliomas

31 March 2020

1 reference

Germline SDHD mutation in paraganglioma of the spinal cord

31 March 2020

1 reference

Evidence of increased microvessel density and activation of the hypoxia pathway in tumours from the hereditary leiomyomatosis and renal cell cancer syndrome

31 March 2020

1 reference

Biallelic inactivation of fumarate hydratase (FH) occurs in nonsyndromic uterine leiomyomas but is rare in other tumors

31 March 2020

1 reference

No germline FH mutations in familial breast cancer patients

31 March 2020

1 reference

Molecular genetic analysis of FIH-1, FH, and SDHB candidate tumour suppressor genes in renal cell carcinoma

31 March 2020

1 reference

Mitochondria: releasing power for life and unleashing the machineries of death

31 March 2020

1 reference

Dynamics of mitochondrial morphology in healthy cells and during apoptosis

31 March 2020

1 reference

Cell biology: metabolism meets death

31 March 2020

1 reference

The tumor suppressor cybL, a component of the respiratory chain, mediates apoptosis induction

31 March 2020

1 reference

Multifaceted roles of glycolytic enzymes.

31 March 2020

1 reference

Reactive oxygen species in tumor progression

31 March 2020

1 reference

HIF-1 and tumor progression: pathophysiology and therapeutics

31 March 2020

1 reference

HIFs, hypoxia, and vascular development

31 March 2020

1 reference

Pheochromocytoma and functional paraganglioma.

31 March 2020

1 reference

Regulation of oxygen sensing by ion channels.

31 March 2020

1 reference

Altitude is a phenotypic modifier in hereditary paraganglioma type 1: evidence for an oxygen-sensing defect

31 March 2020

1 reference

Genomic imprinting and environment in hereditary paraganglioma

31 March 2020

1 reference

Functional consequences of a SDHB gene mutation in an apparently sporadic pheochromocytoma

31 March 2020

1 reference

Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations

31 March 2020

1 reference

Role of VHL gene mutation in human cancer

31 March 2020

1 reference

von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF.

31 March 2020

1 reference

Contrasting effects on HIF-1alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease.

31 March 2020

1 reference

Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance

31 March 2020

1 reference

The hypoxic response of tumors is dependent on their microenvironment.

31 March 2020

1 reference

HIF hydroxylation and the mammalian oxygen-sensing pathway

31 March 2020

1 reference

Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules

31 March 2020

1 reference

JunD reduces tumor angiogenesis by protecting cells from oxidative stress

31 March 2020

1 reference

Endogenous 2-oxoacids differentially regulate expression of oxygen sensors

31 March 2020

1 reference

Mitochondrial signaling: the retrograde response

31 March 2020

1 reference

Cell biology. How cells endure low oxygen

31 March 2020

1 reference

ROS: really involved in oxygen sensing

31 March 2020

1 reference

Mechanism of the Prolyl Hydroxylase Reaction. 2. Kinetic Analysis of the Reaction Sequence

31 March 2020

1 reference

Novel mutations in the SDHD gene in pedigrees with familial carotid body paraganglioma and sensorineural hearing loss

31 March 2020

1 reference

Paragangliomas of the head and neck region show complete loss of heterozygosity at 11 q22-q23 in chief cells and the flow-sorted dna aneuploid fraction

31 March 2020

1 reference

Somatic loss of maternal chromosome 11 causes parent-of-origin-dependent inheritance in SDHD-linked paraganglioma and phaeochromocytoma families.

31 March 2020

1 reference

Mitochondria, oxygen free radicals, disease and ageing

31 March 2020

1 reference

Mechanism of superoxide and hydrogen peroxide formation by fumarate reductase, succinate dehydrogenase, and aspartate oxidase.

31 March 2020

1 reference

Essential role of complex II of the respiratory chain in hypoxia-induced ROS generation in the pulmonary vasculature.

31 March 2020

1 reference

Autosomal dominant malignant and catecholamine-producing paraganglioma caused by a splice donor site mutation in SDHC.

31 March 2020

1 reference