(Q28213222)

7 January 2021

Ubiquitin-mediated proteolysis: biological regulation via destruction

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7 January 2021

Evolution and function of ubiquitin-like protein-conjugation systems

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7 January 2021

Ubiquitin and its kin: how close are the family ties?

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7 January 2021

Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalpha

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7 January 2021

NEDD8 recruits E2-ubiquitin to SCF E3 ligase.

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7 January 2021

Protein modification by SUMO

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7 January 2021

A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2

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7 January 2021

The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases

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7 January 2021

Themes and variations on ubiquitylation

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7 January 2021

SCF and Cullin/Ring H2-based ubiquitin ligases

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7 January 2021

Whose end is destruction: cell division and the anaphase-promoting complex

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7 January 2021

The von Hippel-Lindau tumor suppressor gene

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7 January 2021

U box proteins as a new family of ubiquitin-protein ligases

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7 January 2021

Not such a dismal science: the economics of protein synthesis, folding, degradation and antigen processing

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7 January 2021

Antigen processing by the proteasome

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7 January 2021

NF-kappa B: ten years after

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7 January 2021

NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses

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7 January 2021

Series introduction: the transcription factor NF-kappaB and human disease

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7 January 2021

NF-kappaB signaling pathways in mammalian and insect innate immunity

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7 January 2021

Targeted disruption of the p50 subunit of NF-kappa B leads to multifocal defects in immune responses

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7 January 2021

Chronic inflammation and susceptibility to bacterial infections in mice lacking the polypeptide (p)105 precursor (NF-kappaB1) but expressing p50.

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7 January 2021

High susceptibility to bacterial infection, but no liver dysfunction, in mice compromised for hepatocyte NF-kappaB activation

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7 January 2021

Incontinentia pigmenti in a surviving male is accompanied by hypohidrotic ectodermal dysplasia and recurrent infection

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7 January 2021

Perturbation of the T lymphocyte lineage in transgenic mice expressing a constitutive repressor of nuclear factor (NF)-kappaB.

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7 January 2021

An essential role for nuclear factor kappaB in promoting double positive thymocyte apoptosis

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7 January 2021

The anti-apoptotic activities of Rel and RelA required during B-cell maturation involve the regulation of Bcl-2 expression

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7 January 2021

NF-kappa B activation by the pre-T cell receptor serves as a selective survival signal in T lymphocyte development

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7 January 2021

Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity

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7 January 2021

Identification of the receptor component of the IkappaBalpha-ubiquitin ligase

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7 January 2021

The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro

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7 January 2021

Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP

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7 January 2021

Molecular dissection of the interactions among IkappaBalpha, FWD1, and Skp1 required for ubiquitin-mediated proteolysis of IkappaBalpha

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7 January 2021

Inducible degradation of IkappaBalpha by the proteasome requires interaction with the F-box protein h-betaTrCP.

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7 January 2021

Inhibition of NF-kappa-B cellular function via specific targeting of the I-kappa-B-ubiquitin ligase

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7 January 2021

A nuclear export signal in the N-terminal regulatory domain of IkappaBalpha controls cytoplasmic localization of inactive NF-kappaB/IkappaBalpha complexes

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7 January 2021

An N-terminal nuclear export signal is required for the nucleocytoplasmic shuttling of IkappaBalpha

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7 January 2021

IkappaBbeta, but not IkappaBalpha, functions as a classical cytoplasmic inhibitor of NF-kappaB dimers by masking both NF-kappaB nuclear localization sequences in resting cells

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7 January 2021

IkappaB family members function by different mechanisms

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7 January 2021

Ubiquitination and deubiquitination: targeting of proteins for degradation by the proteasome

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7 January 2021

Prokaryotic regulation of epithelial responses by inhibition of IkappaB-alpha ubiquitination

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7 January 2021

Cotranslational biogenesis of NF-kappaB p50 by the 26S proteasome

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7 January 2021

Mechanisms of ubiquitin-mediated, limited processing of the NF-kappaB1 precursor protein p105.

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7 January 2021

SCF(beta)(-TrCP) ubiquitin ligase-mediated processing of NF-kappaB p105 requires phosphorylation of its C-terminus by IkappaB kinase

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7 January 2021

Shared pathways of IkappaB kinase-induced SCF(betaTrCP)-mediated ubiquitination and degradation for the NF-kappaB precursor p105 and IkappaBalpha

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7 January 2021

Structural motifs involved in ubiquitin-mediated processing of the NF-kappaB precursor p105: roles of the glycine-rich region and a downstream ubiquitination domain

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7 January 2021

Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway

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7 January 2021

A glycine-rich region in NF-kappaB p105 functions as a processing signal for the generation of the p50 subunit

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7 January 2021

Inhibition of ubiquitin/proteasome-dependent protein degradation by the Gly-Ala repeat domain of the Epstein-Barr virus nuclear antigen 1.

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7 January 2021

Activation of a membrane-bound transcription factor by regulated ubiquitin/proteasome-dependent processing.

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7 January 2021

NF-κB p105 Processing via the Ubiquitin-Proteasome Pathway

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7 January 2021

A Drosophila IkappaB kinase complex required for Relish cleavage and antibacterial immunity

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7 January 2021

Activation of the Drosophila NF-kappaB factor Relish by rapid endoproteolytic cleavage

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7 January 2021

The Drosophila caspase Dredd is required to resist gram-negative bacterial infection

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7 January 2021

The IL-1 receptor/toll-like receptor superfamily: crucial receptors for inflammation and host defense

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7 January 2021

Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain

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7 January 2021

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

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7 January 2021

Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair

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7 January 2021

T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-γ

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7 January 2021

XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway

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7 January 2021

Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli

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7 January 2021

Site-specific phosphorylation of IkappaBalpha by a novel ubiquitination-dependent protein kinase activity

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7 January 2021

A new ticket for entry into budding vesicles-ubiquitin

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7 January 2021

Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-I.

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7 January 2021

Involvement of the ubiquitin/proteasome system in sorting of the interleukin 2 receptor beta chain to late endocytic compartments

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7 January 2021

Cbl: many adaptations to regulate protein tyrosine kinases

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7 January 2021

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7 January 2021

The product of the proto-oncogene c-cbl: a negative regulator of the Syk tyrosine kinase

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7 January 2021

Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1

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7 January 2021

The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase

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7 January 2021

The Cbl protooncoprotein stimulates CSF-1 receptor multiubiquitination and endocytosis, and attenuates macrophage proliferation

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7 January 2021

Proteolysis-independent regulation of PI3K by Cbl-b-mediated ubiquitination in T cells.

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7 January 2021

Lymphocyte signaling: Cbl sets the threshold for autoimmunity

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7 January 2021

Cbl-b regulates the CD28 dependence of T-cell activation.

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7 January 2021

Cbl-b is a negative regulator of receptor clustering and raft aggregation in T cells

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7 January 2021

Molecular controls of antigen receptor clustering and autoimmunity

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7 January 2021

Cbl-b, a RING-type E3 ubiquitin ligase, targets phosphatidylinositol 3-kinase for ubiquitination in T cells.

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7 January 2021

Deubiquitinating enzymes: a new class of biological regulators

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7 January 2021

The deubiquitinating enzyme DUB-2 prolongs cytokine-induced signal transducers and activators of transcription activation and suppresses apoptosis following cytokine withdrawal

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7 January 2021

Negative regulation of cytokine signaling pathways

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7 January 2021

JAB/SOCS1/SSI-1 is an interleukin-2-induced inhibitor of IL-2 signaling

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7 January 2021

SOCS proteins: negative regulators of cytokine signaling

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7 January 2021

Suppressor of cytokine signaling-1 inhibits VAV function through protein degradation.

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7 January 2021

Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication

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7 January 2021