(Q28212042)

1

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Yvonne S Lin

2

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Erin G Schuetz

3

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Kenneth E Thummel

Advanced Drug Delivery Reviews

4

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language of work or name

English

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publication date

18 November 2002

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published in

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volume

54

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issue

10

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page(s)

1271-94

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cites work

Cytochrome P-450 3A4: regulation and role in drug metabolism

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7 January 2021

Evaluation of Atypical Cytochrome P450 Kinetics with Two-Substrate Models: Evidence That Multiple Substrates Can Simultaneously Bind to Cytochrome P450 Active Sites

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7 January 2021

Enzyme-catalyzed processes of first-pass hepatic and intestinal drug extraction

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7 January 2021

Role of Cytochrome P450 Enzymes in Drug-Drug Interactions

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7 January 2021

In vitro and in vivo drug interactions involving human CYP3A

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7 January 2021

Cytochrome P450 3A expression in the human fetal liver: evidence that CYP3A5 is expressed in only a limited number of fetal livers

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7 January 2021

Cytochrome P450 3A: ontogeny and drug disposition

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https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

No ethnic difference between Caucasian and Japanese hepatic samples in the expression frequency of CYP3A5 and CYP3A7 proteins

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https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

cDNA cloning and initial characterization of CYP3A43, a novel human cytochrome P450

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7 January 2021

Cloning and tissue distribution of a novel human cytochrome p450 of the CYP3A subfamily, CYP3A43.

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https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

Evaluation of the genetic component of variability in CYP3A4 activity: a repeated drug administration method

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https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

Detection of CYP3A5 allelic variant: a candidate for the polymorphic expression of the protein?

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https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression

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https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

The genetic determinants of the CYP3A5 polymorphism

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https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

Co-regulation of CYP3A4 and CYP3A5 and contribution to hepatic and intestinal midazolam metabolism

1 reference

https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

Regioselective biotransformation of midazolam by members of the human cytochrome P450 3A (CYP3A) subfamily

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https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

Lidocaine metabolism in human liver microsomes by cytochrome P450IIIA4.

1 reference

https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

Possible involvement of multiple cytochrome P450S in fentanyl and sufentanil metabolism as opposed to alfentanil

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https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

Steroid hormone hydroxylase specificities of eleven cDNA-expressed human cytochrome P450s

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https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

Comparative metabolic capabilities of CYP3A4, CYP3A5, and CYP3A7.

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https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

Expression of Cytochrome-P450-3A5 in Escherichia Coli: Effects of 5′ Modification, Purification, Spectral Characterization, Reconstitution Conditions, and Catalytic Activities

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https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

The high-level expression in Escherichia coli of the membrane-bound form of human and rat cytochrome b5 and studies on their mechanism of function

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https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

Roles of divalent metal ions in oxidations catalyzed by recombinant cytochrome P450 3A4 and replacement of NADPH--cytochrome P450 reductase with other flavoproteins, ferredoxin, and oxygen surrogates.

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https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

Effects of human cytochrome b5 on CYP3A4 activity and stability in vivo

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https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

In vitro/in vivo scaling of alprazolam metabolism by CYP3A4 and CYP3A5 in humans

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https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

Selective expression of cytochrome P450 CYP3A mRNAs in embryonic and adult human liver

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https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

Perinatal expression and inducibility of human CYP3A7 in C57BL/6N transgenic mice

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https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

Four forms of cytochrome P-450 in human fetal liver: purification and their capacity to activate promutagens.

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https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

Noninvasive tests of CYP3A enzymes

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https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

The erythromycin breath test predicts the clearance of midazolam

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https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

Absence of correlations among three putative in vivo probes of human cytochrome P4503A activity in young healthy men

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https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

Mdr1 limits CYP3A metabolism in vivo.

1 reference

https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

CYP3A4 drug interactions: correlation of 10 in vitro probe substrates

1 reference

https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

In-vivo phenotyping for CYP3A by a single-point determination of midazolam plasma concentration

1 reference

https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

Lack of bimodality in nifedipine plasma kinetics in a large population of healthy subjects

1 reference

https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

Interpatient variability in bioavailability is related to the extent of absorption: implications for bioavailability and bioequivalence studies

1 reference

https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

Population pharmacokinetics of terfenadine

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https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

Clinical pharmacokinetics of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors

1 reference

https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

Metabolism and disposition of buspirone

1 reference

https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

Comparative pharmacokinetics of alprazolam and lorazepam in humans and in African Green Monkeys

1 reference

https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

Clinical pharmacokinetics and pharmacodynamics of zolpidem. Therapeutic implications

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https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

Pharmacogenomics: translating functional genomics into rational therapeutics

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https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

Receptor-dependent transcriptional activation of cytochrome P4503A genes: induction mechanisms, species differences and interindividual variation in man.

1 reference

https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

Regulation of cyp3a gene transcription by the pregnane x receptor

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https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

Transcriptional control of intestinal cytochrome P-4503A by 1alpha,25-dihydroxy vitamin D3.

1 reference

https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

Separate and Interactive Regulation of Cytochrome P450 3A4 by Triiodothyronine, Dexamethasone, and Growth Hormone in Cultured Hepatocytes1

1 reference

https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

Human P450PCN1: sequence, chromosome localization, and direct evidence through cDNA expression that P450PCN1 is nifedipine oxidase

1 reference

https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

Modification of clinical presentation of prostate tumors by a novel genetic variant in CYP3A4.

1 reference

https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

Population distribution and effects on drug metabolism of a genetic variant in the 5' promoter region of CYP3A4

1 reference

https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

CYP3A4 variant alleles in white individuals with low CYP3A4 enzyme activity

1 reference

https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

CYP3A4 allelic variants with amino acid substitutions in exons 7 and 12: evidence for an allelic variant with altered catalytic activity

1 reference

https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

Common allelic variants of cytochrome P4503A4 and their prevalence in different populations

1 reference

https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

Mutation analysis of the human CYP3A4 gene 5' regulatory region: population screening using non-radioactive SSCP

1 reference

https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

Identification and functional characterization of eight CYP3A4 protein variants

1 reference

https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

RESPONSE: re: modification of clinical presentation of prostate tumors by a novel genetic variant in CYP3A4

1 reference

https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

Re: Modification of clinical presentation of prostate tumors by a novel genetic variant in CYP3A4

1 reference

https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

Interindividual differences in hepatic expression of CYP3A4: relationship to genetic polymorphism in the 5'-upstream regulatory region

1 reference

https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

CYP3A activity in African American and European American men: population differences and functional effect of the CYP3A4*1B5'-promoter region polymorphism

1 reference

https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

Association of CYP3A4 genotype with treatment-related leukemia

1 reference

https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

CYP gene polymorphisms and early menarche

1 reference

https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

Characterization of a cDNA encoding a new member of the glucocorticoid-responsive cytochromes P450 in human liver

1 reference

https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

Sequence of the 5'-flanking region of CYP3A5: comparative analysis with CYP3A4 and CYP3A7

1 reference

https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

The human cytochrome P450 3A locus. Gene evolution by capture of downstream exons

1 reference

https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

Two linked mutations in transcriptional regulatory elements of the CYP3A5 gene constitute the major genetic determinant of polymorphic activity in humans

1 reference

https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

Cooperativity in oxidations catalyzed by cytochrome P450 3A4.

1 reference

https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

Expression of cytochrome P450 3A in amphibian, rat, and human kidney

1 reference

https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

Expression of cytochrome P 450 3A enzymes in human lung: a combined RT-PCR and immunohistochemical analysis of normal tissue and lung tumours.

1 reference

https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

Human prostate CYP3A5: identification of a unique 5'-untranslated sequence and characterization of purified recombinant protein

1 reference

https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

Selective expression of CYP3A5 and not CYP3A4 in human blood

1 reference

https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

Corticosterone 6 beta-hydroxylase in A6 epithelia: a steroid-inducible cytochrome P-450.

1 reference

https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

NADPH-dependent metabolism of estrone by human liver microsomes

1 reference

https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

16Alpha-hydroxylation of estrone by human cytochrome P4503A4/5

1 reference

https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

Molecular cloning and sequence analysis of cDNA containing the entire coding region for human fetal liver cytochrome P-450

1 reference

https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

Fetal hepatic drug elimination

1 reference

https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

Identification of the fetal liver cytochrome CYP3A7 in human endometrium and placenta

1 reference

https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

Intergenic mRNA molecules resulting from trans-splicing

1 reference

https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

The human pregnane X receptor: genomic structure and identification and functional characterization of natural allelic variants

1 reference

https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

Vitamin D-receptor genotypes as independent genetic predictors of decreased bone mineral density in primary biliary cirrhosis

1 reference

https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

Functionally relevant polymorphisms in the human nuclear vitamin D receptor gene

1 reference

https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021

Molecular nature of the vitamin D receptor and its role in regulation of gene expression

1 reference

https://api.crossref.org/works/10.1016/S0169-409X(02)50066-2

7 January 2021