(Q28115758)

3 January 2017

title

Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy (English)

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3 January 2017

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20

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Adrian Pasculescu

2

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Anthony Pawson

19

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Jonathan So

object named as

Jonathan So

1

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Jeffrey L. Wrana

16

object named as

Jeffrey L. Wrana

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3 January 2017

17

Rune Linding

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3 January 2017

Anna Y. Dai

3

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3 January 2017

Kelly Williton

4

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3 January 2017

Andrew James

5

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3 January 2017

Vivian Nguyen

6

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3 January 2017

Pau Creixell

7

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3 January 2017

Erwin M. Schoof

8

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3 January 2017

John Sinclair

9

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3 January 2017

Miriam Barrios-Rodiles

10

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3 January 2017

Jun Gu

11

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3 January 2017

Aldis Krizus

12

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3 January 2017

Ryan Williams

13

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3 January 2017

Marina Olhovsky

14

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3 January 2017

James W. Dennis

15

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3 January 2017

Claus Jorgensen

18

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3 January 2017

publication date

7 April 2015

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3 January 2017

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3 January 2017

volume

8

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3 January 2017

issue

371

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3 January 2017

page(s)

rs3

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Mechanisms of caspase activation

3 January 2017

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21 April 2017

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Targeted disruption of the zetaPKC gene results in the impairment of the NF-kappaB pathway

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Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling

21 April 2017

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Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family

21 April 2017

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Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor

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A probability-based approach for high-throughput protein phosphorylation analysis and site localization

21 April 2017

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Cell-specific information processing in segregating populations of Eph receptor ephrin-expressing cells

21 April 2017

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The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored

21 April 2017

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A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes

21 April 2017

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Abnormal photoresponses and light-induced apoptosis in rods lacking rhodopsin kinase

21 April 2017

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Augmentation of therapeutic responses in melanoma by inhibition of IRAK-1,-4

21 April 2017

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Involvement of maternal embryonic leucine zipper kinase (MELK) in mammary carcinogenesis through interaction with Bcl-G, a pro-apoptotic member of the Bcl-2 family

21 April 2017

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https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

RICK, a novel protein kinase containing a caspase recruitment domain, interacts with CLARP and regulates CD95-mediated apoptosis

21 April 2017

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https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

Raf-1 sets the threshold of Fas sensitivity by modulating Rok-alpha signaling

21 April 2017

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https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

ROCK-II-induced membrane blebbing and chromatin condensation require actin cytoskeleton

21 April 2017

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https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

Interactive Tree Of Life (iTOL): an online tool for phylogenetic tree display and annotation

21 April 2017

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https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

21 April 2017

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https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

PhosphoSite: A bioinformatics resource dedicated to physiological protein phosphorylation

21 April 2017

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https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function

21 April 2017

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https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

New insights into apoptosis signaling by Apo2L/TRAIL.

21 April 2017

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https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

TRAIL on trial: preclinical advances in cancer therapy

21 January 2018

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https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

Accumulation of driver and passenger mutations during tumor progression

21 January 2018

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https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

Getting TRAIL back on track for cancer therapy

21 January 2018

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https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

Exploring death receptor pathways as selective targets in cancer therapy

21 January 2018

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https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

On the TRAIL to successful cancer therapy? Predicting and counteracting resistance against TRAIL-based therapeutics

21 January 2018

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https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

TRAIL receptor signaling and therapeutics.

21 January 2018

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https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

Directing cancer cells to self-destruct with pro-apoptotic receptor agonists

21 January 2018

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https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

The regulatory crosstalk between kinases and proteases in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

Non-canonical kinase signaling by the death ligand TRAIL in cancer cells: discord in the death receptor family

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

Inhibition of TRAIL-induced apoptosis by Bcl-2 overexpression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

Src and ADAM-17-mediated shedding of transforming growth factor-alpha is a mechanism of acute resistance to TRAIL

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

Mutation, specialization, and hypersensitivity in highly optimized tolerance

21 January 2018

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A test of highly optimized tolerance reveals fragile cell-cycle mechanisms are molecular targets in clinical cancer trials

21 January 2018

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A robustness-based approach to systems-oriented drug design

21 January 2018

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21 January 2018

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Dynamic modularity in protein interaction networks predicts breast cancer outcome

21 January 2018

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https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

Molecular signaling network complexity is correlated with cancer patient survivability

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

The importance of bottlenecks in protein networks: correlation with gene essentiality and expression dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

Network analyses in systems pharmacology

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

Quantitative analysis of pathways controlling extrinsic apoptosis in single cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

High-contrast imaging of fluorescent protein FRET by fluorescence polarization microscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

Imaging molecular interactions in cells by dynamic and static fluorescence anisotropy (rFLIM and emFRET).

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

A peptide-based target screen implicates the protein kinase CK2 in the global regulation of caspase signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

The protein interaction landscape of the human CMGC kinase group

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

RioK1, a new interactor of protein arginine methyltransferase 5 (PRMT5), competes with pICln for binding and modulates PRMT5 complex composition and substrate specificity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

Fibronectin-stimulated signaling from a focal adhesion kinase-c-Src complex: involvement of the Grb2, p130cas, and Nck adaptor proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

Introduction of p130cas signaling complex formation upon integrin-mediated cell adhesion: a role for Src family kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

The COP9 signalosome: more than a protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

Characterization of PXK as a protein involved in epidermal growth factor receptor trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

Linear Motif Atlas for Phosphorylation-Dependent Signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

Systematic Discovery of In Vivo Phosphorylation Networks

21 January 2018

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https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

NetworKIN: a resource for exploring cellular phosphorylation networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

Regulation of multisite phosphorylation and 14-3-3 binding of AS160 in response to IGF-1, EGF, PMA and AICAR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

Glucose transport and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

Rac1 activation controls nuclear localization of beta-catenin during canonical Wnt signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

Tumor necrosis factor-induced microtubule stabilization mediated by hyperphosphorylated oncoprotein 18 promotes cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

Transformation by oncogenic RAS sensitizes human colon cells to TRAIL-induced apoptosis by up-regulating death receptor 4 and death receptor 5 through a MEK-dependent pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

Genome-scale microRNA and small interfering RNA screens identify small RNA modulators of TRAIL-induced apoptosis pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

Identification of Modulators of TRAIL-Induced Apoptosis via RNAi-Based Phenotypic Screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

A synthetic lethal screen identifies FAT1 as an antagonist of caspase-8 in extrinsic apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

Activation of DNA-dependent protein kinase may play a role in apoptosis of human neuroblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

Inactivation of DNA-dependent protein kinase by protein kinase Cdelta: implications for apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

The catalytic subunit of DNA-dependent protein kinase selectively regulates p53-dependent apoptosis but not cell-cycle arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

ATM and the catalytic subunit of DNA-dependent protein kinase activate NF-kappaB through a common MEK/extracellular signal-regulated kinase/p90(rsk) signaling pathway in response to distinct forms of DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

MAPK/ERK overrides the apoptotic signaling from Fas, TNF, and TRAIL receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

JNK1 determines the oncogenic or tumor-suppressive activity of the integrin-linked kinase in human rhabdomyosarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

A systems model of signaling identifies a molecular basis set for cytokine-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

IRAK-4--a shared NF-kappaB activator in innate and acquired immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

Caspase-mediated cleavage of beta-catenin precedes drug-induced apoptosis in resistant cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

Death-receptor activation halts clathrin-dependent endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

Receptor-mediated endocytosis is not required for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

c-Cbl-mediated degradation of TRAIL receptors is responsible for the development of the early phase of TRAIL resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

Breakdown of endocytosis in the oncogenic activation of receptor tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

Deficient tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor transport to the cell surface in human colon cancer cells selected for resistance to TRAIL-induced apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

Network-based global inference of human disease genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

Predicting disease genes using protein-protein interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

Identification and characterization of human Wee1B, a new member of the Wee1 family of Cdk-inhibitory kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

IRAK1: a critical signaling mediator of innate immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

Cell polarity: Par6, aPKC and cytoskeletal crosstalk

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

Evaluating DAPK as a therapeutic target.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

Activation of protein kinase C inhibits TRAIL-induced caspases activation, mitochondrial events and apoptosis in a human leukemic T cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

Persistent inhibition of ABL tyrosine kinase causes enhanced apoptotic response to TRAIL and disrupts the pro-apoptotic effect of chloroquine

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

Building a human kinase gene repository: bioinformatics, molecular cloning, and functional validation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

Validating Aurora B as an anti-cancer drug target.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

CoreFlow: a computational platform for integration, analysis and modeling of complex biological data

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

ProHits: integrated software for mass spectrometry-based interaction proteomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

A multidimensional chromatography technology for in-depth phosphoproteome analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

SIMAC (sequential elution from IMAC), a phosphoproteomics strategy for the rapid separation of monophosphorylated from multiply phosphorylated peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

Inhibiting EGF receptor or SRC family kinase signaling overcomes BRAF inhibitor resistance in melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

Death receptor 5 internalization is required for lysosomal permeabilization by TRAIL in malignant liver cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

Gene expression profiles of light-induced apoptosis in arrestin/rhodopsin kinase-deficient mouse retinas

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

Evidence for two apoptotic pathways in light-induced retinal degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

Blocking caspase-3-mediated proteolysis of IKKbeta suppresses TNF-alpha-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

Severe liver degeneration in mice lacking the IkappaB kinase 2 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

The integrin-linked kinase (ILK) suppresses anoikis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

A kinome-wide siRNA screen identifies multiple roles for protein kinases in hypoxic stress adaptation, including roles for IRAK4 and GAK in protection against apoptosis in VHL-/- renal carcinoma cells, despite activation of the NF-κB pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

Cell death triggered by Yersinia enterocolitica identifies processing of the proinflammatory signal adapter MyD88 as a general event in the execution of apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

Rho kinase in the regulation of cell death and survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

Thirty-eight-negative kinase 1 (TNK1) facilitates TNFα-induced apoptosis by blocking NF-κB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

High-throughput RNAi Screening Identifies a Role for TNK1 in Growth and Survival of Pancreatic Cancer Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2005700

10.1126/SCISIGNAL.2005700

21 January 2018

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