(Q27690748)

Lessons from mathematically modeling the NF‐κB pathway (English)

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2011.01092.X

27 December 2024

0 references

1 reference

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modelling biological systems

27 December 2024

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27 December 2024

1

Soumen Basak

1 reference

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27 December 2024

author name string

Marcelo Behar

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:22435558

27 December 2024

Alexander Hoffmann

series ordinal

3

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27 December 2024

language of work or name

English

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National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=22435558

27 December 2024

publication date

March 2012

1 reference

full work available at URL

https://europepmc.org/articles/pmc3343698?pdf=render

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https://europepmc.org/articles/PMC3343698

27 December 2024

file format

HyperText Markup Language

online access status

open access

content deliverer

1 reference

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https://europepmc.org/articles/PMC3343698?pdf=render

27 December 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:22435558

https://doi.org/10.1111/j.1600-065x.2011.01092.x

27 December 2024

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:22435558

https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111/j.1600-065X.2011.01092.x

27 December 2024

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2011.01092.X

https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1600-065X.2011.01092.x

27 December 2024

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2011.01092.X

27 December 2024

published in

Immunological Reviews

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volume

246

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issue

1

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page(s)

221-38

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Sustained oscillations of NF-kappaB produce distinct genome scanning and gene expression profiles

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343698

Generation and activation of multiple dimeric transcription factors within the NF-kappaB signaling system

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343698

A fourth IkappaB protein within the NF-kappaB signaling module

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343698

Hodgkin lymphoma cells express TACI and BCMA receptors and generate survival and proliferation signals in response to BAFF and APRIL

20 March 2017

1 reference

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Role of unphosphorylated, newly synthesized I kappa B beta in persistent activation of NF-kappa B

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343698

Oncogenically active MYD88 mutations in human lymphoma

20 March 2017

1 reference

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Oscillations in NF-kappaB signaling control the dynamics of gene expression

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343698

Drug Inhibition Profile Prediction for NFκB Pathway in Multiple Myeloma

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343698

Information transduction capacity of noisy biochemical signaling networks

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343698

NF-kappaB dictates the degradation pathway of IkappaBalpha

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343698

The protective effect of A20 on atherosclerosis in apolipoprotein E-deficient mice is associated with reduced expression of NF-kappaB target genes

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343698

The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343698

A new approach to decoding life: systems biology

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343698

Regulation of cell death and autophagy by IKK and NF‐κB: critical mechanisms in immune function and cancer

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343698

The noncanonical NF‐κB pathway

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343698

Malignant pirates of the immune system

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343698

Sources of cell-to-cell variability in canonical nuclear factor-κB (NF-κB) signaling pathway inferred from single cell dynamic images.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343698

Modeling the NF-κB mediated inflammatory response predicts cytokine waves in tissue

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343698

Sensitivity analysis of dynamic biological systems with time-delays

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343698

Understanding the temporal codes of intra-cellular signals

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343698

Oscillatory control of signalling molecules

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343698

IkappaBbeta acts to inhibit and activate gene expression during the inflammatory response

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343698

Flexible Regions within IκBα Create the Ubiquitin-independent Degradation Signal

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343698

Computational modeling with forward and reverse engineering links signaling network and genomic regulatory responses: NF-kappaB signaling-induced gene expression responses in inflammation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343698

Noncooperative interactions between transcription factors and clustered DNA binding sites enable graded transcriptional responses to environmental inputs

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343698

The Nfkb1 and Nfkb2 proteins p105 and p100 function as the core of high-molecular-weight heterogeneous complexes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343698

Kinetic control of negative feedback regulators of NF-kappaB/RelA determines their pathogen- and cytokine-receptor signaling specificity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343698

Frequent inactivation of A20 in B-cell lymphomas

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343698

Pulsatile stimulation determines timing and specificity of NF-kappaB-dependent transcription

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343698

Tonic B cell antigen receptor signals supply an NF-kappaB substrate for prosurvival BLyS signaling.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343698

Integrating computational and biochemical studies to explore mechanisms in NF-{kappa}B signaling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343698

New regulators of NF-kappaB in inflammation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343698

Robust simplifications of multiscale biochemical networks

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343698

Dynamic effect of bortezomib on nuclear factor-kappaB activity and gene expression in tumor cells.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343698

Encoding NF-kappaB temporal control in response to TNF: distinct roles for the negative regulators IkappaBalpha and A20.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343698

Crosstalk via the NF-kappaB signaling system

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343698

Pre-folding IkappaBalpha alters control of NF-kappaB signaling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343698

Understanding NF-kappaB signaling via mathematical modeling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343698

Single TNFalpha trimers mediating NF-kappaB activation: stochastic robustness of NF-kappaB signaling.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343698

Minimal model of spiky oscillations in NF-kappaB signaling.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343698

IkappaBepsilon provides negative feedback to control NF-kappaB oscillations, signaling dynamics, and inflammatory gene expression.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343698

Circuitry of nuclear factor kappaB signaling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343698

Transient IkappaB kinase activity mediates temporal NF-kappaB dynamics in response to a wide range of tumor necrosis factor-alpha doses

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343698

Stochastic regulation in early immune response

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343698

Stimulus specificity of gene expression programs determined by temporal control of IKK activity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343698

Achieving stability of lipopolysaccharide-induced NF-kappaB activation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343698

Comment on "Oscillations in NF-kappaB signaling control the dynamics of gene expression".

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343698

Investigations into the analysis and modeling of the TNF alpha-mediated NF-kappa B-signaling pathway

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343698

Signal-dependent and -independent degradation of free and NF-kappa B-bound IkappaBalpha

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343698

Clonal deleterious mutations in the IkappaBalpha gene in the malignant cells in Hodgkin's lymphoma

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343698

A noisy paracrine signal determines the cellular NF-kappaB response to lipopolysaccharide

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343698

UV as an amplifier rather than inducer of NF-kappaB activity

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343698

A homeostatic model of IkappaB metabolism to control constitutive NF-kappaB activity

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343698

Defective Peyer's patch organogenesis in mice lacking the 55-kD receptor for tumor necrosis factor

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343698

Mathematical model of NF-kappaB regulatory module

2 June 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2011.01092.X

NF-kappaB oscillations and cell-to-cell variability

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2011.01092.X

Mathematical modeling and sensitivity analysis of the integrated TNFα-mediated apoptotic pathway for identifying key regulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2011.01092.X

Mathematical modeling identified c-FLIP as an apoptotic switch in death receptor induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2011.01092.X

Oscillatory expression of Hes1, p53, and NF-kappaB driven by transcriptional time delays

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2011.01092.X

A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2011.01092.X

The lymphotoxin beta receptor controls organogenesis and affinity maturation in peripheral lymphoid tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2011.01092.X

Lymph node genesis is induced by signaling through the lymphotoxin beta receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2011.01092.X

IKKα limits macrophage NF-κB activation and contributes to the resolution of inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2011.01092.X

Dynamic shuttling of nuclear factor kappa B between the nucleus and cytoplasm as a consequence of inhibitor dissociation

21 January 2018

1 reference

12 December 2020

Regulation of p100 (NFKB2) expression in human monocytes in response to inflammatory mediators and lymphokines

1 reference

12 December 2020

Negative regulation of TCR signaling by NF-kappaB2/p100

1 reference

12 December 2020

Deterministic and stochastic models of NFkappaB pathway

1 reference

12 December 2020

Liber Abaci

series ordinal

1

author name string

Fibonacci L

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2011.01092.X

27 December 2024

Identifiers

1 reference

1 reference

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