(Q27677137)

Structural basis for the activation of innate immune pattern-recognition receptor RIG-I by viral RNA

GOA release 2020-03-11

Yorgo Modis

2

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author name string

Ian C Berke

series ordinal

1

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language of work or name

English

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publication date

4 April 2012

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published in

The EMBO Journal

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volume

31

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issue

7

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page(s)

1714-26

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cites work

1 reference

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Structural basis of RNA recognition and activation by innate immune receptor RIG-I

20 March 2017

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Structural and functional insights into 5′-ppp RNA pattern recognition by the innate immune receptor RIG-I

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LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses

20 March 2017

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20 March 2017

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Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus

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Regulation of signal transduction by enzymatically inactive antiviral RNA helicase proteins MDA5, RIG-I, and LGP2

20 March 2017

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Agonist and Antagonist Recognition by RIG-I, a Cytoplasmic Innate Immunity Receptor

20 March 2017

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Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5

20 March 2017

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20 March 2017

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The C-terminal regulatory domain is the RNA 5'-triphosphate sensor of RIG-I

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Nonself RNA-sensing mechanism of RIG-I helicase and activation of antiviral immune responses

20 March 2017

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Death Domain Assembly Mechanism Revealed by Crystal Structure of the Oligomeric PIDDosome Core Complex

20 March 2017

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Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2

20 March 2017

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Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus

20 March 2017

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IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

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A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M

20 March 2017

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20 March 2017

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mda-5: An interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties

20 March 2017

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RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphates

20 March 2017

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20 March 2017

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Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3

20 March 2017

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Refinement of macromolecular structures by the maximum-likelihood method

20 March 2017

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The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

20 March 2017

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A malaria parasite formin regulates actin polymerization and localizes to the parasite-erythrocyte moving junction during invasion

20 March 2017

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5'-Triphosphate RNA is the ligand for RIG-I

20 March 2017

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20 March 2017

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Divergent Effects of Human Cytomegalovirus and Herpes Simplex Virus-1 on Cellular Metabolism

20 March 2017

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Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity

20 March 2017

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Cooperative assembly and dynamic disassembly of MDA5 filaments for viral dsRNA recognition

7 April 2017

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Molecular mechanism of signal perception and integration by the innate immune sensor retinoic acid-inducible gene-I (RIG-I).

29 September 2017

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RIG-I- and MDA5-initiated innate immunity linked with adaptive immunity accelerates beta-cell death in fulminant type 1 diabetes

29 September 2017

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The FANCM family of DNA helicases/translocases.

29 September 2017

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On the analysis of sedimentation velocity in the study of protein complexes

29 September 2017

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Mechanism of mda-5 Inhibition by paramyxovirus V proteins.

29 September 2017

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Translocation and unwinding mechanisms of RNA and DNA helicases

29 September 2017

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29 September 2017

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29 September 2017

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Innate immune responses in human monocyte-derived dendritic cells are highly dependent on the size and the 5' phosphorylation of RNA molecules

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21 January 2018

Identifiers

DOI

10.1038/EMBOJ.2012.19

1 reference

1 reference

1 reference

PubMed publication ID

22314235

1 reference