(Q27547991)

P-loop containing nucleoside triphosphate hydrolase

1 reference

RAD50, zinc hook, protein family

1 reference

based on heuristic

inferred from protein domain or family

Rad50/SbcC-type AAA domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Saccharomyces cerevisiae S288c

1 reference

25 May 2022

1 reference

25 May 2022

Superfamily of UvrA-related NTP-binding proteins. Implications for rational classification of recombination/repair systems

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12753

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12753

14 February 2019

14 February 2019

Effect of amino acid substitutions in the rad50 ATP binding domain on DNA double strand break repair in yeast

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12753

metal ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12753

1 reference

9 May 2019

single-stranded telomeric DNA binding

1 reference

5 June 2018

The characterization of Saccharomyces cerevisiae Mre11/Rad50/Xrs2 complex reveals that Rad50 negatively regulates Mre11 endonucleolytic but not the exonucleolytic activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12753&geneProductId=UniProtKB:P12753

telomeric DNA binding

1 reference

9 May 2019

Late S phase-specific recruitment of Mre11 complex triggers hierarchical assembly of telomere replication proteins in Saccharomyces cerevisiae.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12753

hydrolase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12753

1 reference

9 May 2019

double-stranded telomeric DNA binding

1 reference

5 June 2018

The characterization of Saccharomyces cerevisiae Mre11/Rad50/Xrs2 complex reveals that Rad50 negatively regulates Mre11 endonucleolytic but not the exonucleolytic activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12753&geneProductId=UniProtKB:P12753

double-stranded DNA binding

ATP binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12753

1 reference

9 May 2019

G-quadruplex DNA binding

1 reference

5 June 2018

The characterization of Saccharomyces cerevisiae Mre11/Rad50/Xrs2 complex reveals that Rad50 negatively regulates Mre11 endonucleolytic but not the exonucleolytic activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12753&geneProductId=UniProtKB:P12753

nucleotide binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12753

1 reference

9 May 2019

single-stranded DNA endodeoxyribonuclease activity

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12753

DNA helicase activity

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12753

protein binding

9 references

9 May 2019

Mechanism of the ATP-dependent DNA end-resection machinery from Saccharomyces cerevisiae.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12753

9 May 2019

Complex formation and functional versatility of Mre11 of budding yeast in recombination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12753

9 May 2019

Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12753

9 May 2019

Structure of Mre11–Nbs1 complex yields insights into ataxia-telangiectasia–like disease mutations and DNA damage signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12753

9 May 2019

Antiviral protein Ski8 is a direct partner of Spo11 in meiotic DNA break formation, independent of its cytoplasmic role in RNA metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12753

9 May 2019

Sae2 promotes dsDNA endonuclease activity within Mre11-Rad50-Xrs2 to resect DNA breaks

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12753

9 May 2019

Tel1 and Rif2 Regulate MRX Functions in End-Tethering and Repair of DNA Double-Strand Breaks

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12753

9 May 2019

DNA end recognition by the Mre11 nuclease dimer: insights into resection and repair of damaged DNA.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12753

9 May 2019

The Rad50 coiled-coil domain is indispensable for Mre11 complex functions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12753

3'-5' exonuclease activity

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12753

double-stranded telomeric DNA binding

adenylate kinase activity

Rad50 adenylate kinase activity regulates DNA tethering by Mre11/Rad50 complexes

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12753

9 May 2019

Rad50 adenylate kinase activity regulates DNA tethering by Mre11/Rad50 complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12753

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12753

single-stranded telomeric DNA binding

G-quadruplex DNA binding

double-stranded DNA binding

1 reference

9 May 2019

RAD50 protein of S.cerevisiae exhibits ATP-dependent DNA binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12753

condensed nuclear chromosome

cell component

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12753

nucleoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12753

1 reference

9 May 2019

site of double-strand break

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12753

Mre11 complex

Complex formation and functional versatility of Mre11 of budding yeast in recombination

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12753

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12753

9 May 2019

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12753

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12753

3 references

9 May 2019

9 May 2019

Complex formation and functional versatility of Mre11 of budding yeast in recombination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12753

9 May 2019

Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12753

HDA

mitochondrion

telomere maintenance via recombination

HDA

biological process

1 reference

5 June 2018

Two survivor pathways that allow growth in the absence of telomerase are generated by distinct telomere recombination events

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12753&geneProductId=UniProtKB:P12753

double-strand break repair via break-induced replication

1 reference

14 February 2019

Break-induced replication: a review and an example in budding yeast

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12753

meiotic DNA double-strand break formation

1 reference

14 February 2019

Meiotic chromosomes: it takes two to tango

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12753

meiotic DNA double-strand break processing

1 reference

14 February 2019

Meiotic chromosomes: it takes two to tango

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12753

negative regulation of endodeoxyribonuclease activity

1 reference

9 May 2019

The characterization of Saccharomyces cerevisiae Mre11/Rad50/Xrs2 complex reveals that Rad50 negatively regulates Mre11 endonucleolytic but not the exonucleolytic activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12753

mitochondrial double-strand break repair via homologous recombination

1 reference

9 May 2019

Mitochondrial genome maintenance: roles for nuclear nonhomologous end-joining proteins in Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12753

cellular response to DNA damage stimulus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12753

1 reference

9 May 2019

double-strand break repair via nonhomologous end joining

base-excision repair

1 reference

9 May 2019

A novel function for the Mre11-Rad50-Xrs2 complex in base excision repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12753

telomere maintenance via telomerase

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12753

reciprocal meiotic recombination

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12753&geneProductId=UniProtKB:P12753

1 reference

5 June 2018

telomere capping

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12753

DNA duplex unwinding

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12753

maintenance of DNA trinucleotide repeats

1 reference

9 May 2019

The Saccharomyces cerevisiae Mre11-Rad50-Xrs2 complex promotes trinucleotide repeat expansions independently of homologous recombination.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12753

nucleotide phosphorylation

1 reference

27 March 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12753&geneProductId=UniProtKB:P12753

chromosome organization involved in meiotic cell cycle

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12753

nucleoside monophosphate phosphorylation

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12753

telomere maintenance via recombination

nucleic acid phosphodiester bond hydrolysis

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12753

1 reference

Rad50/SbcC-type AAA domain

1 reference

Identifiers

1 reference

20 March 2022

1 reference

25 May 2022

1 reference