(Q24323081)

Transformation related protein 73

GOA release 2020-03-11

regulation of cell cycle

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POU domain, class 4, transcription factor 1

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author name string

C D Hudson

1

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A E Sayan

2

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G Melino

3

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R A Knight

4

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D S Latchman

5

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V Budhram-Mahadeo

Cell Death & Differentiation

6

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language of work or name

English

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publication date

August 2008

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published in

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volume

15

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issue

8

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page(s)

1266-78

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cites work

The virtuoso of versatility: POU proteins that flex to fit

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Requirement for Brn-3.0 in differentiation and survival of sensory and motor neurons

20 April 2017

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Targeted deletion of the mouse POU domain gene Brn-3a causes selective loss of neurons in the brainstem and trigeminal ganglion, uncoordinated limb movement, and impaired suckling

20 April 2017

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The BRN-3A transcription factor protects sensory but not sympathetic neurons from programmed cell death/apoptosis

20 April 2017

1 reference

p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities

20 April 2017

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p53 isoforms can regulate p53 transcriptional activity.

20 April 2017

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ASPP1 and ASPP2: common activators of p53 family members

20 April 2017

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p53 suppresses the activation of the Bcl-2 promoter by the Brn-3a POU family transcription factor

20 April 2017

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p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours

20 April 2017

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An anti-apoptotic role for the p53 family member, p73, during developmental neuron death

20 April 2017

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ASPP proteins specifically stimulate the apoptotic function of p53

20 April 2017

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Brn-3.0 expression identifies early post-mitotic CNS neurons and sensory neural precursors

20 April 2017

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Evidence that DeltaNp73 promotes neuronal survival by p53-dependent and p53-independent mechanisms

20 April 2017

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Physical interaction with Yes-associated protein enhances p73 transcriptional activity

20 April 2017

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Mouse Brn-3 family of POU transcription factors: a new aminoterminal domain is crucial for the oncogenic activity of Brn-3a

20 April 2017

1 reference

WAF1, a potential mediator of p53 tumor suppression

20 April 2017

1 reference

Monoallelically Expressed Gene Related to p53 at 1p36, a Region Frequently Deleted in Neuroblastoma and Other Human Cancers

20 April 2017

1 reference

The N-terminal domain unique to the long form of the Brn-3a transcription factor is essential to protect neuronal cells from apoptosis and for the activation of Bbcl-2 gene expression

20 April 2017

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The Brn-3a transcription factor

21 January 2018

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Distinct domains of Brn-3a regulate apoptosis and neurite outgrowth in vivo

21 January 2018

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On the shoulders of giants: p63, p73 and the rise of p53.

21 January 2018

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p73: Friend or foe in tumorigenesis

21 January 2018

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Two new p73 splice variants, gamma and delta, with different transcriptional activity.

21 January 2018

1 reference

Human delta Np73 regulates a dominant negative feedback loop for TAp73 and p53.

21 January 2018

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p53/p63/p73 isoforms: an orchestra of isoforms to harmonise cell differentiation and response to stress.

21 January 2018

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Brn-3a transcription factor blocks p53-mediated activation of proapoptotic target genes Noxa and Bax in vitro and in vivo to determine cell fate.

21 January 2018

1 reference

The Brn-3a transcription factor inhibits the pro-apoptotic effect of p53 and enhances cell cycle arrest by differentially regulating the activity of the p53 target genes encoding Bax and p21(CIP1/Waf1).

21 January 2018

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Induction of neuronal differentiation by p73 in a neuroblastoma cell line

21 January 2018

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Coexpression of Brn-3a POU protein with p53 in a population of neuronal progenitor cells is associated with differentiation and protection against apoptosis

21 January 2018

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p73: structure and function

21 January 2018

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New antibodies recognizing p73: comparison with commercial antibodies.

21 January 2018

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Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis

21 January 2018

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A novel form of Epstein-Barr virus latency in normal B cells in vivo

21 January 2018

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Yes-Associated Protein (YAP) is a critical mediator of c-Jun-dependent apoptosis

21 January 2018

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p63 and p73 are required for p53-dependent apoptosis in response to DNA damage

21 January 2018

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Brn-3a activates the expression of Bcl-x(L) and promotes neuronal survival in vivo as well as in vitro

21 January 2018

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7 January 2021

Defects in sensory axon growth precede neuronal death in Brn3a-deficient mice

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7 January 2021

New p73 variants with altered C-terminal structures have varied transcriptional activities

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7 January 2021

p73 is required for survival and maintenance of CNS neurons

1 reference

7 January 2021

The opposite and antagonistic effects of the closely related POU family transcription factors Brn-3a and Brn-3b on the activity of a target promoter are dependent on differences in the POU domain

1 reference

7 January 2021