(Q24315790)

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The zinc finger protein CTCF binds to the APBbeta domain of the amyloid beta-protein precursor promoter. Evidence for a role in transcriptional activation

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The zinc finger protein CTCF binds to the APBbeta domain of the amyloid beta-protein precursor promoter. Evidence for a role in transcriptional activation (English)

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CCCTC-binding factor

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GOA release 2020-03-11

positive regulation of transcription, DNA-templated

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GOA release 2020-03-11

author name string

A A Vostrov

1

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W W Quitschke

2

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language of work or name

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publication date

26 December 1997

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Journal of Biological Chemistry

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272

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52

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33353-9

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Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein

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The prevalence of amyloid (A4) protein deposits within the cerebral and cerebellar cortex in Down's syndrome and Alzheimer's disease

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Amyloid plaque core protein in Alzheimer disease and Down syndrome

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The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

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In situ hybridization of nucleus basalis neurons shows increased beta-amyloid mRNA in Alzheimer disease

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Relation of neuronal APP-751/APP-695 mRNA ratio and neuritic plaque density in Alzheimer's disease

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Expression of the Alzheimer amyloid precursor gene transcripts in the human brain.

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Structural features of the 5' upstream regulatory region of the gene encoding rat amyloid precursor protein

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Positive and negative regulatory elements for the expression of the Alzheimer's disease amyloid precursor-encoding gene in mouse

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Characterization of the 5'-end region and the first two exons of the beta-protein precursor gene

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Promoter activity of the gene encoding the beta-amyloid precursor protein is up-regulated by growth factors, phorbol ester, retinoic acid and interleukin-1.

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Repression of the beta-amyloid gene in a Hox-3.1-producing cell line

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Heat shock factor-1 mediates the transcriptional activation of Alzheimer's beta-amyloid precursor protein gene in response to stress

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Interleukin-1 stimulates the beta-amyloid precursor protein promoter

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Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells

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The rat amyloid precursor protein promoter contains two DNA regulatory elements which influence high level gene expression

1 reference

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The expression of the amyloid precursor protein (APP) is regulated by two GC-elements in the promoter

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DNA binding and regulatory effects of transcription factors SP1 and USF at the rat amyloid precursor protein gene promoter

1 reference

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Overlapping binding sites of two different transcription factors in the promoter of the human gene for the Alzheimer amyloid precursor protein.

1 reference

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The helix-loop-helix transcription factor USF interacts with the basal promoter of human amyloid precursor protein

1 reference

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USF binds to the APBα sequence in the promoter of the amyloid β-protein precursor gene

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Modular structure of a chicken lysozyme silencer: involvement of an unusual thyroid hormone receptor binding site

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Negative protein 1, which is required for function of the chicken lysozyme gene silencer in conjunction with hormone receptors, is identical to the multivalent zinc finger repressor CTCF.

1 reference

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CTCF, a conserved nuclear factor required for optimal transcriptional activity of the chicken c-myc gene, is an 11-Zn-finger protein differentially expressed in multiple forms

1 reference

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21 January 2018

An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes

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Temporal pattern of alcohol dehydrogenase gene transcription reproduced by Drosophila stage-specific embryonic extracts

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Purification and properties of Drosophila heat shock activator protein

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SV40 early-to-late switch involves titration of cellular transcriptional repressors

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Molecular weight abnormalities of the CTCF transcription factor: CTCF migrates aberrantly in SDS-PAGE and the size of the expressed protein is affected by the UTRs and sequences within the coding region of the CTCF gene

1 reference

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NeP1. A ubiquitous transcription factor synergizes with v-ERBA in transcriptional silencing

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Purification and stabilization of transcriptionally active glucocorticoid receptor

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Transcription factor binding and spacing constraints in the human β-actin proximal promoter

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Neurodegeneration in Alzheimer disease. Is apoptosis involved?

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Regulatory region of human amyloid precursor protein (APP) gene promotes neuron-specific gene expression in the CNS of transgenic mice.

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Enhanced gel mobility shift assay for DNA-binding factors

1 reference

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The initiator element and proximal upstream sequences affect transcriptional activity and start site selection in the amyloid beta-protein precursor promoter

1 reference

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inferred from DOI database lookup

The upstream stimulatory factor functionally interacts with the Alzheimer amyloid beta-protein precursor gene

1 reference

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DNA damage and apoptosis in Alzheimer's disease: colocalization with c-Jun immunoreactivity, relationship to brain area, and effect of postmortem delay.

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based on heuristic

inferred from DOI database lookup

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10.1074/JBC.272.52.33353

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