(Q24306167)

identical protein binding

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Elisa Greggio

6

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Alzbeta Trancikova

object named as

Alzbeta Trancikova

2

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Luigi Bubacco

object named as

Luigi Bubacco

5

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Liliane Glauser

4

object named as

Liliane Glauser

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author name string

Alice Biosa

1

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Laura Civiero

3

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Darren J Moore

Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study

7

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language of work or name

English

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publication date

15 March 2013

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published in

Human Molecular Genetics

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volume

22

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issue

6

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page(s)

1140-56

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cites work

1 reference

Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

21 January 2018

1 reference

Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

21 January 2018

1 reference

Mechanisms of LRRK2-Mediated Neurodegeneration

21 January 2018

1 reference

The Roco protein family: a functional perspective

21 January 2018

1 reference

GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease

21 January 2018

1 reference

The R1441C mutation of LRRK2 disrupts GTP hydrolysis

21 January 2018

1 reference

Kinase activity of mutant LRRK2 mediates neuronal toxicity

21 January 2018

1 reference

Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity

21 January 2018

1 reference

GTPase activity and neuronal toxicity of Parkinson's disease-associated LRRK2 is regulated by ArfGAP1

21 January 2018

1 reference

GTPase activity plays a key role in the pathobiology of LRRK2.

21 January 2018

1 reference

LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity

21 January 2018

1 reference

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

21 January 2018

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Kinase activity is required for the toxic effects of mutant LRRK2/dardarin

21 January 2018

1 reference

LRRK2 kinase activity is dependent on LRRK2 GTP binding capacity but independent of LRRK2 GTP binding

21 January 2018

1 reference

Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase

21 January 2018

1 reference

Membrane localization of LRRK2 is associated with increased formation of the highly active LRRK2 dimer and changes in its phosphorylation

21 January 2018

1 reference

The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation

21 January 2018

1 reference

Dependence of leucine-rich repeat kinase 2 (LRRK2) kinase activity on dimerization

21 January 2018

1 reference

The G2385R variant of leucine-rich repeat kinase 2 associated with Parkinson's disease is a partial loss-of-function mutation

21 January 2018

1 reference

The familial Parkinsonism gene LRRK2 regulates neurite process morphology

21 January 2018

1 reference

Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis

21 January 2018

1 reference

Chemoproteomics-based design of potent LRRK2-selective lead compounds that attenuate Parkinson's disease-related toxicity in human neurons

21 January 2018

1 reference

Phosphopeptide analysis reveals two discrete clusters of phosphorylation in the N-terminus and the Roc domain of the Parkinson-disease associated protein kinase LRRK2.

21 January 2018

1 reference

The Parkinson's disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites

21 January 2018

1 reference

Identification of the autophosphorylation sites of LRRK2.

21 January 2018

1 reference

Autophosphorylation in the leucine-rich repeat kinase 2 (LRRK2) GTPase domain modifies kinase and GTP-binding activities

21 January 2018

1 reference

Structure-Function Relationships of the G Domain, a Canonical Switch Motif

21 January 2018

1 reference

It takes two to tango: regulation of G proteins by dimerization

21 January 2018

1 reference

ArfGAP1 Is a GTPase Activating Protein for LRRK2: Reciprocal Regulation of ArfGAP1 by LRRK2

21 January 2018

1 reference

Re-examination of the dimerization state of leucine-rich repeat kinase 2: predominance of the monomeric form

21 January 2018

1 reference

Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells

21 January 2018

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LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice

21 January 2018

1 reference

A rat model of progressive nigral neurodegeneration induced by the Parkinson's disease-associated G2019S mutation in LRRK2.

21 January 2018

1 reference

Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration

21 January 2018

1 reference

The Parkinson disease gene LRRK2: evolutionary and structural insights

21 January 2018

1 reference