(Q22253478)

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Homeostatic modulation of cell surface KDR and Flt1 expression and expression of the vascular endothelial cell growth factor (VEGF) receptor mRNAs by VEGF

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Homeostatic modulation of cell surface KDR and Flt1 expression and expression of the vascular endothelial cell growth factor (VEGF) receptor mRNAs by VEGF (English)

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Fms related receptor tyrosine kinase 1

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GOA release 2020-03-11

positive regulation of cell population proliferation

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GOA release 2020-03-11

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based on heuristic

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author name string

D Wang

1

author given names

D

author last names

Wang

1 reference

PubMed publication ID

28 March 2023

D B Donner

2

author given names

D B

author last names

Donner

1 reference

PubMed publication ID

28 March 2023

R S Warren

3

author given names

R S

author last names

Warren

1 reference

PubMed publication ID

28 March 2023

language of work or name

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publication date

26 May 2000

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Journal of Biological Chemistry

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275

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21

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15905-11

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Mechanisms of angiogenesis

1 reference

https://api.crossref.org/works/10.1074/JBC.M001847200

21 January 2018

The biology of vascular endothelial growth factor

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https://api.crossref.org/works/10.1074/JBC.M001847200

21 January 2018

Vascular permeability factor: A unique regulator of blood vessel function

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https://api.crossref.org/works/10.1074/JBC.M001847200

21 January 2018

Molecular and biological properties of the vascular endothelial growth factor family of proteins

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Isolation and characterization of a vascular endothelial cell mitogen produced by pituitary-derived folliculo stellate cells

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Vascular endothelial growth factor is a secreted angiogenic mitogen

1 reference

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21 January 2018

Vascular permeability factor (vascular endothelial growth factor) gene is expressed differentially in normal tissues, macrophages, and tumors

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https://api.crossref.org/works/10.1074/JBC.M001847200

21 January 2018

Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis

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Patterns of expression of vascular endothelial growth factor (VEGF) and VEGF receptors in mice suggest a role in hormonally regulated angiogenesis

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21 January 2018

Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo.

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Regulation by vascular endothelial growth factor of human colon cancer tumorigenesis in a mouse model of experimental liver metastasis

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Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant

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The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor

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Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium

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A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit

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21 January 2018

Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor

1 reference

https://api.crossref.org/works/10.1074/JBC.M001847200

21 January 2018

High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis

1 reference

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Interaction of vasculotropin/vascular endothelial cell growth factor with human umbilical vein endothelial cells: Binding, internalization, degradation, and biological effects

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Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

1 reference

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Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium

1 reference

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Identification of vascular endothelial growth factor determinants for binding KDR and FLT-1 receptors. Generation of receptor-selective VEGF variants by site-directed mutagenesis

1 reference

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21 January 2018

Vascular endothelial cell growth factor promotes tyrosine phosphorylation of mediators of signal transduction that contain SH2 domains. Association with endothelial cell proliferation.

1 reference

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The Phosphorylated 1169-Tyrosine Containing Region of Flt-1 Kinase (VEGFR-1) Is a Major Binding Site for PLCγ

1 reference

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21 January 2018

Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth

1 reference

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Vascular endothelial growth factor stimulates tyrosine phosphorylation and recruitment to new focal adhesions of focal adhesion kinase and paxillin in endothelial cells

1 reference

https://api.crossref.org/works/10.1074/JBC.M001847200

21 January 2018

The vascular endothelial growth factor receptor KDR activates multiple signal transduction pathways in porcine aortic endothelial cells

1 reference

https://api.crossref.org/works/10.1074/JBC.M001847200

21 January 2018

The 230 kDa mature form of KDR/Flk-1 (VEGF receptor-2) activates the PLC-gamma pathway and partially induces mitotic signals in NIH3T3 fibroblasts

1 reference

https://api.crossref.org/works/10.1074/JBC.M001847200

21 January 2018

Identification of vascular endothelial growth factor receptor-1 tyrosine phosphorylation sites and binding of SH2 domain-containing molecules

1 reference

https://api.crossref.org/works/10.1074/JBC.M001847200

21 January 2018

VRAP is an adaptor protein that binds KDR, a receptor for vascular endothelial cell growth factor

1 reference

https://api.crossref.org/works/10.1074/JBC.M001847200

21 January 2018

Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria

1 reference

https://api.crossref.org/works/10.1074/JBC.M001847200

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Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphenylglycoluril

1 reference

https://api.crossref.org/works/10.1074/JBC.M001847200

21 January 2018

Homologous up-regulation of KDR/Flk-1 receptor expression by vascular endothelial growth factor in vitro.

1 reference

https://api.crossref.org/works/10.1074/JBC.M001847200

21 January 2018

Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

1 reference

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Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

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Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis

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Overexpression of vascular permeability factor/vascular endothelial growth factor and its receptors in psoriasis

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Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders

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Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

1 reference

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Regulation of VEGF/VPF expression in tumor cells: consequences for tumor growth and metastasis

1 reference

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Hypoxia-induced paracrine regulation of vascular endothelial growth factor receptor expression

1 reference

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Induction of vascular endothelial growth factor by insulin-like growth factor 1 in colorectal carcinoma

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Coordinated induction of VEGF receptors in mesenchymal cell types during rat hepatic wound healing

1 reference

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21 January 2018

Increased gene expression for VEGF and the VEGF receptors KDR/Flk and Flt in lungs exposed to acute or to chronic hypoxia. Modulation of gene expression by nitric oxide

1 reference

https://api.crossref.org/works/10.1074/JBC.M001847200

21 January 2018

Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes. Flt-1, but not Flk-1/KDR, is up-regulated by hypoxia.

1 reference

https://api.crossref.org/works/10.1074/JBC.M001847200

21 January 2018

p38 MAP kinase activation by vascular endothelial growth factor mediates actin reorganization and cell migration in human endothelial cells

1 reference

https://api.crossref.org/works/10.1074/JBC.M001847200

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Scatter factor induces blood vessel formation in vivo

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Tumor necrosis factor-alpha regulates expression of vascular endothelial growth factor receptor-2 and of its co-receptor neuropilin-1 in human vascular endothelial cells.

1 reference

https://api.crossref.org/works/10.1074/JBC.M001847200

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Downregulation of vascular endothelial growth factor receptors by tumor necrosis factor-alpha in cultured human vascular endothelial cells

1 reference

https://api.crossref.org/works/10.1074/JBC.M001847200

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Transforming growth factor beta 1 down-regulates vascular endothelial growth factor receptor 2/flk-1 expression in vascular endothelial cells.

1 reference

https://api.crossref.org/works/10.1074/JBC.M001847200

21 January 2018

Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation

1 reference

https://api.crossref.org/works/10.1074/JBC.M001847200

21 January 2018

The Vascular Endothelial Growth Factor Receptor Flt-1 Mediates Biological Activities

1 reference

https://api.crossref.org/works/10.1074/JBC.M001847200

21 January 2018

Expression of transforming growth factor alpha messenger RNA in the normal and neoplastic gastro-intestinal tract

1 reference

https://api.crossref.org/works/10.1074/JBC.M001847200

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Vascular endothelial growth factor and glioma angiogenesis: coordinate induction of VEGF receptors, distribution of VEGF protein and possible in vivo regulatory mechanisms

1 reference

https://api.crossref.org/works/10.1074/JBC.M001847200

7 January 2021

based on heuristic

inferred from DOI database lookup

MAP kinases, phosphatidylinositol 3-kinase, and p70 S6 kinase mediate the mitogenic response of human endothelial cells to vascular endothelial growth factor

1 reference

https://api.crossref.org/works/10.1074/JBC.M001847200

7 January 2021

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Regulation of vascular endothelial growth factor expression in cultured keratinocytes. Implications for normal and impaired wound healing

1 reference

https://api.crossref.org/works/10.1074/JBC.M001847200

7 January 2021

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inferred from DOI database lookup

Tumor necrosis factor employs a protein-tyrosine phosphatase to inhibit activation of KDR and vascular endothelial cell growth factor-induced endothelial cell proliferation

1 reference

https://api.crossref.org/works/10.1074/JBC.M001847200

7 January 2021

based on heuristic

inferred from DOI database lookup

Utilization of distinct signaling pathways by receptors for vascular endothelial cell growth factor and other mitogens in the induction of endothelial cell proliferation

1 reference

https://api.crossref.org/works/10.1074/JBC.M001847200

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based on heuristic

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Vascular permeability factor, an endothelial cell mitogen related to PDGF

1 reference

https://api.crossref.org/works/10.1074/JBC.M001847200

7 January 2021

based on heuristic

inferred from DOI database lookup

Expression of vascular permeability factor/vascular endothelial growth factor in normal rat tissues

1 reference

https://api.crossref.org/works/10.1074/JBC.M001847200

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based on heuristic

inferred from DOI database lookup

Functional upregulation of the vascular endothelial growth factor receptor KDR by hypoxia

1 reference

https://api.crossref.org/works/10.1074/JBC.M001847200

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Comparative analysis of vascular endothelial growth factor receptors on retinal and aortic vascular endothelial cells

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7 January 2021

based on heuristic

inferred from DOI database lookup

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10.1074/JBC.M001847200

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