(Q21991653)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P97469

Zinc finger C2H2-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97469

1 reference

8 April 2019

chromatin binding

1 reference

8 April 2019

Adipose tissue mass is modulated by SLUG (SNAI2)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97469

transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding

1 reference

11 October 2018

Genome-wide B1 retrotransposon binds the transcription factors dioxin receptor and Slug and regulates gene expression in vivo

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97469&geneProductId=UniProtKB:P97469

DNA binding

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97469&geneProductId=UniProtKB:P97469

1 reference

27 March 2018

nucleic acid binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97469

1 reference

8 April 2019

protein binding

IPI

1 reference

8 April 2019

Ajuba LIM proteins are snail/slug corepressors required for neural crest development in Xenopus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97469

DNA-binding transcription repressor activity, RNA polymerase II-specific

IPI

3 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97469&geneProductId=UniProtKB:P97469

27 March 2018

Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97469&geneProductId=UniProtKB:P97469

27 March 2018

Slug is a direct Notch target required for initiation of cardiac cushion cellularization

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97469&geneProductId=UniProtKB:P97469

sequence-specific DNA binding

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97469&geneProductId=UniProtKB:P97469

RNA polymerase II transcription regulatory region sequence-specific DNA binding

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97469&geneProductId=UniProtKB:P97469

DNA-binding transcription repressor activity, RNA polymerase II-specific

8 references

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97469&geneProductId=UniProtKB:P97469

11 October 2018

Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97469&geneProductId=UniProtKB:P97469

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97469&geneProductId=UniProtKB:P97469

11 October 2018

Slug is a direct Notch target required for initiation of cardiac cushion cellularization

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97469&geneProductId=UniProtKB:P97469

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97469

8 April 2019

Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97469

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97469

8 April 2019

Slug is a direct Notch target required for initiation of cardiac cushion cellularization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97469

DNA-binding transcription repressor activity, RNA polymerase II-specific

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97469&geneProductId=UniProtKB:P97469

DNA-binding transcription factor activity

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97469

E-box binding

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97469&geneProductId=UniProtKB:P97469

DNA-binding transcription factor activity, RNA polymerase II-specific

1 reference

8 April 2019

Genome-wide B1 retrotransposon binds the transcription factors dioxin receptor and Slug and regulates gene expression in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97469

cell component

nucleus

4 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97469&geneProductId=UniProtKB:P97469

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97469&geneProductId=UniProtKB:P97469

27 March 2018

27 March 2018

SNAI1 and SNAI2 are asymmetrically expressed at the 2-cell stage and become segregated to the TE in the mouse blastocyst

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97469&geneProductId=UniProtKB:P97469

27 March 2018

The radioresistance biological function of the SCF/kit signaling pathway is mediated by the zinc-finger transcription factor Slug

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97469&geneProductId=UniProtKB:P97469

nucleus

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97469

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97469

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97469

8 April 2019

SNAI1 and SNAI2 are asymmetrically expressed at the 2-cell stage and become segregated to the TE in the mouse blastocyst

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97469

8 April 2019

The radioresistance biological function of the SCF/kit signaling pathway is mediated by the zinc-finger transcription factor Slug

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97469

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97469

biological process

response to radiation

negative regulation of apoptotic process

1 reference

8 April 2019

Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97469

regulation of apoptotic process

1 reference

8 April 2019

The radioresistance biological function of the SCF/kit signaling pathway is mediated by the zinc-finger transcription factor Slug

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97469

transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97469&geneProductId=UniProtKB:P97469

1 reference

27 March 2018

negative regulation of stem cell proliferation

1 reference

8 April 2019

Slug deficiency enhances self-renewal of hematopoietic stem cells during hematopoietic regeneration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97469

multicellular organism development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97469

1 reference

8 April 2019

cartilage morphogenesis

1 reference

8 April 2019

Multiple functions of Snail family genes during palate development in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97469

cellular response to fibroblast growth factor stimulus

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97469&geneProductId=UniProtKB:P97469

epithelium development

1 reference

8 April 2019

Erk5 controls Slug expression and keratinocyte activation during wound healing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97469

wound healing, spreading of cells

1 reference

8 April 2019

Slug is a direct Notch target required for initiation of cardiac cushion cellularization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97469

negative regulation of cell adhesion involved in substrate-bound cell migration

1 reference

8 April 2019

Slug is a direct Notch target required for initiation of cardiac cushion cellularization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97469

cellular response to ionizing radiation

1 reference

8 April 2019

Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97469

positive regulation of endothelial cell chemotaxis

1 reference

8 April 2019

Slug is a direct Notch target required for initiation of cardiac cushion cellularization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97469

regulation of branching involved in salivary gland morphogenesis

1 reference

8 April 2019

Btbd7 regulates epithelial cell dynamics and branching morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97469

white fat cell differentiation

1 reference

8 April 2019

Adipose tissue mass is modulated by SLUG (SNAI2)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97469

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

2 references

8 April 2019

SLUG, a ces-1-related zinc finger transcription factor gene with antiapoptotic activity, is a downstream target of the E2A-HLF oncoprotein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97469

8 April 2019

SLUG, a ces-1-related zinc finger transcription factor gene with antiapoptotic activity, is a downstream target of the E2A-HLF oncoprotein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97469

positive regulation of histone acetylation

1 reference

8 April 2019

Adipose tissue mass is modulated by SLUG (SNAI2)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97469

cellular response to platelet-derived growth factor stimulus

1 reference

8 April 2019

Slug is a direct Notch target required for initiation of cardiac cushion cellularization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97469

regulation of transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97469&geneProductId=UniProtKB:P97469

1 reference

27 March 2018

cell migration

1 reference

8 April 2019

Multiple functions of Snail family genes during palate development in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97469

cell migration involved in endocardial cushion formation

1 reference

8 April 2019

Slug is a direct Notch target required for initiation of cardiac cushion cellularization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97469

epithelial to mesenchymal transition involved in endocardial cushion formation

negative regulation of transcription by RNA polymerase II

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97469

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97469

8 April 2019

Genome-wide B1 retrotransposon binds the transcription factors dioxin receptor and Slug and regulates gene expression in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97469

epithelial to mesenchymal transition

3 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97469&geneProductId=UniProtKB:P97469

27 March 2018

Snai2 expression enhances ultraviolet radiation-induced skin carcinogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97469&geneProductId=UniProtKB:P97469

27 March 2018

The zinc-finger protein slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97469&geneProductId=UniProtKB:P97469

negative regulation of keratinocyte proliferation

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97469&geneProductId=UniProtKB:P97469

negative regulation of vitamin D biosynthetic process

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97469&geneProductId=UniProtKB:P97469

neural crest cell development

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97469&geneProductId=UniProtKB:P97469

positive regulation of cell migration

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97469&geneProductId=UniProtKB:P97469

negative regulation of chondrocyte differentiation

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97469&geneProductId=UniProtKB:P97469

regulation of chemokine production

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97469&geneProductId=UniProtKB:P97469

negative regulation of DNA damage response, signal transduction by p53 class mediator

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97469&geneProductId=UniProtKB:P97469

regulation of osteoblast differentiation

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97469&geneProductId=UniProtKB:P97469

canonical Wnt signaling pathway

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97469&geneProductId=UniProtKB:P97469

negative regulation of vitamin D receptor signaling pathway

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97469&geneProductId=UniProtKB:P97469

cellular response to epidermal growth factor stimulus

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97469&geneProductId=UniProtKB:P97469

negative regulation of canonical Wnt signaling pathway

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97469&geneProductId=UniProtKB:P97469

negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97469&geneProductId=UniProtKB:P97469

regulation of bicellular tight junction assembly

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97469&geneProductId=UniProtKB:P97469

negative regulation of anoikis

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97469&geneProductId=UniProtKB:P97469

osteoblast differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97469

epithelial to mesenchymal transition

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97469

8 April 2019

Snai2 expression enhances ultraviolet radiation-induced skin carcinogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97469

8 April 2019

The zinc-finger protein slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97469

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97469

regulation of transcription, DNA-templated

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97469

Notch signaling pathway

3 references

desmosome disassembly

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97469

8 April 2019

The zinc-finger protein slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97469

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97469

pigmentation

3 references

Zinc finger C2H2-type

1 reference

InterPro Release 71.0