(Q21983260)

membrane protein

1 reference

inferred from GOA cell component → membrane

Frizzled/Smoothened, transmembrane domain, protein family

1 reference

inferred from protein domain or family

GPCR, family 2-like

1 reference

inferred from protein domain or family

Frizzled domain, protein family

1 reference

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

signal transducer activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=O70421&geneProductId=UniProtKB:O70421

1 reference

24 April 2018

Wnt-protein binding

3 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O70421&geneProductId=UniProtKB:O70421

24 April 2018

Wnt7b activates canonical signaling in epithelial and vascular smooth muscle cells through interactions with Fzd1, Fzd10, and LRP5.

http://www.ebi.ac.uk/QuickGO/annotations?protein=O70421&geneProductId=UniProtKB:O70421

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O70421&geneProductId=UniProtKB:O70421

transmembrane signaling receptor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70421

1 reference

14 February 2019

Wnt-activated receptor activity

Parkinsons Disease Gene Ontology Initiative

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70421

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70421

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70421

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70421

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70421

identical protein binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70421

protein homodimerization activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70421

protein heterodimerization activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70421

G protein-coupled receptor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70421

1 reference

14 February 2019

Wnt-protein binding

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70421

14 February 2019

Wnt7b activates canonical signaling in epithelial and vascular smooth muscle cells through interactions with Fzd1, Fzd10, and LRP5.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70421

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70421

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70421

cell component

membrane

integral component of membrane

2 references

neuron projection

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70421

plasma membrane

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70421

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70421

14 February 2019

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70421

G protein-coupled receptor signaling pathway

biological process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70421

1 reference

14 February 2019

positive regulation of protein phosphorylation

1 reference

14 February 2019

Wnt proteins induce dishevelled phosphorylation via an LRP5/6- independent mechanism, irrespective of their ability to stabilize beta-catenin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70421

epithelial cell differentiation

The stomach mesenchymal transcription factor Barx1 specifies gastric epithelial identity through inhibition of transient Wnt signaling

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70421

14 February 2019

The stomach mesenchymal transcription factor Barx1 specifies gastric epithelial identity through inhibition of transient Wnt signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70421

muscular septum morphogenesis

1 reference

14 February 2019

Frizzled 1 and frizzled 2 genes function in palate, ventricular septum and neural tube closure: general implications for tissue fusion processes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70421

ventricular septum morphogenesis

1 reference

14 February 2019

Frizzled 1 and frizzled 2 genes function in palate, ventricular septum and neural tube closure: general implications for tissue fusion processes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70421

cell-cell signaling

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70421

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70421

14 February 2019

The stomach mesenchymal transcription factor Barx1 specifies gastric epithelial identity through inhibition of transient Wnt signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70421

membranous septum morphogenesis

1 reference

14 February 2019

Frizzled 1 and frizzled 2 genes function in palate, ventricular septum and neural tube closure: general implications for tissue fusion processes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70421

outflow tract morphogenesis

1 reference

14 February 2019

Frizzled 1 and frizzled 2 genes function in palate, ventricular septum and neural tube closure: general implications for tissue fusion processes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70421

planar cell polarity pathway involved in neural tube closure

1 reference

14 February 2019

Frizzled 1 and frizzled 2 genes function in palate, ventricular septum and neural tube closure: general implications for tissue fusion processes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70421

negative regulation of BMP signaling pathway

1 reference

14 February 2019

Murine Frizzled-1 behaves as an antagonist of the canonical Wnt/beta-catenin signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70421

multicellular organism development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70421

1 reference

14 February 2019

cell surface receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70421

1 reference

14 February 2019

hard palate development

1 reference

14 February 2019

Frizzled 1 and frizzled 2 genes function in palate, ventricular septum and neural tube closure: general implications for tissue fusion processes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70421

canonical Wnt signaling pathway

3 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O70421&geneProductId=UniProtKB:O70421

24 April 2018

Wnt proteins induce dishevelled phosphorylation via an LRP5/6- independent mechanism, irrespective of their ability to stabilize beta-catenin

http://www.ebi.ac.uk/QuickGO/annotations?protein=O70421&geneProductId=UniProtKB:O70421

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O70421&geneProductId=UniProtKB:O70421

negative regulation of transcription, DNA-templated

1 reference

14 February 2019

The Wnt/beta-catenin pathway regulates Gli-mediated Myf5 expression during somitogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70421

signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70421

1 reference

14 February 2019

negative regulation of oxidative stress-induced neuron death

1 reference

14 February 2019

A Wnt1 regulated Frizzled-1/β-Catenin signaling pathway as a candidate regulatory circuit controlling mesencephalic dopaminergic neuron-astrocyte crosstalk: Therapeutical relevance for neuron survival and neuroprotection

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70421

negative regulation of canonical Wnt signaling pathway

1 reference

14 February 2019

Murine Frizzled-1 behaves as an antagonist of the canonical Wnt/beta-catenin signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70421

positive regulation of neuron projection development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70421

Wnt signaling pathway

4 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O70421&geneProductId=UniProtKB:O70421

24 April 2018

Wnt7b activates canonical signaling in epithelial and vascular smooth muscle cells through interactions with Fzd1, Fzd10, and LRP5.

http://www.ebi.ac.uk/QuickGO/annotations?protein=O70421&geneProductId=UniProtKB:O70421

http://www.ebi.ac.uk/QuickGO/annotations?protein=O70421&geneProductId=UniProtKB:O70421

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O70421&geneProductId=UniProtKB:O70421

24 April 2018

Wnt signaling pathway

non-canonical Wnt signaling pathway

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70421

canonical Wnt signaling pathway

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70421

14 February 2019

Wnt proteins induce dishevelled phosphorylation via an LRP5/6- independent mechanism, irrespective of their ability to stabilize beta-catenin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70421

14 February 2019

Wnt7b activates canonical signaling in epithelial and vascular smooth muscle cells through interactions with Fzd1, Fzd10, and LRP5.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70421

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70421

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70421

1 reference

GPCR, family 2-like

1 reference

Frizzled/Smoothened, transmembrane domain

1 reference