(Q21499173)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q80TQ2

Papain-like cysteine peptidase superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q80TQ2

membrane protein

1 reference

inferred from GOA cell component → membrane

Peptidase C19, ubiquitin carboxyl-terminal hydrolase family

1 reference

CAP Gly-rich domain, protein family

1 reference

Ubiquitin specific protease domain, protein family

1 reference

Ubiquitin specific protease, conserved site, protein family

1 reference

cysteine-type peptidase activity

1 reference

25 May 2022

1 reference

25 May 2022

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

1 reference

14 February 2019

metal ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

1 reference

14 February 2019

peptidase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

1 reference

14 February 2019

protein binding

5 references

14 February 2019

CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

14 February 2019

Regulation of T cell development by the deubiquitinating enzyme CYLD

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

14 February 2019

CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

14 February 2019

Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

14 February 2019

The E3 ligase Itch and deubiquitinase Cyld act together to regulate Tak1 and inflammation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

hydrolase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

1 reference

14 February 2019

Lys48-specific deubiquitinase activity

1 reference

14 February 2019

Regulation of T cell development by the deubiquitinating enzyme CYLD

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

thiol-dependent deubiquitinase

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q80TQ2&geneProductId=UniProtKB:Q80TQ2

4 references

16 July 2018

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q80TQ2&geneProductId=UniProtKB:Q80TQ2

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q80TQ2&geneProductId=UniProtKB:Q80TQ2

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q80TQ2&geneProductId=UniProtKB:Q80TQ2

16 July 2018

zinc ion binding

Lys63-specific deubiquitinase activity

4 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q80TQ2&geneProductId=UniProtKB:Q80TQ2

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q80TQ2&geneProductId=UniProtKB:Q80TQ2

16 July 2018

The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic steatohepatitis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q80TQ2&geneProductId=UniProtKB:Q80TQ2

16 July 2018

Regulation of T cell development by the deubiquitinating enzyme CYLD

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q80TQ2&geneProductId=UniProtKB:Q80TQ2

structural constituent of ribosome

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q80TQ2&geneProductId=UniProtKB:Q80TQ2

1 reference

16 July 2018

thiol-dependent deubiquitinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

5 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

14 February 2019

SPATA2 regulates the activation of RIPK1 by modulating linear ubiquitination.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

Lys63-specific deubiquitinase activity

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

14 February 2019

The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic steatohepatitis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

14 February 2019

Regulation of T cell development by the deubiquitinating enzyme CYLD

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

cell component

cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

1 reference

14 February 2019

ciliary basal body

1 reference

14 February 2019

The deubiquitinating enzyme CYLD controls apical docking of basal bodies in ciliated epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

cell projection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

1 reference

14 February 2019

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

1 reference

14 February 2019

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

1 reference

14 February 2019

spindle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

4 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

microtubule organizing center

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

1 reference

14 February 2019

ciliary tip

1 reference

14 February 2019

The deubiquitinating enzyme CYLD controls apical docking of basal bodies in ciliated epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

perinuclear region of cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

1 reference

14 February 2019

microtubule

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

1 reference

14 February 2019

cytoskeleton

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

1 reference

14 February 2019

centrosome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

4 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

cytoplasmic microtubule

ubiquitin-dependent protein catabolic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

1 reference

14 February 2019

Wnt signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

1 reference

14 February 2019

proteolysis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

1 reference

14 February 2019

regulation of cilium assembly

1 reference

14 February 2019

The deubiquitinating enzyme CYLD controls apical docking of basal bodies in ciliated epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

ripoptosome assembly involved in necroptotic process

1 reference

14 February 2019

Caspase 8 inhibits programmed necrosis by processing CYLD

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

negative regulation of T cell differentiation

1 reference

16 July 2018

The tumor suppressor CYLD controls the function of murine regulatory T cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q80TQ2&geneProductId=UniProtKB:Q80TQ2

protein K48-linked deubiquitination

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

CD4-positive or CD8-positive, alpha-beta T cell lineage commitment

1 reference

14 February 2019

Regulation of T cell development by the deubiquitinating enzyme CYLD

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

positive regulation of protein localization

1 reference

14 February 2019

Regulation of T cell development by the deubiquitinating enzyme CYLD

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

positive regulation of T cell receptor signaling pathway

1 reference

14 February 2019

Regulation of T cell development by the deubiquitinating enzyme CYLD

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

regulation of protein binding

1 reference

14 February 2019

Regulation of T cell development by the deubiquitinating enzyme CYLD

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

positive regulation of T cell differentiation

1 reference

14 February 2019

Regulation of T cell development by the deubiquitinating enzyme CYLD

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

regulation of B cell differentiation

1 reference

14 February 2019

Regulation of T cell development by the deubiquitinating enzyme CYLD

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

homeostasis of number of cells

1 reference

14 February 2019

Regulation of T cell development by the deubiquitinating enzyme CYLD

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

immune system process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

1 reference

14 February 2019

regulation of mitotic cell cycle

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

regulation of tumor necrosis factor-mediated signaling pathway

negative regulation of NF-kappaB transcription factor activity

3 references

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

4 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

innate immune response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

4 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

protein K63-linked deubiquitination

negative regulation of canonical Wnt signaling pathway

3 references

protein linear deubiquitination

positive regulation of extrinsic apoptotic signaling pathway

3 references

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

regulation of intrinsic apoptotic signaling pathway

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

regulation of T cell receptor signaling pathway

1 reference

14 February 2019

Usp12 stabilizes the T-cell receptor complex at the cell surface during signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

cytoplasmic translation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q80TQ2&geneProductId=UniProtKB:Q80TQ2

1 reference

16 July 2018

negative regulation of NIK/NF-kappaB signaling

protein deubiquitination

Caspase 8 inhibits programmed necrosis by processing CYLD

4 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q80TQ2&geneProductId=UniProtKB:Q80TQ2

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q80TQ2&geneProductId=UniProtKB:Q80TQ2

21 June 2018

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q80TQ2&geneProductId=UniProtKB:Q80TQ2

21 June 2018

The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic steatohepatitis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q80TQ2&geneProductId=UniProtKB:Q80TQ2

protein K63-linked deubiquitination

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q80TQ2&geneProductId=UniProtKB:Q80TQ2

4 references

16 July 2018

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q80TQ2&geneProductId=UniProtKB:Q80TQ2

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q80TQ2&geneProductId=UniProtKB:Q80TQ2

16 July 2018

The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic steatohepatitis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q80TQ2&geneProductId=UniProtKB:Q80TQ2

protein deubiquitination

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

14 February 2019

Caspase 8 inhibits programmed necrosis by processing CYLD

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

14 February 2019

The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic steatohepatitis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

negative regulation of JNK cascade

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

14 February 2019

The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic steatohepatitis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

negative regulation of p38MAPK cascade

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

14 February 2019

The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic steatohepatitis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

regulation of tumor necrosis factor-mediated signaling pathway

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

14 February 2019

SPATA2 regulates the activation of RIPK1 by modulating linear ubiquitination.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

necroptosis

cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

IGI

14 February 2019

Caspase 8 inhibits programmed necrosis by processing CYLD

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

IGI

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

protein K63-linked deubiquitination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

5 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

14 February 2019

The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic steatohepatitis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

protein linear deubiquitination

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

14 February 2019

SPATA2 regulates the activation of RIPK1 by modulating linear ubiquitination.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

regulation of inflammatory response

regulation of necroptotic process

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2

14 February 2019

SPATA2 regulates the activation of RIPK1 by modulating linear ubiquitination.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80TQ2