(Q21498757)

Protein kinase-like domain superfamily

1 reference

SH2 domain superfamily

1 reference

F-actin binding domain, protein family

1 reference

Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family

1 reference

SH2 domain, protein family

1 reference

Tyrosine-protein kinase ABL, SH2 domain, protein family

1 reference

SH3 domain, protein family

1 reference

Protein kinase domain, protein family

1 reference

Protein kinase, ATP binding site, protein family

1 reference

Tyrosine-protein kinase, catalytic domain, protein family

1 reference

Tyrosine-protein kinase, active site, protein family

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

English

molecular function

transferase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

1 reference

14 February 2019

nucleotide binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

1 reference

14 February 2019

protein kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

1 reference

14 February 2019

non-membrane spanning protein tyrosine kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

14 February 2019

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

metal ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

1 reference

14 February 2019

kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

1 reference

14 February 2019

protein tyrosine kinase activity

11 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

14 February 2019

Adhesion-dependent regulation of p190RhoGAP in the developing brain by the Abl-related gene tyrosine kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

14 February 2019

SHP-2 is a novel target of Abl kinases during cell proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

14 February 2019

Abelson family kinases regulate Frizzled planar cell polarity signaling via Dsh phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

14 February 2019

14 February 2019

Two distinct phosphorylation pathways have additive effects on Abl family kinase activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

14 February 2019

Adhesion-dependent regulation of p190RhoGAP in the developing brain by the Abl-related gene tyrosine kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

14 February 2019

Arg interacts with cortactin to promote adhesion-dependent cell edge protrusion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

14 February 2019

SHP-2 is a novel target of Abl kinases during cell proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

14 February 2019

Abl family kinases regulate FcγR-mediated phagocytosis in murine macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

signaling receptor binding

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q4JIM5&geneProductId=UniProtKB:Q4JIM5

1 reference

27 March 2018

phosphotyrosine residue binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

cell component

cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

1 reference

14 February 2019

extrinsic component of cytoplasmic side of plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q4JIM5&geneProductId=UniProtKB:Q4JIM5

1 reference

27 March 2018

dendritic spine

1 reference

14 February 2019

Abl2/Arg controls dendritic spine and dendrite arbor stability via distinct cytoskeletal control pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

actin cytoskeleton

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

phagocytic cup

1 reference

14 February 2019

Abl family kinases regulate FcγR-mediated phagocytosis in murine macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

cytoskeleton

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

1 reference

14 February 2019

lamellipodium

1 reference

14 February 2019

Arg interacts with cortactin to promote adhesion-dependent cell edge protrusion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

cytoplasmic vesicle

TAS

1 reference

14 February 2019

Localization and phosphorylation of Abl-interactor proteins, Abi-1 and Abi-2, in the developing nervous system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

TAS

glutamatergic synapse

Disruption of Coordinated Presynaptic and Postsynaptic Maturation Underlies the Defects in Hippocampal Synapse Stability and Plasticity in Abl2/Arg-Deficient Mice

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

14 February 2019

Abl2/Arg controls dendritic spine and dendrite arbor stability via distinct cytoskeletal control pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

14 February 2019

Disruption of Coordinated Presynaptic and Postsynaptic Maturation Underlies the Defects in Hippocampal Synapse Stability and Plasticity in Abl2/Arg-Deficient Mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

14 February 2019

Abl2/Arg controls dendritic spine and dendrite arbor stability via distinct cytoskeletal control pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

EXP

biological process

visual learning

1 reference

14 February 2019

Integrin β1 signals through Arg to regulate postnatal dendritic arborization, synapse density, and behavior

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

cellular response to retinoic acid

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

cerebellum morphogenesis

1 reference

14 February 2019

Abl family tyrosine kinases are essential for basement membrane integrity and cortical lamination in the cerebellum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

negative regulation of endothelial cell apoptotic process

1 reference

14 February 2019

Abl kinases are required for vascular function, Tie2 expression, and angiopoietin-1-mediated survival

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

epidermal growth factor receptor signaling pathway

1 reference

14 February 2019

SHP-2 is a novel target of Abl kinases during cell proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

negative regulation of cell-cell adhesion

1 reference

14 February 2019

Abl family kinases regulate endothelial barrier function in vitro and in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

1 reference

14 February 2019

dendrite morphogenesis

Abl2/Arg controls dendritic spine and dendrite arbor stability via distinct cytoskeletal control pathways

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

14 February 2019

Integrin β1 signals through Arg to regulate postnatal dendritic arborization, synapse density, and behavior

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

14 February 2019

Abl2/Arg controls dendritic spine and dendrite arbor stability via distinct cytoskeletal control pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

positive regulation of phospholipase C activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

actin filament organization

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

positive regulation of cytosolic calcium ion concentration

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

neuron remodeling

1 reference

14 February 2019

Loss of dendrite stabilization by the Abl-related gene (Arg) kinase regulates behavioral flexibility and sensitivity to cocaine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

substrate-dependent cell migration, cell extension

1 reference

14 February 2019

Arg interacts with cortactin to promote adhesion-dependent cell edge protrusion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

positive regulation of oxidoreductase activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

negative regulation of Rho protein signal transduction

3 references

14 February 2019

Integrin β1 signals through Arg to regulate postnatal dendritic arborization, synapse density, and behavior

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

14 February 2019

Adhesion-dependent regulation of p190RhoGAP in the developing brain by the Abl-related gene tyrosine kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

14 February 2019

Integrin α3 is required for late postnatal stability of dendrite arbors, dendritic spines and synapses, and mouse behavior

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

learning

1 reference

14 February 2019

Loss of dendrite stabilization by the Abl-related gene (Arg) kinase regulates behavioral flexibility and sensitivity to cocaine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

actin filament bundle assembly

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

dendritic spine maintenance

cell adhesion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

1 reference

14 February 2019

regulation of cell population proliferation

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

exploration behavior

1 reference

14 February 2019

Integrin α3 is required for late postnatal stability of dendrite arbors, dendritic spines and synapses, and mouse behavior

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

positive regulation of ERK1 and ERK2 cascade

1 reference

14 February 2019

SHP-2 is a novel target of Abl kinases during cell proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

peptidyl-tyrosine autophosphorylation

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

positive regulation of I-kappaB kinase/NF-kappaB signaling

1 reference

14 February 2019

Defective T cell development and function in the absence of Abelson kinases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

alpha-beta T cell differentiation

1 reference

14 February 2019

Defective T cell development and function in the absence of Abelson kinases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

Bergmann glial cell differentiation

1 reference

14 February 2019

Abl family tyrosine kinases are essential for basement membrane integrity and cortical lamination in the cerebellum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

regulation of extracellular matrix organization

1 reference

14 February 2019

Abl family tyrosine kinases are essential for basement membrane integrity and cortical lamination in the cerebellum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

platelet-derived growth factor receptor signaling pathway

1 reference

14 February 2019

SHP-2 is a novel target of Abl kinases during cell proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

positive regulation of Wnt signaling pathway, planar cell polarity pathway

1 reference

14 February 2019

Abelson family kinases regulate Frizzled planar cell polarity signaling via Dsh phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

positive regulation of protein binding

1 reference

14 February 2019

Adhesion-dependent regulation of p190RhoGAP in the developing brain by the Abl-related gene tyrosine kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

innate immune response

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q4JIM5&geneProductId=UniProtKB:Q4JIM5

1 reference

27 March 2018

neural tube closure

1 reference

14 February 2019

Essential roles for the Abl and Arg tyrosine kinases in neurulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

aggressive behavior

1 reference

14 February 2019

Essential roles for the Abl and Arg tyrosine kinases in neurulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

adult walking behavior

1 reference

14 February 2019

Essential roles for the Abl and Arg tyrosine kinases in neurulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

post-embryonic development

1 reference

14 February 2019

Essential roles for the Abl and Arg tyrosine kinases in neurulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

reproductive process

1 reference

14 February 2019

Essential roles for the Abl and Arg tyrosine kinases in neurulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

actin cytoskeleton organization

neuron differentiation

1 reference

14 February 2019

Essential roles for the Abl and Arg tyrosine kinases in neurulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

auditory behavior

1 reference

14 February 2019

Essential roles for the Abl and Arg tyrosine kinases in neurulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

multicellular organism growth

1 reference

14 February 2019

Essential roles for the Abl and Arg tyrosine kinases in neurulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

neuromuscular process controlling balance

neuroepithelial cell differentiation

1 reference

14 February 2019

Essential roles for the Abl and Arg tyrosine kinases in neurulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

cell differentiation

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

synapse maturation

Disruption of Coordinated Presynaptic and Postsynaptic Maturation Underlies the Defects in Hippocampal Synapse Stability and Plasticity in Abl2/Arg-Deficient Mice

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

14 February 2019

Disruption of Coordinated Presynaptic and Postsynaptic Maturation Underlies the Defects in Hippocampal Synapse Stability and Plasticity in Abl2/Arg-Deficient Mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4JIM5

1 reference

tyrosine-protein kinase, catalytic domain

1 reference

tyrosine-protein kinase, active site

1 reference

F-actin binding

1 reference

serine-threonine/tyrosine-protein kinase, catalytic domain

1 reference

SH3 domain

1 reference

protein kinase, ATP binding site

1 reference

protein kinase domain

1 reference

Tyrosine-protein kinase ABL, SH2 domain

1 reference

Identifiers

1 reference

9 August 2016

1 reference

9 August 2016