(Q21495876)

English

Interleukin 17A

mammalian protein found in Mus musculus

interleukin-17A
cytotoxic T-lymphocyte-associated antigen 8
CTLA-8
Il17a

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Statements

1 reference

25 May 2022

1 reference

19 January 2017

Cystine-knot cytokine

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q62386

Interleukin-17, chordata

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q62386

1 reference

25 May 2022

1 reference

25 May 2022

external side of plasma membrane

determination method or standard

IDA

4 references

retrieved

9 May 2019

stated in

MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62386

determination method or standard

IDA

retrieved

9 May 2019

stated in

The transcription factor Th-POK negatively regulates Th17 differentiation in Vα14i NKT cells

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62386

determination method or standard

IDA

retrieved

9 May 2019

stated in

The sequential activity of Gata3 and Thpok is required for the differentiation of CD1d-restricted CD4 NKT cells

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62386

determination method or standard

IDA

retrieved

9 May 2019

stated in

Enforced expression of GATA3 allows differentiation of IL-17-producing cells, but constrains Th17-mediated pathology

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62386

determination method or standard

IDA

extracellular space

determination method or standard

6 references

9 May 2019

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62386

determination method or standard

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62386

determination method or standard

IEA

retrieved

9 May 2019

stated in

IL-17B and IL-17C are associated with TNF-alpha production and contribute to the exacerbation of inflammatory arthritis

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62386

determination method or standard

IDA

retrieved

9 May 2019

stated in

Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62386

determination method or standard

IDA

retrieved

9 May 2019

stated in

Toll-like receptor 2 modulates the proinflammatory milieu in Staphylococcus aureus-induced brain abscess

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62386

determination method or standard

IDA

retrieved

9 May 2019

stated in

IL-4 inhibits TGF-beta-induced Foxp3 T cells and, together with TGF-beta, generates IL-9 IL-10 Foxp3(-) effector T cells

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62386

determination method or standard

IDA

cytoplasm

determination method or standard

1 reference

9 May 2019

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62386

determination method or standard

ISO

biological process

positive regulation of cytokine production involved in inflammatory response

determination method or standard

IDA

IGI

cellular response to interleukin-1

determination method or standard

IDA

1 reference

retrieved

9 May 2019

stated in

IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62386

determination method or standard

IDA

positive regulation of transcription by RNA polymerase II

determination method or standard

3 references

9 May 2019

Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62386

determination method or standard

ISO

retrieved

9 May 2019

stated in

Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62386

determination method or standard

9 May 2019

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62386

determination method or standard

IEA

inflammatory response

determination method or standard

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62386

determination method or standard

IEA

regulation of signaling receptor activity

determination method or standard

1 reference

8 April 2019

Gene Ontology Consortium

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62386

determination method or standard

IEA

positive regulation of necrotic cell death

determination method or standard

1 reference

9 May 2019

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62386

determination method or standard

ISO

cellular response to glucocorticoid stimulus

determination method or standard

1 reference

9 May 2019

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62386

determination method or standard

ISO

positive regulation of interleukin-23 production

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62386

determination method or standard

ISO

positive regulation of osteoclast differentiation

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62386

determination method or standard

ISO

positive regulation of transcription by RNA polymerase II

determination method or standard

IGI

ISO

fibroblast activation

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62386

determination method or standard

ISO

granulocyte migration

determination method or standard

IGI

1 reference

retrieved

9 May 2019

stated in

Inflammation-induced proteolytic processing of the SIRPα cytoplasmic ITIM in neutrophils propagates a proinflammatory state.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62386

determination method or standard

IGI

signal transduction

determination method or standard

1 reference

9 May 2019

Gene Ontology Consortium

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62386

determination method or standard

IEA

Identifiers

1 reference

20 March 2022

1 reference

25 May 2022

1 reference

(Q21495876)

Interleukin 17A

Statements

Identifiers

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