(Q21495868)

Immunoglobulin-like fold

1 reference

interleukin-1 receptor type 1

1 reference

Immunoglobulin-like domain superfamily

1 reference

membrane protein

1 reference

inferred from GOA cell component → membrane

Immunoglobulin subtype, protein family

1 reference

inferred from protein domain or family

Toll/interleukin-1 receptor homology (TIR) domain, protein family

1 reference

inferred from protein domain or family

immunoglobulin-like domain, protein family

1 reference

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

interleukin-1, type I, activating receptor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

1 reference

9 May 2019

signal transducer activity

1 reference

24 April 2018

Identification of essential regions in the cytoplasmic tail of interleukin-1 receptor accessory protein critical for interleukin-1 signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13504&geneProductId=UniProtKB:P13504

protease binding

1 reference

9 May 2019

The enzymatic activity of ADAM8 and ADAM9 is not regulated by TIMPs

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

protein binding

4 references

9 May 2019

The role of interleukin 1 receptor-associated kinase-4 (IRAK-4) kinase activity in IRAK-4-mediated signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

9 May 2019

Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

9 May 2019

MyD88-dependent and -independent signaling by IL-1 in neurons probed by bifunctional Toll/IL-1 receptor domain/BB-loop mimetics

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

9 May 2019

Interleukin-1 (IL-1) receptor antagonist binds to the 80-kDa IL-1 receptor but does not initiate IL-1 signal transduction

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

interleukin-1 receptor activity

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

14 February 2019

Intracellular interleukin-1 receptor 2 binding prevents cleavage and activity of interleukin-1α, controlling necrosis-induced sterile inflammation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

14 February 2019

Ensembl genome database project

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

14 February 2019

Identification of essential regions in the cytoplasmic tail of interleukin-1 receptor accessory protein critical for interleukin-1 signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

interleukin-1 binding

1 reference

14 February 2019

Intracellular interleukin-1 receptor 2 binding prevents cleavage and activity of interleukin-1α, controlling necrosis-induced sterile inflammation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

ionotropic glutamate receptor binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

interleukin-1 receptor activity

6 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

9 May 2019

Intracellular interleukin-1 receptor 2 binding prevents cleavage and activity of interleukin-1α, controlling necrosis-induced sterile inflammation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

9 May 2019

Ensembl genome database project

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

9 May 2019

Identification of essential regions in the cytoplasmic tail of interleukin-1 receptor accessory protein critical for interleukin-1 signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

IBA

interleukin-1 binding

IBA

integral component of membrane

cell component

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

1 reference

9 May 2019

membrane

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

1 reference

9 May 2019

extracellular region

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

1 reference

9 May 2019

external side of plasma membrane

1 reference

9 May 2019

The transcription factor Th-POK negatively regulates Th17 differentiation in Vα14i NKT cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

extracellular space

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

nucleus

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

postsynaptic density

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

axon

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

protein-containing complex

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

cytokine-mediated signaling pathway

biological process

regulation of inflammatory response

1 reference

14 February 2019

Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

1 reference

9 May 2019

positive regulation of interleukin-1-mediated signaling pathway

1 reference

9 May 2019

Intracellular interleukin-1 receptor 2 binding prevents cleavage and activity of interleukin-1α, controlling necrosis-induced sterile inflammation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

positive regulation of neutrophil extravasation

1 reference

9 May 2019

Intracellular interleukin-1 receptor 2 binding prevents cleavage and activity of interleukin-1α, controlling necrosis-induced sterile inflammation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

response to radiation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

heat acclimation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

positive regulation of neuron migration

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

inflammatory response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

1 reference

9 May 2019

positive regulation of interferon-gamma production

positive regulation of T-helper 1 cell cytokine production

ISS

interleukin-1-mediated signaling pathway

ISS

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

Ensembl genome database project

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

IBA

has part(s)

immunoglobulin subtype

1 reference

immunoglobulin-like domain

1 reference

Toll/interleukin-1 receptor homology (TIR) domain

1 reference