Wikidata

(Q21494938)

English

Fas (TNF receptor superfamily member 6)

mammalian protein found in Mus musculus

  • Fas antigen
  • lymphoproliferation
  • apoptosis-mediating surface antigen FAS
  • tumor necrosis factor receptor superfamily member 6
  • Fas (TNF receptor superfamily member)
  • FASLG receptor
  • apo-1 antigen
  • Fas
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No label defined

No description defined

Statements

molecular function
protein binding
determination method or standard
IPI
12 references
retrieved
8 April 2019
stated in
Inhibition of both the extrinsic and intrinsic death pathways through nonhomotypic death-fold interactions
GOA
curator
UniProt
UniProt protein ID
P25446
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446
determination method or standard
IPI
retrieved
8 April 2019
stated in
FIST/HIPK3: a Fas/FADD-interacting serine/threonine kinase that induces FADD phosphorylation and inhibits fas-mediated Jun NH(2)-terminal kinase activation
GOA
curator
UniProt
UniProt protein ID
P25446
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446
determination method or standard
IPI
retrieved
8 April 2019
stated in
A Fas-associated protein factor, FAF1, potentiates Fas-mediated apoptosis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446
determination method or standard
IPI
retrieved
8 April 2019
stated in
A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446
determination method or standard
IPI
retrieved
8 April 2019
stated in
TGF-beta-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446
determination method or standard
IPI
retrieved
8 April 2019
stated in
Daxx, a Novel Fas-Binding Protein That Activates JNK and Apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446
determination method or standard
IPI
retrieved
8 April 2019
stated in
Caveolin-1 mediates Fas–BID signaling in hyperoxia-induced apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446
determination method or standard
IPI
retrieved
8 April 2019
stated in
FIST/HIPK3: a Fas/FADD-interacting serine/threonine kinase that induces FADD phosphorylation and inhibits fas-mediated Jun NH(2)-terminal kinase activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446
determination method or standard
IPI
retrieved
8 April 2019
stated in
The Fas-FADD death domain complex structure reveals the basis of DISC assembly and disease mutations
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446
determination method or standard
IPI
retrieved
8 April 2019
stated in
PMLRARα binds to Fas and suppresses Fas-mediated apoptosis through recruiting c-FLIP in vivo
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446
determination method or standard
IPI
retrieved
8 April 2019
stated in
Palmitoylation is required for efficient Fas cell death signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446
determination method or standard
IPI
retrieved
8 April 2019
stated in
TIPE2, a negative regulator of innate and adaptive immunity that maintains immune homeostasis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446
determination method or standard
IPI
cell component
external side of plasma membrane
determination method or standard
IDA
6 references
retrieved
8 April 2019
stated in
Distinct patterns of Fas cell surface expression during development of T- or B-lymphocyte lineages in normal, scid, and mutant mice lacking or overexpressing p53, bcl-2, or rag-2 genes
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446
determination method or standard
IDA
retrieved
8 April 2019
stated in
Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40 costimulator mRNAs and control follicular helper T cell differentiation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446
determination method or standard
IDA
retrieved
8 April 2019
stated in
M17, a gene specific for germinal center (GC) B cells and a prognostic marker for GC B-cell lymphomas, is dispensable for the GC reaction in mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446
determination method or standard
IDA
retrieved
8 April 2019
stated in
Raf-1 sets the threshold of Fas sensitivity by modulating Rok-alpha signaling
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446
determination method or standard
IDA
retrieved
8 April 2019
stated in
The mouse cell surface protein TOSO regulates Fas/Fas ligand-induced apoptosis through its binding to Fas-associated death domain
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446
determination method or standard
IDA
retrieved
8 April 2019
stated in
Cell-mediated fas-based lysis of dendritic cells which are apparently resistant to anti-Fas antibody
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446
determination method or standard
IDA
biological process
extrinsic apoptotic signaling pathway via death domain receptors
determination method or standard
IMP
IDA
IGI
12 references
retrieved
8 April 2019
stated in
Several different cell surface molecules control negative selection of medullary thymocytes
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446
determination method or standard
IMP
retrieved
8 April 2019
stated in
Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446
determination method or standard
IMP
retrieved
8 April 2019
stated in
Cell-mediated fas-based lysis of dendritic cells which are apparently resistant to anti-Fas antibody
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446
determination method or standard
IMP
retrieved
8 April 2019
stated in
A Fas-associated protein factor, FAF1, potentiates Fas-mediated apoptosis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446
determination method or standard
IMP
retrieved
8 April 2019
stated in
Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446
determination method or standard
IGI
retrieved
8 April 2019
stated in
Loss of the nf1 tumor suppressor gene decreases fas antigen expression in myeloid cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446
determination method or standard
IDA
retrieved
8 April 2019
stated in
The phosphoprotein protein PEA-15 inhibits Fas- but increases TNF-R1-mediated caspase-8 activity and apoptosis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446
determination method or standard
IDA
retrieved
8 April 2019
stated in
A Fas-associated protein factor, FAF1, potentiates Fas-mediated apoptosis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446
determination method or standard
IDA
retrieved
8 April 2019
stated in
The mouse cell surface protein TOSO regulates Fas/Fas ligand-induced apoptosis through its binding to Fas-associated death domain
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446
determination method or standard
IDA
retrieved
8 April 2019
stated in
Trps1 plays a pivotal role downstream of Gdf5 signaling in promoting chondrogenesis and apoptosis of ATDC5 cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446
determination method or standard
IDA
retrieved
8 April 2019
stated in
Cell-mediated fas-based lysis of dendritic cells which are apparently resistant to anti-Fas antibody
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446
determination method or standard
IDA
retrieved
8 April 2019
stated in
tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446
determination method or standard
IDA

Identifiers

 
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