Wikidata

(Q21123230)

English

Platelet derived growth factor subunit B

mammalian protein found in Homo sapiens

  • Platelet-derived growth factor beta polypeptide
  • epididymis secretory sperm binding protein
  • PDGF-2
  • platelet-derived growth factor 2
  • PDGF, B chain
  • proto-oncogene c-Sis
  • platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)
  • PDGFB
  • becaplermin
  • platelet-derived growth factor B chain
  • platelet-derived growth factor subunit B
  • platelet-derived growth factor, beta polypeptide (oncogene SIS)
  • PDGF subunit B
  • Proto-Oncogene Proteins c-sis
In more languages
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No label defined

No description defined

Statements

molecular function
protein binding
determination method or standard
IPI
7 references
retrieved
8 April 2019
stated in
Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell
GOA
curator
UniProt
UniProt protein ID
P01127
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01127
determination method or standard
IPI
retrieved
8 April 2019
stated in
PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01127
determination method or standard
IPI
retrieved
8 April 2019
stated in
Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01127
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01127
determination method or standard
IPI
retrieved
8 April 2019
stated in
Platelet-derived growth factor C (PDGF-C), a novel growth factor that binds to PDGF alpha and beta receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01127
determination method or standard
IPI
retrieved
8 April 2019
stated in
Mechanism of platelet-derived growth factor (PDGF) AA, AB, and BB binding to alpha and beta PDGF receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01127
determination method or standard
IPI
retrieved
8 April 2019
stated in
Isolation of a novel receptor cDNA establishes the existence of two PDGF receptor genes
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01127
determination method or standard
IPI
platelet-derived growth factor receptor binding
determination method or standard
IBA
IDA
IPI
NAS
5 references
retrieved
8 April 2019
stated in
Two PDGF-B chain residues, arginine 27 and isoleucine 30, mediate receptor binding and activation
GOA
curator
UniProt
UniProt protein ID
P01127
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01127
determination method or standard
NAS
retrieved
8 April 2019
stated in
Isolation of a novel receptor cDNA establishes the existence of two PDGF receptor genes
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01127
determination method or standard
IPI
retrieved
8 April 2019
stated in
A common PDGF receptor is activated by homodimeric A and B forms of PDGF
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01127
determination method or standard
IDA
retrieved
8 April 2019
stated in
PDGF induces c-myc mRNA expression in MG-63 human osteosarcoma cells but does not stimulate cell replication
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01127
determination method or standard
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01127
determination method or standard
IBA
cell component
biological process
positive regulation of DNA biosynthetic process
determination method or standard
IDA
7 references
retrieved
8 April 2019
stated in
Mitogenic signaling via platelet-derived growth factor beta in metanephric mesenchymal cells
GOA
curator
UniProt
UniProt protein ID
P01127
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01127
determination method or standard
IDA
retrieved
8 April 2019
stated in
Platelet-derived growth factor receptor beta regulates migration and DNA synthesis in metanephric mesenchymal cells
GOA
curator
UniProt
UniProt protein ID
P01127
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01127
determination method or standard
IDA
retrieved
8 April 2019
stated in
c-Src couples PI 3 kinase/Akt and MAPK signaling to PDGF-induced DNA synthesis in mesangial cells
GOA
curator
UniProt
UniProt protein ID
P01127
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01127
determination method or standard
IDA
retrieved
8 April 2019
stated in
Effect of platelet-derived growth factor isoforms in rat metanephric mesenchymal cells
GOA
curator
UniProt
UniProt protein ID
P01127
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01127
determination method or standard
IDA
retrieved
8 April 2019
stated in
PDGF receptor-{beta} modulates metanephric mesenchyme chemotaxis induced by PDGF AA
GOA
curator
UniProt
UniProt protein ID
P01127
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01127
determination method or standard
IDA
retrieved
8 April 2019
stated in
Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell
GOA
curator
UniProt
UniProt protein ID
P01127
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01127
determination method or standard
IDA
retrieved
8 April 2019
stated in
PSM, a mediator of PDGF-BB-, IGF-I-, and insulin-stimulated mitogenesis
GOA
curator
UniProt
UniProt protein ID
P01127
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01127
determination method or standard
IDA
platelet-derived growth factor receptor signaling pathway
determination method or standard
IDA
5 references
retrieved
1 January 2018
stated in
A common PDGF receptor is activated by homodimeric A and B forms of PDGF
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P01127&geneProductId=UniProtKB:P01127
determination method or standard
IDA
retrieved
1 January 2018
stated in
Neuropilin-1 signaling through p130Cas tyrosine phosphorylation is essential for growth factor-dependent migration of glioma and endothelial cells
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P01127&geneProductId=UniProtKB:P01127
determination method or standard
IDA
retrieved
1 January 2018
stated in
Isolation of a novel receptor cDNA establishes the existence of two PDGF receptor genes
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P01127&geneProductId=UniProtKB:P01127
determination method or standard
IDA
retrieved
1 January 2018
stated in
PDGF induces c-myc mRNA expression in MG-63 human osteosarcoma cells but does not stimulate cell replication
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P01127&geneProductId=UniProtKB:P01127
determination method or standard
IDA
retrieved
1 January 2018
stated in
Induction of microRNA-221 by platelet-derived growth factor signaling is critical for modulation of vascular smooth muscle phenotype
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P01127&geneProductId=UniProtKB:P01127
determination method or standard
IDA
positive regulation of MAP kinase activity
determination method or standard
IBA
IDA
5 references
retrieved
8 April 2019
stated in
c-Src couples PI 3 kinase/Akt and MAPK signaling to PDGF-induced DNA synthesis in mesangial cells
GOA
curator
UniProt
UniProt protein ID
P01127
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01127
determination method or standard
IDA
retrieved
8 April 2019
stated in
Mitogenic signaling via platelet-derived growth factor beta in metanephric mesenchymal cells
GOA
curator
UniProt
UniProt protein ID
P01127
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01127
determination method or standard
IDA
retrieved
8 April 2019
stated in
Effect of platelet-derived growth factor isoforms in rat metanephric mesenchymal cells
GOA
curator
UniProt
UniProt protein ID
P01127
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01127
determination method or standard
IDA
retrieved
8 April 2019
stated in
Apolipoprotein E inhibits platelet-derived growth factor-induced vascular smooth muscle cell migration and proliferation by suppressing signal transduction and preventing cell entry to G1 phase
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01127
determination method or standard
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01127
determination method or standard
IBA
platelet-derived growth factor receptor signaling pathway
determination method or standard
IBA
IDA
7 references
retrieved
8 April 2019
stated in
Induction of microRNA-221 by platelet-derived growth factor signaling is critical for modulation of vascular smooth muscle phenotype
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01127
determination method or standard
IDA
retrieved
8 April 2019
stated in
Neuropilin-1 signaling through p130Cas tyrosine phosphorylation is essential for growth factor-dependent migration of glioma and endothelial cells
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01127
determination method or standard
IDA
retrieved
8 April 2019
stated in
A common PDGF receptor is activated by homodimeric A and B forms of PDGF
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01127
determination method or standard
IDA
retrieved
8 April 2019
stated in
Isolation of a novel receptor cDNA establishes the existence of two PDGF receptor genes
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01127
determination method or standard
IDA
retrieved
8 April 2019
stated in
MicroRNA-638 is highly expressed in human vascular smooth muscle cells and inhibits PDGF-BB-induced cell proliferation and migration through targeting orphan nuclear receptor NOR1
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01127
determination method or standard
IDA
retrieved
8 April 2019
stated in
PDGF induces c-myc mRNA expression in MG-63 human osteosarcoma cells but does not stimulate cell replication
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01127
determination method or standard
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01127
determination method or standard
IBA

Identifiers

MeSH descriptor ID
D020574
subject named as
Proto-Oncogene Proteins c-sis
0 references
MeSH tree code
D12.644.276.910.650
0 references
D12.776.124.625.650
0 references
D12.776.260.690
0 references
D12.776.467.910.650
0 references
D23.529.910.650
0 references
 
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