(Q21116913)

PH-like domain superfamily

1 reference

protein kinase C mu-related

1 reference

pleckstrin homology domain, protein family

1 reference

Protein kinase C-like, phorbol ester/diacylglycerol-binding domain, protein family

1 reference

Diacylglycerol/phorbol-ester binding domain, protein family

1 reference

Protein kinase domain, protein family

1 reference

Protein kinase, ATP binding site, protein family

1 reference

Serine/threonine-protein kinase, active site, protein family

1 reference

1 reference

13 November 2019

1 reference

13 November 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

1 reference

8 April 2019

nucleotide binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

1 reference

8 April 2019

protein kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

1 reference

8 April 2019

protein kinase C activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

8 April 2019

8 April 2019

Tyrosine phosphorylation of protein kinase D in the pleckstrin homology domain leads to activation

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

metal ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

1 reference

8 April 2019

protein binding

9 references

8 April 2019

A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

8 April 2019

Centaurin-alpha(1) associates with and is phosphorylated by isoforms of protein kinase C

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

8 April 2019

PKD is a kinase of Vps34 that mediates ROS-induced autophagy downstream of DAPk

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

8 April 2019

Protein kinase C [micro] is regulated by the multifunctional chaperon protein p32

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

8 April 2019

E-cadherin phosphorylation by protein kinase D1/protein kinase C{mu} is associated with altered cellular aggregation and motility in prostate cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

8 April 2019

Regulation of PKD by the MAPK p38delta in insulin secretion and glucose homeostasis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

8 April 2019

Control of endothelial cell proliferation and migration by VEGF signaling to histone deacetylase 7.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

8 April 2019

Metallothionein 2A interacts with the kinase domain of PKCμ in prostate cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

8 April 2019

Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

identical protein binding

1 reference

8 April 2019

Protein kinase C [micro] is regulated by the multifunctional chaperon protein p32

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

protein serine/threonine kinase activity

PKCu is a novel, atypical member of the protein kinase C family

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

8 April 2019

Differential regulation of PKD isoforms in oxidative stress conditions through phosphorylation of a conserved Tyr in the P 1 loop

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

8 April 2019

8 April 2019

PKD is a kinase of Vps34 that mediates ROS-induced autophagy downstream of DAPk

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

8 April 2019

Vascular endothelial growth factor induces heat shock protein (HSP) 27 serine 82 phosphorylation and endothelial tubulogenesis via protein kinase D and independent of p38 kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

cell component

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

1 reference

8 April 2019

plasma membrane

integral component of plasma membrane

3 references

1 reference

24 April 2018

PKCu is a novel, atypical member of the protein kinase C family

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15139&geneProductId=UniProtKB:Q15139

autophagosome membrane

1 reference

8 April 2019

PKD is a kinase of Vps34 that mediates ROS-induced autophagy downstream of DAPk

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

1 reference

8 April 2019

trans-Golgi network

1 reference

8 April 2019

Protein kinase D controls the integrity of Golgi apparatus and the maintenance of dendritic arborization in hippocampal neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

cytosol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

4 references

8 April 2019

8 April 2019

Spatial and temporal regulation of protein kinase D (PKD)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

8 April 2019

negative regulation of endocytosis

biological process

1 reference

8 April 2019

Protein kinase D in vascular biology and angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

1 reference

8 April 2019

intracellular signal transduction

The zinc-finger transcription factor, early growth response 3, mediates VEGF-induced angiogenesis

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

8 April 2019

Vascular endothelial growth factor induces heat shock protein (HSP) 27 serine 82 phosphorylation and endothelial tubulogenesis via protein kinase D and independent of p38 kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

8 April 2019

positive regulation of endothelial cell proliferation

1 reference

8 April 2019

Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

regulation of protein stability

1 reference

8 April 2019

A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

Golgi organization

1 reference

8 April 2019

Protein kinase D controls the integrity of Golgi apparatus and the maintenance of dendritic arborization in hippocampal neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

1 reference

8 April 2019

immune system process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

1 reference

8 April 2019

positive regulation of endothelial cell chemotaxis

1 reference

8 April 2019

Vascular endothelial growth factor induces heat shock protein (HSP) 27 serine 82 phosphorylation and endothelial tubulogenesis via protein kinase D and independent of p38 kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

protein kinase D signaling

1 reference

24 April 2018

Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15139&geneProductId=UniProtKB:Q15139

sphingolipid biosynthetic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

1 reference

8 April 2019

negative regulation of cell death

1 reference

8 April 2019

Protein kinase D mediates a stress-induced NF-kappaB activation and survival pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

nervous system development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

1 reference

8 April 2019

positive regulation of peptidyl-serine phosphorylation

1 reference

8 April 2019

Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

positive regulation of angiogenesis

Protein kinase D-dependent phosphorylation and nuclear export of histone deacetylase 5 mediates vascular endothelial growth factor-induced gene expression and angiogenesis

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

8 April 2019

Vascular endothelial growth factor induces heat shock protein (HSP) 27 serine 82 phosphorylation and endothelial tubulogenesis via protein kinase D and independent of p38 kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

8 April 2019

Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

positive regulation of endothelial cell migration

1 reference

8 April 2019

Protein kinase D-dependent phosphorylation and nuclear export of histone deacetylase 5 mediates vascular endothelial growth factor-induced gene expression and angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

positive regulation of histone deacetylase activity

1 reference

8 April 2019

Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

positive regulation of CREB transcription factor activity

1 reference

8 April 2019

Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

vascular endothelial growth factor receptor signaling pathway

1 reference

8 April 2019

The zinc-finger transcription factor, early growth response 3, mediates VEGF-induced angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

regulation of integrin-mediated signaling pathway

1 reference

8 April 2019

Protein kinase D in vascular biology and angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

positive regulation of NF-kappaB transcription factor activity

1 reference

8 April 2019

Protein kinase D mediates a stress-induced NF-kappaB activation and survival pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

1 reference

8 April 2019

positive regulation of blood vessel endothelial cell migration

Vascular endothelial growth factor induces heat shock protein (HSP) 27 serine 82 phosphorylation and endothelial tubulogenesis via protein kinase D and independent of p38 kinase

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

8 April 2019

Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

positive regulation of neuron projection development

1 reference

8 April 2019

Protein kinase D controls the integrity of Golgi apparatus and the maintenance of dendritic arborization in hippocampal neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway

Vascular endothelial growth factor induces heat shock protein (HSP) 27 serine 82 phosphorylation and endothelial tubulogenesis via protein kinase D and independent of p38 kinase

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

8 April 2019

Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

positive regulation of I-kappaB kinase/NF-kappaB signaling

1 reference

8 April 2019

Protein kinase D mediates a stress-induced NF-kappaB activation and survival pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

integrin-mediated signaling pathway

1 reference

8 April 2019

Protein kinase D in vascular biology and angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

cellular response to oxidative stress

1 reference

8 April 2019

Protein kinase D mediates a stress-induced NF-kappaB activation and survival pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

cellular response to vascular endothelial growth factor stimulus

Protein kinase D-dependent phosphorylation and nuclear export of histone deacetylase 5 mediates vascular endothelial growth factor-induced gene expression and angiogenesis

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

8 April 2019

The zinc-finger transcription factor, early growth response 3, mediates VEGF-induced angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

8 April 2019

Vascular endothelial growth factor induces heat shock protein (HSP) 27 serine 82 phosphorylation and endothelial tubulogenesis via protein kinase D and independent of p38 kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

8 April 2019

Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

Ras protein signal transduction

1 reference

8 April 2019

A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

cell population proliferation

1 reference

1 January 2018

PKCu is a novel, atypical member of the protein kinase C family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

inflammatory response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

1 reference

8 April 2019

innate immune response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

1 reference

8 April 2019

signal transduction

1 reference

8 April 2019

PKCu is a novel, atypical member of the protein kinase C family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

positive regulation of transcription by RNA polymerase II

1 reference

8 April 2019

The zinc-finger transcription factor, early growth response 3, mediates VEGF-induced angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

apoptotic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

1 reference

8 April 2019

positive regulation of autophagy

1 reference

8 April 2019

PKD is a kinase of Vps34 that mediates ROS-induced autophagy downstream of DAPk

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

cellular response to amino acid starvation

1 reference

8 April 2019

PKD is a kinase of Vps34 that mediates ROS-induced autophagy downstream of DAPk

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

positive regulation of phosphatidylinositol 3-kinase activity

IC

1 reference

8 April 2019

PKD is a kinase of Vps34 that mediates ROS-induced autophagy downstream of DAPk

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

cellular response to hydroperoxide

IC

1 reference

8 April 2019

PKD is a kinase of Vps34 that mediates ROS-induced autophagy downstream of DAPk

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

regulation of keratinocyte proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

1 reference

8 April 2019

positive regulation of osteoblast differentiation

ISS

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

1 reference

8 April 2019

ISS

Golgi vesicle transport

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

1 reference

8 April 2019

peptidyl-serine phosphorylation

ISS

Differential regulation of PKD isoforms in oxidative stress conditions through phosphorylation of a conserved Tyr in the P 1 loop

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

8 April 2019

Vascular endothelial growth factor induces heat shock protein (HSP) 27 serine 82 phosphorylation and endothelial tubulogenesis via protein kinase D and independent of p38 kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15139

peptidyl-threonine phosphorylation

physically interacts with

sotrastaurin

object of statement has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL565612

gsk-690693

object of statement has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL494089

has part(s)

diacylglycerol/phorbol-ester binding

1 reference

protein kinase C-like, phorbol ester/diacylglycerol-binding domain

1 reference

protein kinase, ATP binding site

1 reference

pleckstrin homology domain

1 reference

protein kinase domain

1 reference

serine/threonine-protein kinase, active site

1 reference