(Q21116456)

1 reference

9 May 2019

NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

interleukin-6 receptor binding

1 reference

9 May 2019

Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

BMP receptor binding

1 reference

9 May 2019

Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

protein binding

23 references

9 May 2019

PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

9 May 2019

Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

9 May 2019

The PYRIN domain-only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

9 May 2019

Cellular pyrin domain-only protein 2 is a candidate regulator of inflammasome activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

9 May 2019

Overexpressed NLRC3 acts as an anti-inflammatory cytosolic protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

9 May 2019

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

9 May 2019

Syk is involved in NLRP3 inflammasome-mediated caspase-1 activation through adaptor ASC phosphorylation and enhanced oligomerization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

9 May 2019

ASC is a Bax adaptor and regulates the p53-Bax mitochondrial apoptosis pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

9 May 2019

PYPAF1, a PYRIN-containing Apaf1-like protein that assembles with ASC and regulates activation of NF-kappa B

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

9 May 2019

Interaction between pyrin and the apoptotic speck protein (ASC) modulates ASC-induced apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

9 May 2019

Cryopyrin-induced interleukin 1beta secretion in monocytic cells: enhanced activity of disease-associated mutants and requirement for ASC

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

9 May 2019

A proteome-scale map of the human interactome network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

9 May 2019

Identification of multifaceted binding modes for pyrin and ASC pyrin domains gives insights into pyrin inflammasome assembly

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

9 May 2019

Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

9 May 2019

Human cytomegalovirus tegument protein pUL83 inhibits IFI16-mediated DNA sensing for immune evasion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

9 May 2019

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

9 May 2019

Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

9 May 2019

Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

9 May 2019

Pyrin activates the ASC pyroptosome in response to engagement by autoinflammatory PSTPIP1 mutants

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

9 May 2019

In silico prediction of physical protein interactions and characterization of interactome orphans

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

9 May 2019

The PAAD/PYRIN-only protein POP1/ASC2 is a modulator of ASC-mediated nuclear-factor-kappa B and pro-caspase-1 regulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

9 May 2019

NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

9 May 2019

Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

identical protein binding

3 references

9 May 2019

Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

9 May 2019

A proteome-scale map of the human interactome network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

9 May 2019

Identification of multifaceted binding modes for pyrin and ASC pyrin domains gives insights into pyrin inflammasome assembly

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

enzyme binding

1 reference

9 May 2019

Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

cysteine-type endopeptidase activity involved in apoptotic process

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

Pyrin domain binding

1 reference

9 May 2019

NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

cysteine-type endopeptidase activator activity involved in apoptotic process

1 reference

9 May 2019

PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

myosin I binding

1 reference

9 May 2019

Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

tropomyosin binding

1 reference

9 May 2019

Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

protease binding

1 reference

27 March 2018

Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9ULZ3&geneProductId=UniProtKB:Q9ULZ3

transmembrane transporter binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

cysteine-type endopeptidase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

1 reference

9 May 2019

cell component

cytoplasm

PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing

5 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9ULZ3&geneProductId=UniProtKB:Q9ULZ3

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9ULZ3&geneProductId=UniProtKB:Q9ULZ3

27 March 2018

27 March 2018

ASC is a Bax adaptor and regulates the p53-Bax mitochondrial apoptosis pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9ULZ3&geneProductId=UniProtKB:Q9ULZ3

27 March 2018

An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9ULZ3&geneProductId=UniProtKB:Q9ULZ3

27 March 2018

NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9ULZ3&geneProductId=UniProtKB:Q9ULZ3

NLRP3 inflammasome complex

1 reference

9 May 2019

NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

NLRP1 inflammasome complex

1 reference

9 May 2019

The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

AIM2 inflammasome complex

1 reference

9 May 2019

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

nucleolus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

1 reference

9 May 2019

endoplasmic reticulum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

1 reference

9 May 2019

IkappaB kinase complex

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

9 May 2019

secretory granule lumen

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

1 reference

9 May 2019

azurophil granule lumen

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

1 reference

9 May 2019

extracellular region

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9ULZ3&geneProductId=UniProtKB:Q9ULZ3

1 reference

27 March 2018

cytoplasm

PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing

6 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

9 May 2019

9 May 2019

ASC is a Bax adaptor and regulates the p53-Bax mitochondrial apoptosis pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

9 May 2019

An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

9 May 2019

NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

cytosol

protein-containing complex

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

soma

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

Golgi membrane

1 reference

14 January 2019

Human respiratory syncytial virus viroporin SH: a viral recognition pathway used by the host to signal inflammasome activation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9ULZ3&geneProductId=UniProtKB:Q9ULZ3

Golgi apparatus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

1 reference

9 May 2019

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

1 reference

9 May 2019

positive regulation of cysteine-type endopeptidase activity

biological process

1 reference

9 May 2019

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

1 reference

9 May 2019

ASC is a Bax adaptor and regulates the p53-Bax mitochondrial apoptosis pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

regulation of intrinsic apoptotic signaling pathway

1 reference

9 May 2019

ASC is a Bax adaptor and regulates the p53-Bax mitochondrial apoptosis pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

intrinsic apoptotic signaling pathway by p53 class mediator

1 reference

9 May 2019

ASC is a Bax adaptor and regulates the p53-Bax mitochondrial apoptosis pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

positive regulation of adaptive immune response

1 reference

9 May 2019

Central and overlapping role of Cathepsin B and inflammasome adaptor ASC in antigen presenting function of human dendritic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

defense response to Gram-negative bacterium

2 references

9 May 2019

The NLR adaptor ASC/PYCARD regulates DUSP10, mitogen-activated protein kinase (MAPK), and chemokine induction independent of the inflammasome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

9 May 2019

Cutting edge: ASC mediates the induction of multiple cytokines by Porphyromonas gingivalis via caspase-1-dependent and -independent pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

immune system process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

1 reference

9 May 2019

cellular response to tumor necrosis factor

1 reference

9 May 2019

The PAAD/PYRIN-family protein ASC is a dual regulator of a conserved step in nuclear factor kappaB activation pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

regulation of tumor necrosis factor-mediated signaling pathway

1 reference

9 May 2019

ASC is a Bax adaptor and regulates the p53-Bax mitochondrial apoptosis pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

positive regulation of DNA-binding transcription factor activity

1 reference

9 May 2019

Mechanism and repertoire of ASC-mediated gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

tumor necrosis factor-mediated signaling pathway

1 reference

9 May 2019

The PAAD/PYRIN-only protein POP1/ASC2 is a modulator of ASC-mediated nuclear-factor-kappa B and pro-caspase-1 regulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

positive regulation of JNK cascade

1 reference

9 May 2019

The NLR adaptor ASC/PYCARD regulates DUSP10, mitogen-activated protein kinase (MAPK), and chemokine induction independent of the inflammasome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

negative regulation of interferon-beta production

1 reference

9 May 2019

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

negative regulation of I-kappaB kinase/NF-kappaB signaling

1 reference

9 May 2019

The PAAD/PYRIN-family protein ASC is a dual regulator of a conserved step in nuclear factor kappaB activation pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

myeloid dendritic cell activation

1 reference

9 May 2019

Central and overlapping role of Cathepsin B and inflammasome adaptor ASC in antigen presenting function of human dendritic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

positive regulation of T cell activation

1 reference

9 May 2019

Central and overlapping role of Cathepsin B and inflammasome adaptor ASC in antigen presenting function of human dendritic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

defense response to virus

1 reference

9 May 2019

IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

cellular response to interleukin-1

1 reference

9 May 2019

The PAAD/PYRIN-family protein ASC is a dual regulator of a conserved step in nuclear factor kappaB activation pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

positive regulation of apoptotic process

1 reference

9 May 2019

ASC is an activating adaptor for NF-kappa B and caspase-8-dependent apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

positive regulation of tumor necrosis factor production

2 references

9 May 2019

The NLR adaptor ASC/PYCARD regulates DUSP10, mitogen-activated protein kinase (MAPK), and chemokine induction independent of the inflammasome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

9 May 2019

Cutting edge: ASC mediates the induction of multiple cytokines by Porphyromonas gingivalis via caspase-1-dependent and -independent pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

positive regulation of release of cytochrome c from mitochondria

1 reference

9 May 2019

ASC is a Bax adaptor and regulates the p53-Bax mitochondrial apoptosis pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

negative regulation of protein serine/threonine kinase activity

1 reference

9 May 2019

The PAAD/PYRIN-family protein ASC is a dual regulator of a conserved step in nuclear factor kappaB activation pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

positive regulation of extrinsic apoptotic signaling pathway

1 reference

9 May 2019

Mechanism of ASC-mediated apoptosis: bid-dependent apoptosis in type II cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

inflammatory response

cellular response to lipopolysaccharide

1 reference

9 May 2019

The PAAD/PYRIN-family protein ASC is a dual regulator of a conserved step in nuclear factor kappaB activation pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

negative regulation of NF-kappaB transcription factor activity

1 reference

9 May 2019

ASC directs NF-kappaB activation by regulating receptor interacting protein-2 (RIP2) caspase-1 interactions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

signal transduction

1 reference

9 May 2019

PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

neutrophil degranulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

1 reference

9 May 2019

positive regulation of NF-kappaB transcription factor activity

PYPAF3, a PYRIN-containing APAF-1-like protein, is a feedback regulator of caspase-1-dependent interleukin-1beta secretion

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

9 May 2019

ASC is an activating adaptor for NF-kappa B and caspase-8-dependent apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

9 May 2019

The PAAD/PYRIN-only protein POP1/ASC2 is a modulator of ASC-mediated nuclear-factor-kappa B and pro-caspase-1 regulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

activation of innate immune response

1 reference

27 March 2018

IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9ULZ3&geneProductId=UniProtKB:Q9ULZ3

myeloid dendritic cell activation involved in immune response

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9ULZ3&geneProductId=UniProtKB:Q9ULZ3

1 reference

27 March 2018

positive regulation of antigen processing and presentation of peptide antigen via MHC class II

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9ULZ3&geneProductId=UniProtKB:Q9ULZ3

1 reference

27 March 2018

activation of cysteine-type endopeptidase activity involved in apoptotic process

1 reference

27 March 2018

PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9ULZ3&geneProductId=UniProtKB:Q9ULZ3

positive regulation of actin filament polymerization

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9ULZ3&geneProductId=UniProtKB:Q9ULZ3

1 reference

27 March 2018

regulation of protein stability

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9ULZ3&geneProductId=UniProtKB:Q9ULZ3

1 reference

27 March 2018

positive regulation of interferon-gamma production

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9ULZ3&geneProductId=UniProtKB:Q9ULZ3

1 reference

27 March 2018

positive regulation of interleukin-6 production

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9ULZ3&geneProductId=UniProtKB:Q9ULZ3

1 reference

27 March 2018

positive regulation of activated T cell proliferation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9ULZ3&geneProductId=UniProtKB:Q9ULZ3

1 reference

27 March 2018

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

1 reference

27 March 2018

NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9ULZ3&geneProductId=UniProtKB:Q9ULZ3

macropinocytosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9ULZ3&geneProductId=UniProtKB:Q9ULZ3

1 reference

27 March 2018

positive regulation of phagocytosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9ULZ3&geneProductId=UniProtKB:Q9ULZ3

1 reference

27 March 2018

positive regulation of ERK1 and ERK2 cascade

1 reference

27 March 2018

The NLR adaptor ASC/PYCARD regulates DUSP10, mitogen-activated protein kinase (MAPK), and chemokine induction independent of the inflammasome

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9ULZ3&geneProductId=UniProtKB:Q9ULZ3

positive regulation of T cell migration

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9ULZ3&geneProductId=UniProtKB:Q9ULZ3

1 reference

27 March 2018

positive regulation of defense response to virus by host

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

apoptotic process

ASC, a novel 22-kDa protein, aggregates during apoptosis of human promyelocytic leukemia HL-60 cells

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

9 May 2019

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

activation of cysteine-type endopeptidase activity involved in apoptotic process

intrinsic apoptotic signaling pathway in response to DNA damage

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

response to bacterium

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

regulation of autophagy

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

interleukin-1 beta production

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

regulation of GTPase activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

regulation of cysteine-type endopeptidase activity involved in apoptotic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

regulation of inflammatory response

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

protein homooligomerization

1 reference

9 May 2019

The PYRIN domain-only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

activation of cysteine-type endopeptidase activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

negative regulation of cytokine production involved in inflammatory response

1 reference

9 May 2019

The PYRIN domain-only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

proteolysis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

1 reference

9 May 2019

positive regulation of interleukin-1 beta production

1 reference

9 May 2019

Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

9 May 2019

NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016