(Q21112952)

English

Caspase recruitment domain family member 8

mammalian protein found in Homo sapiens

DACAR
CARD8
tumor up-regulated CARD-containing antagonist of CASP9
CARDINAL
apoptotic protein NDPP1
TUCAN
caspase recruitment domain-containing protein 8
CARD inhibitor of NF-kappaB-activating ligands
CARD-inhibitor of NF-kappa-B-activating ligand
tumor up-regulated CARD-containing antagonist of caspase nine

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Statements

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

13 November 2019

cysteine-type endopeptidase activator activity involved in apoptotic process

determination method or standard

IDA

1 reference

retrieved

5 June 2018

stated in

NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder

GOA

curator

HUGO Gene Nomenclature Committee

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y2G2&geneProductId=UniProtKB:Q9Y2G2

determination method or standard

IDA

protein binding

determination method or standard

IPI

protein homodimerization activity

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder

GOA

curator

HUGO Gene Nomenclature Committee

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2G2

determination method or standard

IDA

NACHT domain binding

determination method or standard

IPI

1 reference

retrieved

8 April 2019

stated in

NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder

GOA

curator

HUGO Gene Nomenclature Committee

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2G2

determination method or standard

IPI

CARD domain binding

determination method or standard

IPI

1 reference

retrieved

8 April 2019

stated in

CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2G2

determination method or standard

IPI

identical protein binding

determination method or standard

IPI

1 reference

retrieved

5 June 2018

stated in

TUCAN/CARDINAL and DRAL participate in a common pathway for modulation of NF-kappaB activation.

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y2G2&geneProductId=UniProtKB:Q9Y2G2

determination method or standard

IPI

cysteine-type endopeptidase activator activity involved in apoptotic process

determination method or standard

IBA

IDA

cell component

NLRP3 inflammasome complex

determination method or standard

IDA

1 reference

retrieved

5 June 2018

stated in

NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y2G2&geneProductId=UniProtKB:Q9Y2G2

determination method or standard

IDA

nucleoplasm

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2G2

determination method or standard

IDA

cytosol

determination method or standard

1 reference

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y2G2&geneProductId=UniProtKB:Q9Y2G2

determination method or standard

IDA

protein-containing complex

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2G2

determination method or standard

IDA

inflammasome complex

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2G2

determination method or standard

IBA

NLRP3 inflammasome complex

determination method or standard

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2G2

determination method or standard

IEA

regulation of apoptotic process

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2G2

determination method or standard

IEA

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

determination method or standard

IDA

negative regulation of I-kappaB kinase/NF-kappaB signaling

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

CARDINAL, a novel caspase recruitment domain protein, is an inhibitor of multiple NF-kappa B activation pathways

GOA

curator

HUGO Gene Nomenclature Committee

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2G2

determination method or standard

IDA

activation of cysteine-type endopeptidase activity involved in apoptotic process

determination method or standard

1 reference

5 June 2018

Gene Ontology Consortium

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y2G2&geneProductId=UniProtKB:Q9Y2G2

determination method or standard

IEA

negative regulation of tumor necrosis factor-mediated signaling pathway

determination method or standard

IMP

1 reference

retrieved

8 April 2019

stated in

CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2G2

determination method or standard

IMP

negative regulation of lipopolysaccharide-mediated signaling pathway

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2G2

determination method or standard

IDA

negative regulation of NF-kappaB transcription factor activity

determination method or standard

IMP

1 reference

retrieved

8 April 2019

stated in

CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2G2

determination method or standard

IMP

inhibition of cysteine-type endopeptidase activity

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2G2

determination method or standard

IDA

activation of cysteine-type endopeptidase activity involved in apoptotic process

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2G2

determination method or standard

IBA

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

determination method or standard

3 references

8 April 2019

CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2G2

determination method or standard

IDA

retrieved

8 April 2019

stated in

NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder

GOA

curator

HUGO Gene Nomenclature Committee

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2G2

determination method or standard

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2G2

determination method or standard

IBA

Identifiers

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30 May 2020

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30 June 2016

language of work or name

English

(Q21112952)

Caspase recruitment domain family member 8

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