Wikidata

(Q21097479)

English

Embryonic ectoderm development

mammalian protein found in Homo sapiens

  • polycomb protein EED
  • EED
  • embryonic ectoderm development protein
  • WD protein associating with integrin cytoplasmic tails 1
  • WAIT-1
In more languages
default for all languages
No label defined

No description defined

Statements

molecular function
protein binding
determination method or standard
IPI
16 references
retrieved
8 April 2019
stated in
Mutations in genes encoding polycomb repressive complex 2 subunits cause Weaver syndrome
GOA
curator
UniProt
UniProt protein ID
O75530
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75530
determination method or standard
IPI
retrieved
8 April 2019
stated in
Corepressor protein CDYL functions as a molecular bridge between polycomb repressor complex 2 and repressive chromatin mark trimethylated histone lysine 27
GOA
curator
UniProt
UniProt protein ID
O75530
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75530
determination method or standard
IPI
retrieved
8 April 2019
stated in
Role of the polycomb repressive complex 2 in acute promyelocytic leukemia
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75530
determination method or standard
IPI
retrieved
8 April 2019
stated in
Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75530
determination method or standard
IPI
retrieved
8 April 2019
stated in
CRL4B catalyzes H2AK119 monoubiquitination and coordinates with PRC2 to promote tumorigenesis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75530
determination method or standard
IPI
retrieved
8 April 2019
stated in
Deconstruction of the SS18-SSX fusion oncoprotein complex: insights into disease etiology and therapeutics
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75530
determination method or standard
IPI
retrieved
8 April 2019
stated in
Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to promoter CpG Islands
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75530
determination method or standard
IPI
retrieved
8 April 2019
stated in
The Polycomb group protein EZH2 directly controls DNA methylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75530
determination method or standard
IPI
retrieved
8 April 2019
stated in
CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75530
determination method or standard
IPI
retrieved
8 April 2019
stated in
ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75530
determination method or standard
IPI
retrieved
8 April 2019
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75530
determination method or standard
IPI
retrieved
8 April 2019
stated in
A High-Density Map for Navigating the Human Polycomb Complexome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75530
determination method or standard
IPI
retrieved
8 April 2019
stated in
The Polycomb group protein EED couples TNF receptor 1 to neutral sphingomyelinase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75530
determination method or standard
IPI
retrieved
8 April 2019
stated in
JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75530
determination method or standard
IPI
retrieved
8 April 2019
stated in
Role for the MOV10 RNA helicase in polycomb-mediated repression of the INK4a tumor suppressor.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75530
determination method or standard
IPI
retrieved
8 April 2019
stated in
Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75530
determination method or standard
IPI
cell component
ESC/E(Z) complex
determination method or standard
IDA
IEA
6 references
retrieved
27 February 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O75530&geneProductId=UniProtKB:O75530
determination method or standard
IEA
retrieved
27 February 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O75530&geneProductId=UniProtKB:O75530
determination method or standard
IEA
retrieved
27 February 2018
stated in
Phf19 links methylated Lys36 of histone H3 to regulation of Polycomb activity
GOA
curator
UniProt
UniProt protein ID
O75530
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O75530&geneProductId=UniProtKB:O75530
determination method or standard
IDA
retrieved
27 February 2018
stated in
An H3K36 methylation-engaging Tudor motif of polycomb-like proteins mediates PRC2 complex targeting
GOA
curator
UniProt
UniProt protein ID
O75530
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O75530&geneProductId=UniProtKB:O75530
determination method or standard
IDA
retrieved
27 February 2018
stated in
JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells
GOA
curator
UniProt
UniProt protein ID
O75530
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O75530&geneProductId=UniProtKB:O75530
determination method or standard
IDA
retrieved
27 February 2018
stated in
Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O75530&geneProductId=UniProtKB:O75530
determination method or standard
IDA
ESC/E(Z) complex
determination method or standard
IBA
IDA
IEA
7 references
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75530
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75530
determination method or standard
IEA
retrieved
8 April 2019
stated in
JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells
GOA
curator
UniProt
UniProt protein ID
O75530
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75530
determination method or standard
IDA
retrieved
8 April 2019
stated in
An H3K36 methylation-engaging Tudor motif of polycomb-like proteins mediates PRC2 complex targeting
GOA
curator
UniProt
UniProt protein ID
O75530
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75530
determination method or standard
IDA
retrieved
8 April 2019
stated in
Phf19 links methylated Lys36 of histone H3 to regulation of Polycomb activity
GOA
curator
UniProt
UniProt protein ID
O75530
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75530
determination method or standard
IDA
retrieved
8 April 2019
stated in
Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75530
determination method or standard
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75530
determination method or standard
IBA
biological process

Identifiers

PDB structure ID
 
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