(Q21034080)

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Review of the clinical pharmacokinetics of artesunate and its active metabolite dihydroartemisinin following intravenous, intramuscular, oral or rectal administration

scientific article published on 13 September 2011

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22 June 2019

4 November 2019

7 November 2019

28 May 2020

18 July 2021

Review of the clinical pharmacokinetics of artesunate and its active metabolite dihydroartemisinin following intravenous, intramuscular, oral or rectal administration (English)

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infectious disease

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inorganic compound

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4 November 2019

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7 November 2019

pharmacokinetics

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based on heuristic

inferred from title

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18 July 2021

Lawrence Fleckenstein

6

object named as

Lawrence Fleckenstein

author given names

Lawrence

author last names

Fleckenstein

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PubMed publication ID

27 July 2022

author name string

Carrie A Morris

1

author given names

Carrie A

author last names

Morris

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PubMed publication ID

27 July 2022

Stephan Duparc

2

author given names

Stephan

author last names

Duparc

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PubMed publication ID

27 July 2022

Isabelle Borghini-Fuhrer

3

author given names

Isabelle

author last names

Borghini-Fuhrer

1 reference

PubMed publication ID

27 July 2022

Donald Jung

4

author given names

Donald

author last names

Jung

1 reference

PubMed publication ID

27 July 2022

Chang-Sik Shin

5

author given names

Chang-Sik

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Shin

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PubMed publication ID

27 July 2022

language of work or name

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publication date

13 September 2011

5 references

22 June 2019

4 November 2019

7 November 2019

28 May 2020

18 July 2021

Malaria Journal

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22 June 2019

4 November 2019

7 November 2019

28 May 2020

18 July 2021

10

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1

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263

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copyright license

Creative Commons Attribution 2.0 Generic

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Europe PubMed Central

22 June 2019

Europe PubMed Central

4 November 2019

Europe PubMed Central

7 November 2019

Europe PubMed Central

28 May 2020

Europe PubMed Central

18 July 2021

copyright status

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on focus list of Wikimedia project

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New Fixed-Dose Artesunate-Mefloquine Formulation against Multidrug-Resistant Plasmodium falciparum in Adults: a Comparative Phase IIb Safety and Pharmacokinetic Study with Standard-Dose Nonfixed Artesunate plus Mefloquine

1 reference

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19 March 2017

Pharmacokinetics of artesunate after single oral administration to rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3180444

19 March 2017

Artemisinin Resistance in Plasmodium falciparum Malaria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3180444

19 March 2017

Population pharmacokinetics of artesunate and dihydroartemisinin following intra-rectal dosing of artesunate in malaria patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3180444

19 March 2017

Multiple dose study of interactions between artesunate and artemisinin in healthy volunteers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3180444

19 March 2017

Oral bioavailability of dihydroartemisinin in Vietnamese volunteers and in patients with falciparum malaria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3180444

19 March 2017

Population pharmacokinetics of artesunate and dihydroartemisinin in pregnant and non-pregnant women with malaria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3180444

12 September 2017

Pharmacokinetics and pharmacodynamics of artesunate and dihydroartemisinin following oral treatment in pregnant women with asymptomatic Plasmodium falciparum infections in Kinshasa DRC.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3180444

12 September 2017

Intravenous artesunate for the treatment of severe malaria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3180444

12 September 2017

Pharmacokinetics and pharmacodynamics of a new ACT formulation: Artesunate/Amodiaquine (TRIMALACT) following oral administration in African malaria patients.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3180444

12 September 2017

Population pharmacokinetics of artesunate and dihydroartemisinin following single- and multiple-dosing of oral artesunate in healthy subjects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3180444

12 September 2017

Pharmacokinetics of artemether-lumefantrine and artesunate-amodiaquine in children in Kampala, Uganda

1 reference

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12 September 2017

Population pharmacokinetics of artesunate and amodiaquine in African children

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3180444

12 September 2017

Pharmacokinetics, tissue distribution and mass balance of radiolabeled dihydroartemisinin in male rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3180444

12 September 2017

Pharmacokinetics and pharmacodynamics of endoperoxide antimalarials

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3180444

12 September 2017

Tolerability and pharmacokinetics of non-fixed and fixed combinations of artesunate and amodiaquine in Malaysian healthy normal volunteers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3180444

12 September 2017

Major pitfalls in the measurement of artemisinin derivatives in plasma in clinical studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3180444

12 September 2017

Pharmacokinetics and tolerability of artesunate and amodiaquine alone and in combination in healthy volunteers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3180444

12 September 2017

Pharmacokinetics of oral artesunate in thai patients with uncomplicated falciparum malaria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3180444

12 September 2017

Comparative study of the effectiveness and pharmacokinetics of two rectal artesunate/oral mefloquine combination regimens for the treatment of uncomplicated childhood falciparum malaria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3180444

12 September 2017

The pharmacokinetics of intravenous artesunate in adults with severe falciparum malaria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3180444

12 September 2017

Comparative pharmacokinetics of intramuscular artesunate and artemether in patients with severe falciparum malaria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3180444

12 September 2017

Disposition of artesunate and dihydroartemisinin after administration of artesunate suppositories in children from Papua New Guinea with uncomplicated malaria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3180444

12 September 2017

Protein binding and alpha : beta anomer ratio of dihydroartemisinin in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3180444

12 September 2017

Intramuscular bioavailability and clinical efficacy of artesunate in gabonese children with severe malaria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3180444

12 September 2017

Comparison of oral artesunate and dihydroartemisinin antimalarial bioavailabilities in acute falciparum malaria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3180444

12 September 2017

The pharmacokinetic properties of intramuscular artesunate and rectal dihydroartemisinin in uncomplicated falciparum malaria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3180444

12 September 2017

Bioavailability and preliminary clinical efficacy of intrarectal artesunate in Ghanaian children with moderate malaria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3180444

12 September 2017

Pharmacokinetics and pharmacodynamics of intravenous artesunate in severe falciparum malaria.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3180444

12 September 2017

Antimalarial bioavailability and disposition of artesunate in acute falciparum malaria

1 reference

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12 September 2017

Effects of alpha-thalassemia on pharmacokinetics of the antimalarial agent artesunate.

1 reference

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12 September 2017

A pharmacokinetic and pharmacodynamic study of intravenous vs oral artesunate in uncomplicated falciparum malaria.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3180444

12 September 2017

Pharmacokinetics of oral artesunate in children with moderately severe Plasmodium falciparum malaria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3180444

12 September 2017

Assessment of the effect of mefloquine on artesunate pharmacokinetics in healthy male volunteers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3180444

30 May 2018

Pharmacokinetics of artesunate following oral and rectal administration in healthy Sudanese volunteers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3180444

30 May 2018

Comparative pharmacokinetic study of oral and rectal formulations of artesunic acid in healthy volunteers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3180444

30 May 2018

Pharmacokinetic profiles of artesunate after single intravenous doses at 0.5, 1, 2, 4, and 8 mg/kg in healthy volunteers: a phase I study

1 reference

https://api.crossref.org/works/10.1186/1475-2875-10-263

21 January 2018

Glucuronidation of dihydroartemisinin in vivo and by human liver microsomes and expressed UDP-glucuronosyltransferases

1 reference

https://api.crossref.org/works/10.1186/1475-2875-10-263

21 January 2018

Pharmacokinetic and bioequivalence evaluation of two generic formulations of oral artesunate

1 reference

https://api.crossref.org/works/10.1186/1475-2875-10-263

21 January 2018

Absence of time-dependent artesunate pharmacokinetics in healthy subjects during 5-day oral administration

1 reference

https://api.crossref.org/works/10.1186/1475-2875-10-263

21 January 2018

Pharmacokinetics of chlorproguanil, dapsone, artesunate and their major metabolites in patients during treatment of acute uncomplicated Plasmodium falciparum malaria.

1 reference

https://api.crossref.org/works/10.1186/1475-2875-10-263

21 January 2018

Fixed-dose pyronaridine-artesunate combination for treatment of uncomplicated falciparum malaria in pediatric patients in Gabon

1 reference

https://api.crossref.org/works/10.1186/1475-2875-10-263

21 January 2018

Pharmacokinetics of two paediatric artesunate mefloquine drug formulations in the treatment of uncomplicated falciparum malaria in Gabon

1 reference

https://api.crossref.org/works/10.1186/1475-2875-10-263

21 January 2018

Pharmacokinetics of dihydroartemisinin following oral artesunate treatment of pregnant women with acute uncomplicated falciparum malaria

1 reference

https://api.crossref.org/works/10.1186/1475-2875-10-263

21 January 2018

Absence of an interaction between artesunate and atovaquone--proguanil

1 reference

https://api.crossref.org/works/10.1186/1475-2875-10-263

21 January 2018

Lack of impact of artesunate on the disposition kinetics of sulfadoxine/pyrimethamine when the two drugs are concomitantly administered

1 reference

https://api.crossref.org/works/10.1186/1475-2875-10-263

21 January 2018

The evaluation of radiolabeled artesunate on tissue distribution in rats and protein binding in humans.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3180444

29 November 2018

Investigation of bioavailability, pharmacokinetics and safety of new pediatric formulations of artesunate and mefloquine.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3180444

29 November 2018

The pharmacokinetics of oral dihydroartemisinin and artesunate in healthy Thai volunteers.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3180444

29 November 2018

Relative bioavailability of artesunate and dihydroartemisinin: investigations in the isolated perfused rat liver and in healthy Caucasian volunteers.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3180444

29 November 2018

Comparative pharmacokinetics and effect kinetics of orally administered artesunate in healthy volunteers and patients with uncomplicated falciparum malaria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3180444

29 November 2018

A pharmacokinetic and pharmacodynamic study of artesunate for vivax malaria.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3180444

29 November 2018

Plasma levels of artesunate and dihydroartemisinin in children with Plasmodium falciparum malaria in Gabon after administration of 50-milligram artesunate suppositories

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3180444

29 November 2018

Pharmacokinetics of artemisinin and artesunate after oral administration in healthy volunteers.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3180444

29 November 2018

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10.1186/1475-2875-10-263

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Consolidated OpenCitations Corpus – April 2017

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Dimensions Publication ID

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9 September 2019

https://scigraph.springernature.com/pub.10.1186/1475-2875-10-263

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PMC publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PubMed publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

ResearchGate publication ID

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