(Q14903156)

Cystine-knot cytokine

1 reference

Transforming growth factor-beta, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

TGF-beta, propeptide family

1 reference

based on heuristic

inferred from protein domain or family

Transforming growth factor beta, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

transforming growth factor beta receptor binding

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

BMP receptor binding

A mammalian serine/threonine kinase receptor specifically binds BMP-2 and BMP-4

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

protein binding

8 references

8 April 2019

WISP-1/CCN4 regulates osteogenesis by enhancing BMP-2 activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

PLAP-1/asporin, a novel negative regulator of periodontal ligament mineralization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

Microfibril-associated glycoprotein 2 (MAGP2) loss of function has pleiotropic effects in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

Cartilage oligomeric matrix protein inhibits vascular smooth muscle calcification by interacting with bone morphogenetic protein-2.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

A novel chordin-like BMP inhibitor, CHL2, expressed preferentially in chondrocytes of developing cartilage and osteoarthritic joint cartilage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

The NH2-terminal propeptide of type I procollagen acts intracellularly to modulate cell function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

BMPER, a novel endothelial cell precursor-derived protein, antagonizes bone morphogenetic protein signaling and endothelial cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

NAD-retinol dehydrogenase activity

1 reference

8 April 2019

RDH10 is essential for synthesis of embryonic retinoic acid and is required for limb, craniofacial, and organ development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

signaling receptor binding

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21274&geneProductId=UniProtKB:P21274

growth factor activity

protein domain specific binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

protein homodimerization activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

cytokine activity

Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

cell component

extracellular region

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

1 reference

8 April 2019

extracellular space

4 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21274&geneProductId=UniProtKB:P21274

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21274&geneProductId=UniProtKB:P21274

24 April 2018

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21274&geneProductId=UniProtKB:P21274

24 April 2018

Bone morphogenetic protein-2 can mediate myocardial regulation of atrioventricular cushion mesenchymal cell formation in mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21274&geneProductId=UniProtKB:P21274

cytoplasm

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

vesicle

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

protein-containing complex

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

extracellular space

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

Bone morphogenetic protein-2 can mediate myocardial regulation of atrioventricular cushion mesenchymal cell formation in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

positive regulation of Wnt signaling pathway by BMP signaling pathway

biological process

1 reference

8 April 2019

Wnt11 promotes osteoblast maturation and mineralization through R-spondin 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

mesenchyme development

ISS

odontogenesis of dentin-containing tooth

1 reference

8 April 2019

Follistatin regulates enamel patterning in mouse incisors by asymmetrically inhibiting BMP signaling and ameloblast differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

telencephalon regionalization

1 reference

8 April 2019

Patterning of the dorsal telencephalon and cerebral cortex by a roof plate-Lhx2 pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

atrioventricular valve morphogenesis

1 reference

8 April 2019

Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

proteoglycan metabolic process

1 reference

8 April 2019

Indian and sonic hedgehogs regulate synchondrosis growth plate and cranial base development and function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

mesenchymal cell differentiation

ISS

pericardium development

1 reference

8 April 2019

Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

positive regulation of ERK1 and ERK2 cascade

ISS

animal organ morphogenesis

1 reference

8 April 2019

Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

inner ear development

1 reference

8 April 2019

Developmental profiling of spiral ganglion neurons reveals insights into auditory circuit assembly.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

transforming growth factor beta receptor signaling pathway

TAS

1 reference

8 April 2019

Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

negative regulation of canonical Wnt signaling pathway

TAS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

negative regulation of cell population proliferation

Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

Glypican-3 modulates inhibitory Bmp2-Smad signaling to control renal development in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

regulation of apoptotic process

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

cell fate commitment

1 reference

8 April 2019

Bone morphogenetic protein 2/4 signaling regulates early thymocyte differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

regulation of MAPK cascade

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

SMAD protein signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

4 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

ossification

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

1 reference

8 April 2019

cardiac muscle cell differentiation

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

Bmp signaling regulates myocardial differentiation from cardiac progenitors through a MicroRNA-mediated mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

in utero embryonic development

1 reference

8 April 2019

Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

mesenchymal cell proliferation involved in ureteric bud development

1 reference

8 April 2019

Glypican-3 modulates inhibitory Bmp2-Smad signaling to control renal development in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

regulation of odontogenesis of dentin-containing tooth

1 reference

8 April 2019

Antagonistic Interactions between FGF and BMP Signaling Pathways: A Mechanism for Positioning the Sites of Tooth Formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

positive regulation of Wnt signaling pathway

1 reference

8 April 2019

Murine Frizzled-1 behaves as an antagonist of the canonical Wnt/beta-catenin signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

heart development

1 reference

8 April 2019

Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

branching involved in ureteric bud morphogenesis

1 reference

8 April 2019

Glypican-3 modulates inhibitory Bmp2-Smad signaling to control renal development in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

cartilage development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

1 reference

8 April 2019

positive regulation of cartilage development

Novel regulators of bone formation: molecular clones and activities

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

Regulation of skeletal progenitor differentiation by the BMP and retinoid signaling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

positive regulation of neuron differentiation

1 reference

8 April 2019

Neuronal differentiation of precursors in the neocortical ventricular zone is triggered by BMP

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

positive regulation of cell differentiation

1 reference

8 April 2019

Follistatin regulates enamel patterning in mouse incisors by asymmetrically inhibiting BMP signaling and ameloblast differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

thyroid-stimulating hormone-secreting cell differentiation

1 reference

8 April 2019

Integrated FGF and BMP signaling controls the progression of progenitor cell differentiation and the emergence of pattern in the embryonic anterior pituitary

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

inflammatory response

1 reference

8 April 2019

Activation of bone morphogenetic protein/Smad signaling in bronchial epithelial cells during airway inflammation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

positive regulation of fat cell differentiation

1 reference

8 April 2019

Reciprocal roles of MSX2 in regulation of osteoblast and adipocyte differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

positive regulation of pri-miRNA transcription by RNA polymerase II

1 reference

8 April 2019

Bmp signaling regulates myocardial differentiation from cardiac progenitors through a MicroRNA-mediated mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

Notch signaling pathway

1 reference

8 April 2019

Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

bone mineralization

Wnt11 promotes osteoblast maturation and mineralization through R-spondin 2

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

TIEG1 null mouse-derived osteoblasts are defective in mineralization and in support of osteoclast differentiation in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

Wnt11 promotes osteoblast maturation and mineralization through R-spondin 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

1 reference

8 April 2019

corticotropin hormone secreting cell differentiation

1 reference

8 April 2019

Integrated FGF and BMP signaling controls the progression of progenitor cell differentiation and the emergence of pattern in the embryonic anterior pituitary

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

positive regulation of astrocyte differentiation

Id4 is required for the correct timing of neural differentiation

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

Astrocyte differentiation mediated by LIF in cooperation with BMP2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

Id4 is required for the correct timing of neural differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

cellular response to organic cyclic compound

1 reference

8 April 2019

Inhibition of microtubule assembly in osteoblasts stimulates bone morphogenetic protein 2 expression and bone formation through transcription factor Gli2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

positive regulation of ossification

Effect of rhBMP-2 on the osteogenic potential of bone marrow stromal cells from an osteogenesis imperfecta mouse (oim)

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

A Runx2/miR-3960/miR-2861 regulatory feedback loop during mouse osteoblast differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

negative regulation of transcription by RNA polymerase II

Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development

4 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21274&geneProductId=UniProtKB:P21274

24 April 2018

Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21274&geneProductId=UniProtKB:P21274

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21274&geneProductId=UniProtKB:P21274

24 April 2018

Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21274&geneProductId=UniProtKB:P21274

positive regulation of epithelial to mesenchymal transition

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

BMP signaling pathway

Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4

8 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21274&geneProductId=UniProtKB:P21274

24 April 2018

Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21274&geneProductId=UniProtKB:P21274

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21274&geneProductId=UniProtKB:P21274

24 April 2018

C-terminal domain (CTD) small phosphatase-like 2 modulates the canonical bone morphogenetic protein (BMP) signaling and mesenchymal differentiation via Smad dephosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21274&geneProductId=UniProtKB:P21274

24 April 2018

Neogenin inhibits HJV secretion and regulates BMP-induced hepcidin expression and iron homeostasis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21274&geneProductId=UniProtKB:P21274

24 April 2018

A novel neural-specific BMP antagonist, Brorin-like, of the Chordin family

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21274&geneProductId=UniProtKB:P21274

24 April 2018

Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21274&geneProductId=UniProtKB:P21274

24 April 2018

Akt promotes BMP2-mediated osteoblast differentiation and bone development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21274&geneProductId=UniProtKB:P21274

positive regulation of neurogenesis

1 reference

8 April 2019

Alternative neural crest cell fates are instructively promoted by TGFbeta superfamily members

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

positive regulation of osteoblast differentiation

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

CYR61 regulates BMP-2-dependent osteoblast differentiation through the {alpha}v{beta}3 integrin/integrin-linked kinase/ERK pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

TAZ, a transcriptional modulator of mesenchymal stem cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

Reciprocal roles of MSX2 in regulation of osteoblast and adipocyte differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

embryonic heart tube anterior/posterior pattern specification

1 reference

8 April 2019

Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

osteoblast differentiation

8 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

Involvement of endogenous bone morphogenetic protein (BMP) 2 and BMP6 in bone formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

Akt promotes BMP2-mediated osteoblast differentiation and bone development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

SWI/SNF chromatin remodeling complex is obligatory for BMP2-induced, Runx2-dependent skeletal gene expression that controls osteoblast differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

Wnt11 promotes osteoblast maturation and mineralization through R-spondin 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

Akt promotes BMP2-mediated osteoblast differentiation and bone development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

Wnt11 promotes osteoblast maturation and mineralization through R-spondin 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

positive regulation of odontogenesis

1 reference

8 April 2019

Comparative analysis of TGF beta s, BMPs, IGF1, msxs, fibronectin, osteonectin and bone sialoprotein gene expression during normal and in vitro-induced odontoblast differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

positive regulation of osteoblast proliferation

1 reference

8 April 2019

CYR61 regulates BMP-2-dependent osteoblast differentiation through the {alpha}v{beta}3 integrin/integrin-linked kinase/ERK pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

response to hypoxia

1 reference

8 April 2019

Bmp2 and Bmp4 exert opposing effects in hypoxic pulmonary hypertension

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

positive regulation of cell migration

1 reference

8 April 2019

CYR61 regulates BMP-2-dependent osteoblast differentiation through the {alpha}v{beta}3 integrin/integrin-linked kinase/ERK pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

cellular response to growth factor stimulus

1 reference

8 April 2019

Comparative analysis of TGF beta s, BMPs, IGF1, msxs, fibronectin, osteonectin and bone sialoprotein gene expression during normal and in vitro-induced odontoblast differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

positive regulation of pathway-restricted SMAD protein phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

5 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

cardiac muscle tissue morphogenesis

1 reference

8 April 2019

Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

endocardial cushion morphogenesis

multicellular organism development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

1 reference

8 April 2019

positive regulation of gene expression

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

Snorc is a novel cartilage specific small membrane proteoglycan expressed in differentiating and articular chondrocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

positive regulation of transcription by RNA polymerase II

Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development

10 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

Alternative neural crest cell fates are instructively promoted by TGFbeta superfamily members

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

Analysis of epithelial-mesenchymal interactions in the initial morphogenesis of the mammalian tooth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

Bmp2 and Bmp4 exert opposing effects in hypoxic pulmonary hypertension

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

Molecular mechanisms of cell and tissue interactions during early tooth development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

Id genes are direct targets of bone morphogenetic protein induction in embryonic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

Bone morphogenetic proteins (BMP-2 and BMP-3) induce the late phase expression of the proto-oncogene c-fos in murine osteoblastic MC3T3-E1 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

regulation of signaling receptor activity

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

negative regulation of gene expression

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

Myogenin protein stability is decreased by BMP-2 through a mechanism implicating Id1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

negative regulation of transcription by RNA polymerase II

Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

response to bacterium

1 reference

8 April 2019

Impact of lactobacilli on orally acquired listeriosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

BMP signaling pathway

Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4

9 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

Neogenin inhibits HJV secretion and regulates BMP-induced hepcidin expression and iron homeostasis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

A novel neural-specific BMP antagonist, Brorin-like, of the Chordin family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

C-terminal domain (CTD) small phosphatase-like 2 modulates the canonical bone morphogenetic protein (BMP) signaling and mesenchymal differentiation via Smad dephosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

Akt promotes BMP2-mediated osteoblast differentiation and bone development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

cell development

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

positive regulation of bone mineralization

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

8 April 2019

CYR61 regulates BMP-2-dependent osteoblast differentiation through the {alpha}v{beta}3 integrin/integrin-linked kinase/ERK pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

Transforming growth factor beta, conserved site

has part(s)

1 reference

TGF-beta, propeptide

1 reference

Transforming growth factor-beta, C-terminal

1 reference