(Q14887711)

Ubiquitin-like domain superfamily

1 reference

Protein kinase-like domain superfamily

1 reference

Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily

1 reference

Phosphatidylinositol kinase family

1 reference

Armadillo-type fold

1 reference

membrane protein

1 reference

inferred from GOA cell component → membrane

Phosphatidylinositol 3-/4-kinase, catalytic domain, protein family

1 reference

Phosphatidylinositol 3-kinase, C2 domain, protein family

1 reference

Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain, protein family

1 reference

PI3Kalpha, catalytic domain, protein family

1 reference

Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain, protein family

1 reference

Phosphoinositide 3-kinase, accessory (PIK) domain, protein family

1 reference

Phosphatidylinositol 3/4-kinase, conserved site, protein family

1 reference

1 reference

25 May 2022

1 reference

25 May 2022

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

1 reference

9 May 2019

nucleotide binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

1 reference

9 May 2019

1-phosphatidylinositol-3-kinase activity

4 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42337&geneProductId=UniProtKB:P42337

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42337&geneProductId=UniProtKB:P42337

16 July 2018

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42337&geneProductId=UniProtKB:P42337

16 July 2018

Lamellipodium extension and cadherin adhesion: two cell responses to cadherin activation relying on distinct signalling pathways

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42337&geneProductId=UniProtKB:P42337

protein kinase activator activity

1 reference

9 May 2019

Phosphatidylinositol 3-kinase (PI3K) signaling via glycogen synthase kinase-3 (Gsk-3) regulates DNA methylation of imprinted loci

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

1-phosphatidylinositol-4-phosphate 3-kinase activity

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

protein serine/threonine kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

1 reference

9 May 2019

protein binding

5 references

9 May 2019

The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

9 May 2019

Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

9 May 2019

Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

9 May 2019

Co-recruitment analysis of the CBL and CBLB signalosomes in primary T cells identifies CD5 as a key regulator of TCR-induced ubiquitylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

9 May 2019

Bioinformatics and cellular signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

insulin receptor substrate binding

1 reference

9 May 2019

Involvement of tissue plasminogen activator in onset and effector phases of experimental allergic encephalomyelitis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

ATP binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

1 reference

9 May 2019

kinase activity

Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

phosphatidylinositol 3-kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

1 reference

9 May 2019

phosphatidylinositol-4,5-bisphosphate 3-kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

9 May 2019

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

1-phosphatidylinositol-3-kinase activity

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

9 May 2019

Lamellipodium extension and cadherin adhesion: two cell responses to cadherin activation relying on distinct signalling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

phosphatidylinositol-3,4-bisphosphate 5-kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

1 reference

9 May 2019

cell component

plasma membrane

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

lamellipodium

1 reference

9 May 2019

Lamellipodium extension and cadherin adhesion: two cell responses to cadherin activation relying on distinct signalling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

cytoplasm

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

phosphatidylinositol 3-kinase complex, class IA

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

cytosol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

1 reference

9 May 2019

phosphatidylinositol 3-kinase complex

TAS

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

9 May 2019

The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

membrane

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

negative regulation of neuron apoptotic process

biological process

1 reference

9 May 2019

Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

protein kinase B signaling

1 reference

9 May 2019

Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

regulation of multicellular organism growth

1 reference

9 May 2019

Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

hypomethylation of CpG island

1 reference

9 May 2019

Phosphatidylinositol 3-kinase (PI3K) signaling via glycogen synthase kinase-3 (Gsk-3) regulates DNA methylation of imprinted loci

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

positive regulation of peptidyl-serine phosphorylation

1 reference

9 May 2019

Phosphatidylinositol 3-kinase (PI3K) signaling via glycogen synthase kinase-3 (Gsk-3) regulates DNA methylation of imprinted loci

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

1 reference

16 July 2018

PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42337&geneProductId=UniProtKB:P42337

angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

1 reference

9 May 2019

glucose metabolic process

1 reference

9 May 2019

Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

phagocytosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

1 reference

9 May 2019

energy homeostasis

1 reference

9 May 2019

Adipose tissue insulin resistance due to loss of PI3K p110α leads to decreased energy expenditure and obesity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

regulation of gene expression

1 reference

9 May 2019

Involvement of heat shock protein (Hsp)90 beta but not Hsp90 alpha in antiapoptotic effect of CpG-B oligodeoxynucleotide

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

negative regulation of fibroblast apoptotic process

1 reference

9 May 2019

PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

liver development

1 reference

9 May 2019

Adipose tissue insulin resistance due to loss of PI3K p110α leads to decreased energy expenditure and obesity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

adipose tissue development

1 reference

9 May 2019

Adipose tissue insulin resistance due to loss of PI3K p110α leads to decreased energy expenditure and obesity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

regulation of cellular respiration

1 reference

9 May 2019

Adipose tissue insulin resistance due to loss of PI3K p110α leads to decreased energy expenditure and obesity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

regulation of genetic imprinting

1 reference

9 May 2019

Phosphatidylinositol 3-kinase (PI3K) signaling via glycogen synthase kinase-3 (Gsk-3) regulates DNA methylation of imprinted loci

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

cellular response to glucose stimulus

1 reference

9 May 2019

Adipose tissue insulin resistance due to loss of PI3K p110α leads to decreased energy expenditure and obesity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

phosphatidylinositol-mediated signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42337&geneProductId=UniProtKB:P42337

1 reference

16 July 2018

phosphatidylinositol-3-phosphate biosynthetic process

1 reference

16 July 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42337&geneProductId=UniProtKB:P42337

activation of protein kinase activity

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

phosphorylation

Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

adaptive immune response

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42337&geneProductId=UniProtKB:P42337

1 reference

16 July 2018

inflammatory response

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42337&geneProductId=UniProtKB:P42337

1 reference

16 July 2018

platelet activation

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

innate immune response

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42337&geneProductId=UniProtKB:P42337

1 reference

16 July 2018

cell chemotaxis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42337&geneProductId=UniProtKB:P42337

1 reference

16 July 2018

positive regulation of smooth muscle cell proliferation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

negative regulation of gene expression

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

cell migration

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

phosphatidylinositol-3-phosphate biosynthetic process

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

phosphatidylinositol phosphate biosynthetic process

regulation of protein phosphorylation

1 reference

9 May 2019

PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337

Phosphatidylinositol 3-kinase, C2 domain

has part(s)

1 reference

Phosphoinositide 3-kinase, accessory (PIK) domain

1 reference

Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain

1 reference

Phosphatidylinositol 3-/4-kinase, catalytic domain

1 reference

Phosphatidylinositol 3/4-kinase, conserved site

1 reference

Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain

1 reference

PI3Kalpha, catalytic domain

1 reference