(Q14872987)

tumor protein p73

1 reference

p53-like tetramerisation domain superfamily

1 reference

p53/RUNT-type transcription factor, DNA-binding domain superfamily

1 reference

Sterile alpha motif/pointed domain superfamily

1 reference

Tumour protein p73, SAM domain, protein family

1 reference

Sterile alpha motif domain, protein family

1 reference

p53, tetramerisation domain, protein family

1 reference

p53, DNA-binding domain, protein family

1 reference

1 reference

25 May 2022

1 reference

25 May 2022

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JJP2

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JJP2

14 February 2019

14 February 2019

Melanocyte and keratinocyte carcinogenesis: p53 family protein activities and intersecting mRNA expression profiles

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JJP2

DNA-binding transcription factor activity

The ubiquitin-protein ligase Itch regulates p73 stability

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JJP2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JJP2

14 February 2019

14 February 2019

TP53INP1 is a novel p73 target gene that induces cell cycle arrest and cell death by modulating p73 transcriptional activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JJP2

transcription factor binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JJP2

chromatin binding

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JJP2&geneProductId=UniProtKB:Q9JJP2

1 reference

24 April 2018

metal ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JJP2

1 reference

14 February 2019

RNA polymerase II cis-regulatory region sequence-specific DNA binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JJP2

damaged DNA binding

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JJP2&geneProductId=UniProtKB:Q9JJP2

1 reference

24 April 2018

identical protein binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JJP2

double-stranded DNA binding

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JJP2&geneProductId=UniProtKB:Q9JJP2

1 reference

24 April 2018

protein kinase binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JJP2

MDM2/MDM4 family protein binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JJP2

sequence-specific DNA binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JJP2

cell component

cytosol

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JJP2&geneProductId=UniProtKB:Q9JJP2

1 reference

24 April 2018

Golgi apparatus

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JJP2

intracellular membrane-bounded organelle

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JJP2

transcription regulator complex

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JJP2&geneProductId=UniProtKB:Q9JJP2

1 reference

24 April 2018

nucleoplasm

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JJP2

cell junction

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JJP2

nucleus

7 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JJP2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JJP2

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JJP2

14 February 2019

14 February 2019

Brn-3a/POU4F1 interacts with and differentially affects p73-mediated transcription

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JJP2

14 February 2019

p73 and p63 protein stability: the way to regulate function?

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JJP2

14 February 2019

Evidence that DeltaNp73 promotes neuronal survival by p53-dependent and p53-independent mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JJP2

14 February 2019

Developmental roles of p73 in Cajal-Retzius cells and cortical patterning

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JJP2

chromatin

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JJP2

cerebrospinal fluid secretion

biological process

1 reference

14 February 2019

p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JJP2

negative regulation of neuron apoptotic process

p73 is required for survival and maintenance of CNS neurons

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JJP2

14 February 2019

Evidence that DeltaNp73 promotes neuronal survival by p53-dependent and p53-independent mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JJP2

14 February 2019

An anti-apoptotic role for the p53 family member, p73, during developmental neuron death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JJP2

14 February 2019

p73 is required for survival and maintenance of CNS neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JJP2

14 February 2019

An anti-apoptotic role for the p53 family member, p73, during developmental neuron death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JJP2

digestive tract morphogenesis

1 reference

14 February 2019

p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JJP2

regulation of transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JJP2

1 reference

14 February 2019

cellular response to UV

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JJP2&geneProductId=UniProtKB:Q9JJP2

1 reference

24 April 2018

regulation of neuron apoptotic process

1 reference

14 February 2019

Evidence that DeltaNp73 promotes neuronal survival by p53-dependent and p53-independent mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JJP2

neuron development

1 reference

14 February 2019

p73 is required for survival and maintenance of CNS neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JJP2

positive regulation of apoptotic signaling pathway

1 reference

14 February 2019

TP53INP1 is a novel p73 target gene that induces cell cycle arrest and cell death by modulating p73 transcriptional activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JJP2

negative regulation of transcription by RNA polymerase II

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JJP2&geneProductId=UniProtKB:Q9JJP2

1 reference

24 April 2018

post-embryonic development

protein tetramerization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JJP2

1 reference

14 February 2019

transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JJP2&geneProductId=UniProtKB:Q9JJP2

1 reference

24 April 2018

positive regulation of transcription, DNA-templated

mitotic G1 DNA damage checkpoint signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JJP2&geneProductId=UniProtKB:Q9JJP2

1 reference

24 April 2018

regulation of mitotic cell cycle

1 reference

14 February 2019

Directed expression of dominant-negative p73 enables proliferation of cardiomyocytes in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JJP2

regulation of gene expression

1 reference

14 February 2019

Directed expression of dominant-negative p73 enables proliferation of cardiomyocytes in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JJP2

cell cycle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JJP2

1 reference

14 February 2019

forebrain development

1 reference

14 February 2019

Developmental roles of p73 in Cajal-Retzius cells and cortical patterning

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JJP2

negative regulation of cardiac muscle cell proliferation

1 reference

14 February 2019

Directed expression of dominant-negative p73 enables proliferation of cardiomyocytes in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JJP2

inflammatory response

1 reference

14 February 2019

p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JJP2

positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

1 reference

14 February 2019

Frag1, a homolog of alternative replication factor C subunits, links replication stress surveillance with apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JJP2

response to gamma radiation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JJP2&geneProductId=UniProtKB:Q9JJP2

1 reference

24 April 2018

hippocampus development

1 reference

14 February 2019

p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JJP2

response to X-ray

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JJP2&geneProductId=UniProtKB:Q9JJP2

1 reference

24 April 2018

positive regulation of transcription by RNA polymerase II

ISS

DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JJP2&geneProductId=UniProtKB:Q9JJP2

1 reference

24 April 2018

transcription by RNA polymerase II

1 reference

24 April 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JJP2&geneProductId=UniProtKB:Q9JJP2

negative regulation of cell population proliferation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JJP2

release of cytochrome c from mitochondria

1 reference

14 February 2019

Evidence that DeltaNp73 promotes neuronal survival by p53-dependent and p53-independent mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JJP2

negative regulation of JUN kinase activity

1 reference

14 February 2019

Evidence that DeltaNp73 promotes neuronal survival by p53-dependent and p53-independent mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JJP2

positive regulation of apoptotic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JJP2

negative regulation of neuron differentiation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JJP2

positive regulation of oligodendrocyte differentiation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JJP2