Medicham debuted in As Long as I'm with My Friends, quietly meditating as Chalce and Sidian sat quietly. It expertly avoided direct contact with Coral's Glalie when the former was whining about her boredom.
In The Plan to Capture Rayquaza, Medicham helped oversee the operation to summon the Black Rayquaza at a lighthouse near Levincia. When the Legendary Pokémon arrived, Medicham, Coral's Glalie, and Sidian's Garganacl joined forces to damage it with their combined attacks. When Chalce tried to catch Rayquaza with an Ultra Ball, Roy's Wattrel knock the Ball away with Spark, but Medicham managed to knock the Storm Petrel Pokémon out of the sky with Psybeam. When Dot arrived to deactivate the generator that was luring in Rayquaza, Medicham battled Quaxly and Tinkatink, but this was merely a distraction to allow Dot to deactivate the generator. When Rayquaza unleashed a Draco Meteor, Medicham tried to stop it with Zen Headbutt, but was efortlessly knocked down by the move.
In HZ064, Medicham uses its psychic powers in order to move a large rock, causing Liko to get separated from Dot and Roy whilst on Glaseado Mountain, as part of Spinel's plans. In HZ066, Medicham was used to battle and stall Dot and her Quaxwell to prevent them from interfering with Chalce's data stealing plans. After Chalce acquired the data regarding Terapagos, she recalled Medicham and escaped with via her Xatu's Teleport.
