Bisoprololum

Cave: notitiae huius paginae nec praescriptiones nec consilia medica sunt.

Bisoprololum est substantia chemica beta-receptoria typi primi inhibens et propterea medicamentum antihypertensivum velut antiarrhythmicum classis II est.

Bisoprololum in ordinis mundi sanitarii indicem exemplarem medicamentorum essentialium receptum est.

Natura Bisoprololi

Natura chemica

**Bisoprololum** beta₁-receptoria valde selective inhibet.

Bisoprololum est beta₁-receptoriorum inhibitor. Structura eius chemica est (RS)-1-[4-(2-isopropoxyethoxymethyl)phenoxy]-3-isopropylamino-2-propanolum.

Formula chemica est C₁₈H₃₁NO₄, massa molaris 325.45 g/mol. Codex ATC est C07AB07 (WHO).

Natura pharmacologica

Pharmacocinetica

Solubilitas in aqua est 2.24 g·mol⁻¹ (25 °C), accessibilitas biologica 90%. Tempus semivitae biologicum $t_{\frac {1}{2}}$ .^[1]10 – 12 h est.

Bisoprololum substratum et Cytochromatis P450 CYP2D6 ( (R)-( )-bisoprololum > (S)-(-)-bisoprololum ) et CYP3A4 ( (R)=(S) ) est.^[2]

Interactiones

Cum Bisoprololum subtratum enzymi CYP3A4 esset, inhibitores CYP3A4 effectus Bisoprololi augere possint, inductores invicem diminuere, per exemplum:

Pharmaca cum effectibus Bisoprololi substrati
Inhibitores cum Bisoprololi effectibus fortioribus	Inductores cum Bisoprololi effectibus minoribus
Antihypertensiva Calcii canalium inhibitores Diltiazemum Felodipinum Antiarrhythmica Amiodaronum Dronedaronum Antidepressiva Fluvoxaminum Nefazodonum (forte) Diuretica/Hormonta Conivaptanum (forte) Antibiotica Ciprofloxacinum Macrolida Clarithromycinum (forte) Erythromycinum (forte) Telithromycinum (forte) Antiemetica Aprepitantum Fungicida/-statica Fluconazolum Ketoconazolum (forte) Isavuconazolum Itraconazolum (forte) Posaconazolum (forte) Voriconazolum (forte) Proteasis inhibitores Atazanavirum-Ritonavirum Boceprevirum (forte) Cobicistatum (forte) Indinavirum (forte) Lopinavirum cum Ritonaviro (forte) Nelfinavirum (forte) Ritonavirum (forte) Saquinavirum (forte) Telaprevirum (forte) Idelalisibum (forte) Imatinibum Nilotinibum Ribociblibum (forte) Glucocorticoides Dexamethasonum (forte) Verapamilum Hormonta GH Plantae Fructus averrhoae carambolae Silybum marianum	Anticonvulsiva Carbamazepinum (forte, quoque P-gp) Phenytoinum (forte) Fosphenytoinum (forte) Oxcarbazepinum (forte) Eslicarbazepinacetatum Topiramatum Phenobarbitalum (forte) Primidonum (forte) Antidepressiva Hypericum perforatum (forte, quoque P-gp) Antihypertensiva Bosentanum (forte, endothelini receptoris inhibitor) Substantiae antiretrovirales Efavirenzum (forte) Etravirinum (forte) Nevirapinum (forte) Substantiae antineoplasticae Dabrafenibum Enzalutamidum Mitotanum (forte) Antibiotica Rifabutinum (forte) Rifapentinum (forte) Nafcillinum (forte) Rifampicinum (forte) Hormonta Triiodthyroninum (T3) Antiandrogena Apalutamidum Modafinilum Quercetinum Capsaicinum

Notae

↑ http://goldbook.iupac.org/B00658.html
↑ Yuji Horikiri; Takehiko Suzuki; Masakazu Mizobe (March 1998). "Pharmacokinetics and metabolism of bisoprolol enantiomers in humans". Journal of Pharmaceutical Sciences 87 (3): 289–294

Nexus interni

Cor

[1] ttp://goldbook.iupac.org/B00658.html

[2] Yuji Horikiri; Takehiko Suzuki; Masakazu Mizobe (March 1998). "Pharmacokinetics and metabolism of bisoprolol enantiomers in humans". Journal of Pharmaceutical Sciences 87 (3): 289–294

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