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하이드록시카복실산 수용체 3

위키백과, 우리 모두의 백과사전.

하이드록시카복실산 수용체 3(영어: hydroxycarboxylic acid receptor 3, HCA3)는 사람에서 HCAR3 유전자에 의해 암호화되는 단백질이다.[1][2] 니아신 수용체 2(영어: niacin receptor 2, NIACR2), G 단백질 연결 수용체 109B(영어: G protein-coupled receptor 109B, GPR109B)라고도 한다.[3] 하이드록시카복실산 수용체 3(HCA3)은 다른 하이드록시카복실산 수용체인 하이드록시카복실산 수용체 1(HCA1) 및 하이드록시카복실산 수용체 2(HCA2)와 마찬가지로 Gi/o-연결 G 단백질 연결 수용체(GPCR)이다.[4][5] 하이드록시카복실산 수용체 3(HCA3)의 주요 내인성 작용제는 3-하이드록시옥탄산 및 키뉴렌산이다.[4][5][6] 하이드록시카복실산 수용체 3(HCA3)는 또한 니아신(일명 니코틴산)에 대한 저친화성 생체분자 표적이다.[7]

같이 보기

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각주

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  1. ↑ “Entrez Gene: GPR109B G protein-coupled receptor 109B”. 
  2. ↑ Nomura H, Nielsen BW, Matsushima K (October 1993). “Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors”. 《International Immunology》 5 (10): 1239–49. doi:10.1093/intimm/5.10.1239. PMID 7505609. 
  3. ↑ Offermanns S, Colletti SL, Lovenberg TW, Semple G, Wise A, IJzerman AP (June 2011). “International Union of Basic and Clinical Pharmacology. LXXXII: Nomenclature and Classification of Hydroxy-carboxylic Acid Receptors (GPR81, GPR109A, and GPR109B)”. 《Pharmacological Reviews》 63 (2): 269–90. doi:10.1124/pr.110.003301. PMID 21454438. 
  4. ↑ 가 나 Offermanns S, Colletti SL, Lovenberg TW, Semple G, Wise A, IJzerman AP (June 2011). “International Union of Basic and Clinical Pharmacology. LXXXII: Nomenclature and Classification of Hydroxy-carboxylic Acid Receptors (GPR81, GPR109A, and GPR109B)”. 《Pharmacological Reviews》 63 (2): 269–90. doi:10.1124/pr.110.003301. PMID 21454438. 
  5. ↑ 가 나 S Offermanns, SL Colletti, AP IJzerman, TW Lovenberg, G Semple, A Wise, MG Waters. “Hydroxycarboxylic acid receptors”. 《IUPHAR/BPS Guide to Pharmacology》. International Union of Basic and Clinical Pharmacology. 2018년 7월 13일에 확인함. 
  6. ↑ Kapolka, NJ; Taghon, GJ; Rowe, JB; Morgan, WM; Enten, JF; Lambert, NA; Isom, DG (2020년 6월 9일). “DCyFIR: a high-throughput CRISPR platform for multiplexed G protein-coupled receptor profiling and ligand discovery.”. 《Proceedings of the National Academy of Sciences of the United States of America》 117 (23): 13117–13126. Bibcode:2020PNAS..11713117K. doi:10.1073/pnas.2000430117. PMC 7293659. PMID 32434907. 
  7. ↑ Peters, A; Krumbholz, P; Jäger, E; Heintz-Buschart, A; Çakir, MV; Rothemund, S; Gaudl, A; Ceglarek, U; Schöneberg, T; Stäubert, C (May 2019). “Metabolites of lactic acid bacteria present in fermented foods are highly potent agonists of human hydroxycarboxylic acid receptor 3.”. 《PLOS Genetics》 15 (5): e1008145. doi:10.1371/journal.pgen.1008145. PMC 6532841. PMID 31120900. 

외부 링크

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더 읽을거리

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  • Nomura H, Nielsen BW, Matsushima K (October 1993). “Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors”. 《International Immunology》 5 (10): 1239–49. doi:10.1093/intimm/5.10.1239. PMID 7505609. 
  • Zingoni A, Rocchi M, Storlazzi CT, Bernardini G, Santoni A, Napolitano M (June 1997). “Isolation and chromosomal localization of GPR31, a human gene encoding a putative G protein-coupled receptor”. 《Genomics》 42 (3): 519–23. doi:10.1006/geno.1997.4754. hdl:11573/245592. PMID 9205127. 
  • Irobi J, Nelis E, Verhoeven K, De Vriendt E, Dierick I, De Jonghe P, Van Broeckhoven C, Timmerman V (June 2002). “Mutation analysis of 12 candidate genes for distal hereditary motor neuropathy type II (distal HMN II) linked to 12q24.3”. 《Journal of the Peripheral Nervous System》 7 (2): 87–95. doi:10.1046/j.1529-8027.2002.02014.x. PMID 12090300. S2CID 8453412. 
  • Wise A, Foord SM, Fraser NJ, Barnes AA, Elshourbagy N, Eilert M, Ignar DM, Murdock PR, Steplewski K, Green A, Brown AJ, Dowell SJ, Szekeres PG, Hassall DG, Marshall FH, Wilson S, Pike NB (March 2003). “Molecular identification of high and low affinity receptors for nicotinic acid”. 《The Journal of Biological Chemistry》 278 (11): 9869–74. doi:10.1074/jbc.M210695200. PMID 12522134. 
  • Tunaru S, Kero J, Schaub A, Wufka C, Blaukat A, Pfeffer K, Offermanns S (March 2003). “PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect”. 《Nature Medicine》 9 (3): 352–5. doi:10.1038/nm824. PMID 12563315. S2CID 20451806. 
  • Soga T, Kamohara M, Takasaki J, Matsumoto S, Saito T, Ohishi T, Hiyama H, Matsuo A, Matsushime H, Furuichi K (March 2003). “Molecular identification of nicotinic acid receptor”. 《Biochemical and Biophysical Research Communications》 303 (1): 364–9. doi:10.1016/S0006-291X(03)00342-5. PMID 12646212. 
  • Toulza E, Mattiuzzo NR, Galliano MF, Jonca N, Dossat C, Jacob D, de Daruvar A, Wincker P, Serre G, Guerrin M (2007). “Large-scale identification of human genes implicated in epidermal barrier function”. 《Genome Biology》 8 (6): R107. doi:10.1186/gb-2007-8-6-r107. PMC 2394760. PMID 17562024. 
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