뉴로텐신 수용체 1

뉴로텐신 수용체 1(Neurotensin receptor type 1, NTR1)은 인간에서 NTSR1 유전자에 의해 암호화 된 단백질이다.^[1]^[2]

기능

NTR1이라고도 하는 뉴로텐신 수용체 1은 G단백질 결합 수용체의 초 군에 속하며 클래스 A GPCR로 간주된다. NTSR1은 여러 생물학적 변조를 통해 저혈압, 고혈당, 저체온증, 장 운동 및 분비를 조절한다.^[2]

리간드

ML314-β 어레스틴 편향 작용제^[3]
뉴로텐신(NT1)

같이 보기

뉴로텐신 수용체

각주

↑ “Chromosomal localization of mouse and human neurotensin receptor genes”. 《Mammalian Genome》 5 (5): 303–6. May 1994. doi:10.1007/BF00389545. PMID 8075503.
↑ ^가 ^나 “Entrez Gene: NTSR1 neurotensin receptor 1 (high affinity)”.
↑ “Discovery of ML314, a Brain Penetrant Non-Peptidic β-Arrestin Biased Agonist of the Neurotensin NTR1 Receptor”. 《ACS Med Chem Lett》 4 (9): 846–851. 2013. doi:10.1021/ml400176n. PMC 3940307. PMID 24611085.

추가 자료

“Neurotensin receptors: binding properties, transduction pathways, and structure”. 《Cellular and Molecular Neurobiology》 15 (5): 501–12. Oct 1995. doi:10.1007/BF02071313. PMID 8719037.
“Neurotensin and neurotensin receptors”. 《Trends in Pharmacological Sciences》 20 (7): 302–9. Jul 1999. doi:10.1016/S0165-6147(99)01357-7. PMID 10390649.
“Cloning and expression of a complementary DNA encoding a high affinity human neurotensin receptor”. 《FEBS Letters》 317 (1–2): 139–42. Feb 1993. doi:10.1016/0014-5793(93)81509-X. PMID 8381365.
“Characterization of the genomic structure, promoter region, and a tetranucleotide repeat polymorphism of the human neurotensin receptor gene”. 《The Journal of Biological Chemistry》 272 (2): 1315–22. Jan 1997. doi:10.1074/jbc.272.2.1315. PMID 8995438.
“Correlative ultrastructural distribution of neurotensin receptor proteins and binding sites in the rat substantia nigra”. 《The Journal of Neuroscience》 18 (20): 8473–84. Oct 1998. doi:10.1523/JNEUROSCI.18-20-08473.1998. PMID 9763490.
“TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction”. 《The Journal of Biological Chemistry》 274 (42): 30202–8. Oct 1999. doi:10.1074/jbc.274.42.30202. PMID 10514511.
“Neurotensin receptor-1 mRNA analysis in normal pancreas and pancreatic disease”. 《Clinical Cancer Research》 6 (2): 566–71. Feb 2000. PMID 10690540.
“A single amino acid of the human and rat neurotensin receptors (subtype 1) determining the pharmacological profile of a species-selective neurotensin agonist”. 《Biochemical Pharmacology》 60 (6): 793–801. Sep 2000. doi:10.1016/S0006-2952(00)00409-3. PMID 10930533.
“Molecular determinants underlying the formation of stable intracellular G protein-coupled receptor-beta-arrestin complexes after receptor endocytosis*”. 《The Journal of Biological Chemistry》 276 (22): 19452–60. Jun 2001. doi:10.1074/jbc.M101450200. PMID 11279203.
“Neurotensin induces mating in Saccharomyces cerevisiae cells that express human neurotensin receptor type 1 in place of the endogenous pheromone receptor”. 《European Journal of Biochemistry / FEBS》 268 (18): 4860–7. Sep 2001. doi:10.1046/j.0014-2956.2001.02407.x. PMID 11559354.
“Topography of the neurotensin (NT)(8-9) binding site of human NT receptor-1 probed with NT(8-13) analogs”. 《The Journal of Peptide Research》 59 (2): 55–61. Feb 2002. doi:10.1046/j.1397-002x.2001.10946.x. PMID 11906607.
“Neurotensin counteracts apoptosis in breast cancer cells”. 《Biochemical and Biophysical Research Communications》 295 (2): 482–8. Jul 2002. doi:10.1016/S0006-291X(02)00703-9. PMID 12150975.
“Neurotensin receptor-1 and -3 complex modulates the cellular signaling of neurotensin in the HT29 cell line”. 《Gastroenterology》 123 (4): 1135–43. Oct 2002. doi:10.1053/gast.2002.36000. PMID 12360476.
“Receptor trafficking via the perinuclear recycling compartment accompanied by cell division is necessary for permanent neurotensin cell sensitization and leads to chronic mitogen-activated protein kinase activation”. 《The Journal of Biological Chemistry》 279 (13): 12636–46. Mar 2004. doi:10.1074/jbc.M303384200. PMID 14699144.
“Sezary syndrome cells unlike normal circulating T lymphocytes fail to migrate following engagement of NT1 receptor”. 《The Journal of Investigative Dermatology》 122 (1): 111–8. Jan 2004. doi:10.1046/j.0022-202X.2003.22131.x. PMID 14962098.
“Neuropeptide neurotensin stimulates intestinal wound healing following chronic intestinal inflammation”. 《American Journal of Physiology. Gastrointestinal and Liver Physiology》 288 (4): G621–9. Apr 2005. doi:10.1152/ajpgi.00140.2004. PMID 15764810.

[pmid8075503-1] “Chromosomal localization of mouse and human neurotensin receptor genes”. 《Mammalian Genome》 5 (5): 303–6. May 1994. doi:10.1007/BF00389545. PMID 8075503.

[entrez-2] 가 ^나 “Entrez Gene: NTSR1 neurotensin receptor 1 (high affinity)”.

[pmid24611085-3] “Discovery of ML314, a Brain Penetrant Non-Peptidic β-Arrestin Biased Agonist of the Neurotensin NTR1 Receptor”. 《ACS Med Chem Lett》 4 (9): 846–851. 2013. doi:10.1021/ml400176n. PMC 3940307. PMID 24611085.

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