11/08/2024
Research Article
DRN and WUS are known to upregulate CLV3 in the shoot apical meristem of Arabidopsis, but how? Linjie Luo, Guoping Zhu, Zhong Zhao and co-workers show that DRN interferes with WUS dimerization and chromatin remodeling, thereby activating CLV3 transcription and helping to maintain the shoot stem cell pool.
Image credit: pbio.3002878
Current Issue October 2024
11/07/2024
Research Article
How do RNA viruses manipulate the host cell to establish replication factories? Kriti Kestur Biligiri, Shravanti Rampalli and co-authors identify a cytoplasmic form of Euchromatic Histone Methyltransferase 1 (EHMT1) and show that it methylates viral nucleoproteins, promoting inclusion body maturation and viral replication.
Image credit: pbio.3002871
11/07/2024
Research Article
How do repeated influenza infections generate such a complex immunological landscape? This study of influenza A/H3N2 in humans, by James Hay, Steven Riley and colleagues, estimates lifetime infection histories for 1,130 individuals, reconstructing influenza incidence and antibody patterns across age, location and time.
Image credit: pbio.3002864
11/07/2024
Research Article
Gulnara Tagirdzhanova, Robert Finn, Toby Spribille and co-workers reassemble 400 lichen metagenomes, recovering 1000 metagenome-assembled genomes (MAGs), and providing the most detailed survey to date of bacteria in lichens. Functional annotation of bacterial, fungal and algal MAGs suggests interdigitated vitamin prototrophies and auxotrophies, with implications for microbial cross-feeding.
Image credit: Pixabay user Euphoria246
11/05/2024
Methods and Resources
Integrating data from different experimental approaches into one model is challenging. Armando Romani, Michele Migliore, Szabolcs Káli, Henry Markram and co-authors present a community-based, full-scale in silico model of the rat hippocampal CA1 region that integrates diverse experimental data from synapse to network.
Image credit: pbio.3002861
11/05/2024
Methods and Resources
Determining how different cell types coordinate to form and maintain tissues is crucial to understand cancer and other pathologies. Katelyn Del Toro, Rosalyn Sayaman, William Curtis Hines and colleagues present a transcriptomic analysis of the twelve major cell types that make up the human breast, providing a resource to study cell-intrinsic characteristics and human breast tissue composition.
Image credit: pbio.3002820
11/05/2024
Perspective
Genomics-based predictions indicate that plants are able to make a vast array of undiscovered chemistry. This Perspective argues that we now have the potential to harness this capability at unprecedented scale for the discovery of new drugs.
Image credit: pbio.3002886
10/30/2024
Editorial
Simon Hanslmayr introduces a Collection which explores the present and possible futures of neurotechnology, as well as the scientific, technological and ethical challenges they face.
Image credit: Pixabay user Gerd Altmann
10/29/2024
Essay
TUS is a promising non-invasive solution to interface with specific brain regions with high precision. This Essay explores the challenges and proposes a roadmap for the evolution of TUS from a research tool to a clinically validated therapeutic.
Image credit: pbio.3002884
10/29/2024
Perspective
This Perspective discusses how closing the sensory feedback loop in brain implants and nerve electrodes for stimulation may improve rehabilitation and assistive systems for patients.
Image credit: pbio.3002866
Neurotechnology offers unprecedented opportunities to treat neural disorders, restore brain function and enhance cognitive abilities. This collection explores the present and possible futures of neurotechnology to improve human health and cognition.
Translating conservation and biodiversity research from the field into the real world is a complex problem. This collection discusses issues around economics, policy, and how to do research that answers questions that decision makers have.
Symbiosis research has become a holistic and pervasive field with a mature theoretical basis. This collection showcases symbiotic relationships across the tree of life, exploring their evolutionary basis and underlying mechanisms.
PLOS Biology is 20 and we are celebrating with a collection that contains articles that look back at landmark studies that we published, others that look past and future, and others discussing how publishing and open science have evolved and what is to come.
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This collection explores engineering strategies to help us adapt plants to a changing climate, including breeding techniques, genome engineering, synthetic biology and microbiome engineering.
November 12 - 16
Meet Editor in Chief Nonia Pariente ([email protected]).
December 10 - 13
Meet Senior Editor Roli Roberts ([email protected])
December 14 - 18
Meet Senior Editor Ines Alvarez-Garcia ([email protected])
February 27 - March 1
Meet Associate Editor Melissa Vazquez Hernandez ([email protected])
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