About
A farmer, pharmacist and an entrepreneur engaged in the area of phytopharmaceuticals…
Contributions
Activity
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Imagine two #IITK #graduates, both in Indian Police Services, and married 😀 ! What are the odds, right? To know the journey of this #power #couple…
Imagine two #IITK #graduates, both in Indian Police Services, and married 😀 ! What are the odds, right? To know the journey of this #power #couple…
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Here is a great opportunity of leading the Government's efforts to transform Science & Technology in the country by steering the newly launched…
Here is a great opportunity of leading the Government's efforts to transform Science & Technology in the country by steering the newly launched…
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Performance and field view of Lemongrass cv.Krishna Variety with citral (75-80%) @CSIR Cimap Hyderabad with Dr.Jnanesha AC and Ranjith Kumar…
Performance and field view of Lemongrass cv.Krishna Variety with citral (75-80%) @CSIR Cimap Hyderabad with Dr.Jnanesha AC and Ranjith Kumar…
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Experience
Education
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Maulana Abul Kalam Azad University of Technology, West Bengal formerly WBUT
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Antimicrobial Drug Discovery Research
Thesis: Design and Synthesis of Novel Pyrimidine Derivatives as Potent Antimicrobial Agents. -
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Specialization: Pharmaceutical Chemistry
Research: Design, Synthesis and Bioactivity Screening of Novel Substituted Quinazolin Derivatives. -
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Distance Education
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Volunteer Experience
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Teak Grower
TEAKNET
- Present 10 years
Environment
About TEAKNET, To promote interactions and share wealth of information among the stakeholders of teak wood sector, Teaknet of Asia Pacific Region was established in 1995 with the support of FAO Regional Office for Asia and the Pacific. Following the decision made in the Regional Teak Workshop 2007 India, the Secretariat of Teaknet was relocated in Kerala Forest Research Institute (KFRI) Peechi, India in 2008 in order to revitalise the functioning of Teaknet and to cater to the needs of…
About TEAKNET, To promote interactions and share wealth of information among the stakeholders of teak wood sector, Teaknet of Asia Pacific Region was established in 1995 with the support of FAO Regional Office for Asia and the Pacific. Following the decision made in the Regional Teak Workshop 2007 India, the Secretariat of Teaknet was relocated in Kerala Forest Research Institute (KFRI) Peechi, India in 2008 in order to revitalise the functioning of Teaknet and to cater to the needs of international stakeholders. Myanmar is retained as a Referral Centre for natural teak forest management.
To facilitate the exchange of information and share the technology among the international stakeholders the country-wise contact addresses of the teak growers are listed in the following link
http://www.teaknet.org/teak-growers -
Collaborative volunteer
Cochrane (formerly known as The Cochrane Collaboration)
- 5 years 8 months
Health
Partipated in the crowd sourcing for identifying the randomised clinical trials in Embase database.
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Research Collaborator
Community for Open Antimicrobial Drug Discovery (CO-ADD)
- 3 years 11 months
Health
Antimicrobial Drug Discovery Research Collaboration.
Publications
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Synthesis and in vitro antiviral evaluation of 4-substituted 3,4-dihydropyrimidinones
Bioorganic & Medicinal Chemistry Letters Volume 27, Issue 2, 2017, Pages 139–142
A series of 4-substituted 3,4-dihydropyrimidine-2-ones (DHPM) was synthesized, characterized by IR, 1H NMR, 13C NMR and HRMS spectra. The compounds were evaluated in vitro for their antiviral activity against a broad range of DNA and RNA viruses, along with assessment for potential cytotoxicity in diverse mammalian cell lines. Compound 4m, which possesses a long lipophilic side chain, was found to be a potent and selective inhibitor of Punta Toro virus, a member of the Bunyaviridae. For Rift…
A series of 4-substituted 3,4-dihydropyrimidine-2-ones (DHPM) was synthesized, characterized by IR, 1H NMR, 13C NMR and HRMS spectra. The compounds were evaluated in vitro for their antiviral activity against a broad range of DNA and RNA viruses, along with assessment for potential cytotoxicity in diverse mammalian cell lines. Compound 4m, which possesses a long lipophilic side chain, was found to be a potent and selective inhibitor of Punta Toro virus, a member of the Bunyaviridae. For Rift Valley fever virus, which is another Bunyavirus, the activity of 4m was negligible. DHPMs with a C-4 aryl moiety bearing halogen substitution (4b, 4c and 4d) were found to be cytotoxic in MT4 cells.
Other authors -
Design and synthesis of 3-(4-Ethylphenyl)-2-substituted amino-3H-quinazolin-4- ones as a novel class of analgesic and anti-inflammatory agents.
Journal of Enzyme Inhibition and Medicinal Chemistry, 2008; 9: 1–9
A new series of 3-(4-ethylphenyl)-2-substituted amino-3H-quinazolin-4-ones were synthesized by reacting the amino group of 2-hydrazino-3-(4-ethylphenyl)-3H-quinazolin-4-one from 4-ethyl aniline with a variety of aldehydes and ketones. The title compounds were investigated for analgesic, anti-inflammatory and ulcerogenic index activities. The compound 2-(N′-3-pentylidene-hydrazino)-3-(4-ethylphenyl)-3H-quinazolin-4-one (AS2) emerged as the most active compound of the series and was moderately…
A new series of 3-(4-ethylphenyl)-2-substituted amino-3H-quinazolin-4-ones were synthesized by reacting the amino group of 2-hydrazino-3-(4-ethylphenyl)-3H-quinazolin-4-one from 4-ethyl aniline with a variety of aldehydes and ketones. The title compounds were investigated for analgesic, anti-inflammatory and ulcerogenic index activities. The compound 2-(N′-3-pentylidene-hydrazino)-3-(4-ethylphenyl)-3H-quinazolin-4-one (AS2) emerged as the most active compound of the series and was moderately more potent than the reference standard diclofenac sodium. Interestingly the test compounds showed only mild ulcerogenic potential when compared to aspirin.
Other authors -
Synthesis and Pharmacological Investigation of Novel 4-(4-Ethyl phenyl)-1-substituted-4H-[1,2,4]triazolo[4,3-a]-quinazolin-5-ones as New Class of H1-Antihistaminic agents.
Journal of Heterocyclic Chemistry 45, 1 (2008). 1-8
A series of novel 4-(4-ethylphenyl)-1-substituted-4H-[1,2,4]triazolo[4,3-a]quinazolin-5-ones were synthesized by the cyclization of 2-hydrazino intermediate with various electrophile. The starting material 2-hydrazino compound was synthesized from 2-ethyl aniline by a new innovative route with improved yield. When tested for their in vivo H1-antihistaminic activity on conscious guinea pigs, all the test compounds significantly protected the animals from histamine induced bronchospasm. The…
A series of novel 4-(4-ethylphenyl)-1-substituted-4H-[1,2,4]triazolo[4,3-a]quinazolin-5-ones were synthesized by the cyclization of 2-hydrazino intermediate with various electrophile. The starting material 2-hydrazino compound was synthesized from 2-ethyl aniline by a new innovative route with improved yield. When tested for their in vivo H1-antihistaminic activity on conscious guinea pigs, all the test compounds significantly protected the animals from histamine induced bronchospasm. The compound II emerged as the most active compound of the series and it is more potent (73.93% protection) when compared to the reference standard, chlorpheniramine maleate (71% protection), it showed negligible sedation (10%) when compared to chlorpheniramine maleate (30%). Therefore compound II will serve as prototype molecule for further development as a new class of H1-antihistamines
Other authors -
Synthesis and pharmacological investigation of novel 3-(3-methylphenyl)-2-substituted amino-3H-quinazolin-4-ones as analgesic and anti-inflammatory agents.
Journal of Pharmacy and Pharmacology 59(5): 669-77.
A variety of novel 3-(3-methylphenyl)-2-substituted amino-3H-quinazolin-4-ones were synthesized by reacting the amino group of 2-hydrazino-3-(3-methylphenyl)-3H-quinazolin-4-one with a variety of aldehydes and ketones. The starting material 2-hydrazino-3-(3-methylphenyl)-3H-quinazolin-4-one was synthesized from 3-methyl aniline. The title compounds were investigated for analgesic, anti-inflammatory and ulcerogenic index activities. Compound…
A variety of novel 3-(3-methylphenyl)-2-substituted amino-3H-quinazolin-4-ones were synthesized by reacting the amino group of 2-hydrazino-3-(3-methylphenyl)-3H-quinazolin-4-one with a variety of aldehydes and ketones. The starting material 2-hydrazino-3-(3-methylphenyl)-3H-quinazolin-4-one was synthesized from 3-methyl aniline. The title compounds were investigated for analgesic, anti-inflammatory and ulcerogenic index activities. Compound 2-(1-ethylpropylidene-hydrazino)-3-(3-methylphenyl)-3H-quinazolin-4-one (AS2) was the most active analgesic agent. Compound 2-(1-methylbutylidene-hydrazino)-3-(3-methylphenyl)-3H-quinazolin-4-one (AS3) was the most active anti-inflammatory agent and was moderately more potent than the reference standard diclofenac sodium. The test compounds showed only mild ulcerogenic potential compared with aspirin.
Other authors -
Anti HIV, antibacterial and antifungal activities of some novel 2-methyl-3-(substituted methylamino)-(3H)-quinazolin-4-ones.
Indian Journal of Pharmaceutical Sciences 2007; 69:304-307.
The title compounds 2-methyl-3-(substituted methylamino)-(3 H )-quinazolin-4-ones were synthesized by condensing the active hydrogen atom of the amino group of 3-amino-2-methyl-(3 H )-quinazolin-4-one with formaldehyde and appropriate amines. Their structures were confirmed by spectral data (IR, 1H-NMR and Mass) and the purity was ascertained by elemental analysis. Investigation of antimicrobial activity of the test compounds was performed by agar dilution method against 7 pathogenic bacteria…
The title compounds 2-methyl-3-(substituted methylamino)-(3 H )-quinazolin-4-ones were synthesized by condensing the active hydrogen atom of the amino group of 3-amino-2-methyl-(3 H )-quinazolin-4-one with formaldehyde and appropriate amines. Their structures were confirmed by spectral data (IR, 1H-NMR and Mass) and the purity was ascertained by elemental analysis. Investigation of antimicrobial activity of the test compounds was performed by agar dilution method against 7 pathogenic bacteria, 3 pathogenic fungi and antiHIV activity against replication of HIV-1(IIIB) and HIV-2 (ROD) in MT-4 cells. The compounds exhibited significant antibacterial and antifungal activities.
Other authors -
Synthesis and pharmacological evaluation of some 3-phenyl-2-substituted-3H-quinazolin-4-one as analgesic, anti-inflammatory agents.
Bio organic and Medicinal Chemistry. 2007; 15(1): 235-41.
A variety of novel 3-phenyl-2-substituted-3H-quinazolin-4-ones were synthesized by reacting the amino group of 2-hydrazino-3-phenyl-3H-quinazolin-4-one with different aldehydes and ketones. The starting material 2-hydrazino-3-phenyl-3H-quinazolin-4-one was synthesized from aniline. The title compounds were investigated for analgesic, anti-inflammatory and ulcerogenic index activities. While the test compounds exhibited significant activity, compounds…
A variety of novel 3-phenyl-2-substituted-3H-quinazolin-4-ones were synthesized by reacting the amino group of 2-hydrazino-3-phenyl-3H-quinazolin-4-one with different aldehydes and ketones. The starting material 2-hydrazino-3-phenyl-3H-quinazolin-4-one was synthesized from aniline. The title compounds were investigated for analgesic, anti-inflammatory and ulcerogenic index activities. While the test compounds exhibited significant activity, compounds, 2-(N′-2-butylidene-hydrazino)-3-phenyl-3H-quinazolin-4-one (AS1), 2-(N′-3-pentylidene-hydrazino)-3-phenyl-3H-quinazolin-4-one (AS2) and 2-(N′-2-pentylidene-hydrazino)-3-phenyl-3H-quinazolin-4-one (AS3), exhibited moderate analgesic activity. The compound 2-(N′-2-pentylidene-hydrazino)-3-phenyl-3H-quinazolin-4-one (AS3) showed more potent anti-inflammatory activity when compared to the reference standard diclofenac sodium. Interestingly, the test compounds showed only mild ulcerogenic side effect when compared to aspirin.
Other authors -
Synthesis, analgesic, anti-inflammatory, ulcerogenic index and antibacterial activities of novel 2-methylthio-3-substituted-5,6,7,8-tetrahydro benzo(b)thieno [2,3-d]pyrimidin-4(3H)-ones.
European Journal of Medicinal Chemistry, 2006 41(11): 1293-300.
A variety of novel 2-methylthio-3-substituted-5,6,7,8-tetrahydrobenzo (b) thieno[2,3-d]pyrimidin-4(3H)-ones have been synthesized by reacting (2-methylthio-4-oxo-3H-5,6,7,8-tetrahydrobenzo (b) thieno[2,3-d]pyrimidin-3-yl)dithiocarbamic acid methyl ester (5) with a variety of amines. The starting material dithiocarbamate (5) was synthesized from 2-amino-3-carbethoxy-4,5,6,7-tetrahydrobenzo (b) thiophene (1) by a novel innovative route. The title compounds were investigated for analgesic…
A variety of novel 2-methylthio-3-substituted-5,6,7,8-tetrahydrobenzo (b) thieno[2,3-d]pyrimidin-4(3H)-ones have been synthesized by reacting (2-methylthio-4-oxo-3H-5,6,7,8-tetrahydrobenzo (b) thieno[2,3-d]pyrimidin-3-yl)dithiocarbamic acid methyl ester (5) with a variety of amines. The starting material dithiocarbamate (5) was synthesized from 2-amino-3-carbethoxy-4,5,6,7-tetrahydrobenzo (b) thiophene (1) by a novel innovative route. The title compounds were investigated for analgesic, anti-inflammatory, ulcerogenicity index and antibacterial activities. While the test compounds exhibited significant activity, the compounds 1-methyl-3-(2-methylthio-4-oxo-3H-5,6,7,8-tetrahydrobenzo (b) thieno[2,3-d]pyrimidin-3-yl)thiourea (A1), 1-dimethyl-3-(2-methylthio-4-oxo-3H-5,6,7,8-tetrahydrobenzo (b) thieno[2,3-d]pyrimidin-3-yl)thiourea (A2), 1-diethyl-3-(2-methylthio-4-oxo-3H-5,6,7,8-tetrahydrobenzo (b) thieno[2,3-d]pyrimidin-3-yl)thiourea (A3) and 1-pyrrolidinyl-3-(2-methylthio-4-oxo-3H-5,6,7,8-tetrahydrobenzo (b) thieno[2,3-d]pyrimidin-3-yl)thiourea (A4) showed more potent analgesic activity and the compounds 1-dimethyl-3-(2-methylthio-4-oxo-3H-5,6,7,8-tetrahydrobenzo (b) thieno[2,3-d]pyrimidin-3-yl)thiourea (A2), 1-diethyl-3-(2-methylthio-4-oxo-3H-5,6,7,8-tetrahydrobenzo (b) thieno-[2,3-d]pyrimidin-3-yl)thiourea (A3) and 1-pyrrolidinyl-3-(2-methylthio-4-oxo-3H-5,6,7,8-tetrahydrobenzo (b) thieno[2,3-d] pyrimidin-3-yl)thiourea (A4) showed more potent anti-inflammatory activity than the reference standard diclofenac sodium.
Other authors
Languages
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Tamil
Native or bilingual proficiency
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English
Full professional proficiency
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Bengali
Limited working proficiency
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Hindi
Limited working proficiency
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Malayalam
Limited working proficiency
Organizations
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Indian Association of Pharmaceutical Scientists and Technogists
Life Member
- Present -
Association of Pharmaceutical Teachers of India (APTI)
President, APTI - Bengal Branch (Life Member)
-President, APTI - West Bengal State Branch, Elected for the Term 2016 - 2019 - 2022 http://aptiindia.org/westbengal Association of Pharmaceutical Teachers of India (APTI) works for the development of Pharmacy profession in general and in particular to the pharmaceutical teachers. APTI is the national forum of pharmaceutical teachers of India found in 1966.
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Community for Open Antimicrobial Drug Discovery (CO-ADD), Australia
Collaborator
-Principal Investigator, at NSHM College of Pharmaceutical Technology, Kolkata in a collaborative project with the Community for Open Antimicrobial Drug Discovery (CO-ADD)
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Commonwealth Pharmacists Association
Member
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Open Innovation Drug Discovery (OIDD), Eli Lilly and Company, USA
Affiliation Coordinator and Investigator
-Research Collaboration
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National Magnetic Resonance Society (India)
Life Member
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