SigTuple

🔬 An Interesting Case of AML with Monocytic Differentiation We are excited to kick off a series where we share intriguing medical cases diagnosed using the SigTuple AI100. Our first case highlights the powerful diagnostic capabilities of our technology. Case Overview: A 57-year-old male presented with a two-month history of fever. A peripheral smear was analyzed using the SigTuple AI100, revealing the presence of blasts along with 21% cells with monocytic differentiation composed of promonocytes, monoblasts, and monocytes. CBC Findings: • Hemoglobin (Hb): 9.4 g/dl • WBC count: 38.5 x 10^3 /uL • Platelet count: 127 x 10^3 /uL Flow Cytometry Results: 60% of the blasts gated were positive for CD13, CD33, cMPO, HLA-DR, CD11b, CD64, CD123 AND CD38. NEGATIVE FOR T-CELL MARKERS, cCD3, cCD79a, CD34, CD20, KAPPA/LAMBDA, CD56, AND CD16. Impression: Acute Myeloid Leukemia (AML) with monocytic differentiation. Discussion: Acute myelomonocytic leukemia (AMML) is a distinct subtype of AML characterized by the proliferation of both neutrophil and monocyte precursors. According to the 2022 WHO classification, AMML accounts for 5-10% of AML cases and is more common in older individuals, with a median age of 50 years and a male-to-female ratio of 1.4:1. Key Features of AMML: • Evidence of both granulocytic and monocytic differentiation • Blasts/blast equivalents (myeloblasts, monoblasts, promonocytes) must comprise at least 20% of blood or bone marrow cells • Granulocytic differentiation is present but cells of monocytic lineage must be at least 20% of cells Microscopic(histological) Description: • Myeloblasts: High N:C ratios, round nuclei, variably granular cytoplasm, occasional Auer rods • Monoblasts: Large cells with abundant, moderately to intensely basophilic cytoplasm. May have pseudopod formation, scattered fine azurophilic granules, and vacuoles. Often with round nuclei with lacy chromatin and one or more large nucleoli • Promonocytes: have more irregular nuclei, typically with delicate folds and abundant, less basophilic cytoplasm which is more obviously granulated with occasional large azurophilic granules and vacuoles. This case underscores the critical role of advanced diagnostic tools like the SigTuple AI100 in identifying complex medical conditions accurately and efficiently. Stay tuned for more interesting cases in our series! Case courtesy: Dr. Arivarasan, Bose clinic - Madurai. #Leukemia #SigTuple #AIinHealthcare Dr. Renu Ethirajan Pranat Bhadani Suman Gautam Tathagato Rai Dastidar

🚀 Exciting News! 🚀 We are thrilled to invite you to visit SigTuple at the upcoming Association for Diagnostics & Laboratory Medicine (ADLM) event at McCormick Place in Chicago from July 30th to August 1st! Join us at Booth #4606 to experience the launch of SigTuple's latest innovation AS76, a multi-specimen digital pathology platform. ⭐ Why Visit Our Booth? • Be the first to experience the groundbreaking AS76 • Engage with our expert team and get hands-on demonstrations • Discover how AS76 can revolutionize medical diagnostics 📅 Schedule Your Visit: To ensure you get the most out of your visit, schedule a one-on-one session with our team by clicking on this link. https://lnkd.in/ej3-CkFi We can’t wait to show you how SigTuple is pushing the boundaries of medical technology. See you in Chicago! #ADLM2024 #MedicalInnovation #SigTuple Tathagato Rai Dastidar Pranat Bhadani Suman Gautam Dr. Renu Ethirajan Apurv Manjrekar

🔬 Excited to share an inspiring feature on our company SigTuple and our visionary founder Tathagato Rai Dastidar in YourStory Media! 🌟 The article, titled "Combatting misdiagnosis: SigTuple is automating examination of medical images to create better outcomes for patients," delves into how we're revolutionizing medical diagnostics with AI and robotics. From humble beginnings in Bengaluru to tackling critical diseases through automated analysis of blood and urine samples, SigTuple is on a mission to enhance diagnostic accuracy and speed, minimizing human error and improving patient outcomes. A special shoutout to our founder, Tathagat Rai Dastidar, whose journey from IIT Kharagpur to leading innovative projects at National Semiconductor, Yahoo! Search, American Express, and beyond, laid the foundation for this groundbreaking venture. Discover how our flagship product, AI100, is setting new standards in digital microscopy and deep learning, ensuring quicker, more accurate diagnostics while supporting pathologists with advanced AI-driven tools. We’re proud to be backed by esteemed investors like Endiya Partners, Accel, Chiratae Ventures, and Flipkart co-founder Binny Bansal, and to collaborate with major industry players such as Dr Lal Path Labs, HCG, Manipal Hospitals, and KRSNAA diagnostics. 🌍 SigTuple is committed to global expansion, with plans to enter the EU and US markets soon. Stay tuned for more updates as we strive to make a worldwide impact in healthcare! 💪 #AI #HealthTech #YourStory #SigTuple #GlobalExpansion https://lnkd.in/g8rRHKQw

A 58-year-old gentleman visited a tertiary care hospital with complaints of weakness, weight loss, and low blood counts. On examination, he was found to have pallor and splenomegaly but no lymphadenopathy. CBC examination revealed a WBC count of 3.4 x109/L, a Hb level of 9.9 gm/dl, and a platelet count of 75 x 109/L. Differential count was Neutrophils-06%, Lymphocytes-90%, Eosinophils-03%, Monocytes-01%. His peripheral blood smear was scanned on SigTuple AI100. With just one click, the pathologist accessed the scanned images of all the atypical lymphoid cells pre-classified by AI100, which were intermediate in size with mature nuclear chromatin and a moderate amount of grey-blue cytoplasm with short hair-like projections. The reporting pathologist suspected a chronic lymphoproliferative disorder after reviewing the cells pre-classified by AI100 and ordered Flow Cytometric analysis of the blood sample. These atypical hairy cells were positive for CD11c, CD19, CD20, CD22, CD25, CD103, CD123, and CD305 (LAIR) confirming the diagnosis of Hairy cell leukemia. Bone marrow aspiration yielded a dry tap and trephine biopsy showed moderate fibrosis( Grade 2-3 on Reticulin stain). BRAF V600E mutation which is the hallmark genetic mutation in Hairy cell leukemia turned out to be positive in this case. Thus, a timely diagnosis was offered with the aid of SigTuple AI100 and a targeted therapy was given to the patient. Case Courtesy: ACTREC, Tata Memorial Centre TMC, Mumbai Dr. Pavithra Devi Dr. Sharitha Naganna Dr. Chaitra C Dr. Gayathri Talapula

🌟 What an incredible event it has been for us at Startup Mahakumbh so far! 🚀 We are absolutely thrilled to share that we had the honor of hosting Debjani Ghosh, President of Nasscom, at our booth. It was an absolute delight to showcase our innovative solutions in Medtech and discuss the future of healthcare with such a distinguished guest. We're grateful for the opportunity to connect with industry leaders like Debjani Ghosh and Sateesh Andra to be part of such a dynamic ecosystem at the nasscom deeptech Pavilion. We cannot wait to see how the last day of the event unfolds for us! Join us at our Booth #DPTA01 at the nasscom deeptech Pavilion #SigTuple #nasscom #nasscomdeeptech #nasscomstartups #startupecosystem #deeptechstartups #startupmahakumbh

🚀 Our Booth #DPTA01 at the nasscom deeptech Pavilion is all set to welcome you! 🎉 SigTuple is thrilled to showcase and discuss our groundbreaking products designed to revolutionize healthcare at Startup Mahakumbh in New Delhi from March 18-20. Swing by our stall to dive deep into the future of Medtech innovation and explore how our solutions are reshaping the medical landscape. Let's embark on this journey together towards a healthier, more advanced tomorrow! See you soon! #SigTuple #nasscom #nasscomdeeptech #nasscomstartups #startupecosystem #deeptechstartups #startupmahakumbh

Visit us at Booth #DPTA01 nasscom deeptech pavilion, STARTUP Mahakhumb, Bharat Mandapam, New Delhi, 18-20 March. Startup Mahakumbh event, a first-of-its-kind event bringing together the entire startup ecosystem of India including startups, investors, incubators and accelerators, and industry leaders from several sectors, being held from March 18-20, 2024, at Bharat Mandapam and ITPO in New Delhi. Spearheaded by the collaborative efforts of ASSOCHAM, nasscom, Bootstrap Incubation and Advisory Foundation, TiE, and Indian Venture and Alternate Capital Association (IVCA), the event will have sector-focused pavilions, which will showcase India's most innovative startups. Step into the future of healthcare innovation with SigTuple, India's leading Deeptech in Medtech! Join us at the nasscom deeptech Pavilion during the Startup Mahakumbh, where we'll be showcasing our cutting-edge solutions meticulously crafted to tackle real-world challenges head-on. Don't miss out on this incredible opportunity to witness the future of healthcare unfold before your eyes! See you there! With the purpose of connecting startups with a spectrum of inventors such as VCs, angel investors, family offices, and HNIs- as well as potential corporate partners, the Startup Mahakumbh is expected to host 2000 startups, 50 unicorns, 10 thematic pavilions, 1000 investors, 300 incubators & accelerators, 3000 conference delegates, 10 country delegations, and 50,000 business visitors over the span of three days.  #nasscom #nasscomdeeptech #nasscomstartups  #startupecosystem #deeptechstartups #startupmahakumbh Ministry of Commerce and Industry, Government of India Department for Promotion of Industry and Internal Trade Invest India Startup India nasscom startups

Meet us at the nasscom deeptech pavilion at the Startup Mahakumbh event, a first-of-its-kind event bringing together the entire startup ecosystem of India including startups, investors, incubators and accelerators, and industry leaders from several sectors, being held from March 18-20, 2024, at Bharat Mandapam and ITPO in New Delhi. Spearheaded by the collaborative efforts of ASSOCHAM (The Associated Chambers of Commerce and Industry of India), nasscom, Bootstrap Incubation and Advisory Foundation, TiE, and Indian Venture and Alternate Capital Association (IVCA), the event will have sector-focused pavilions, which will showcase India's most innovative startups. We are pleased to invite you to the nasscom Deep Tech Pavilion at the Startup Mahakumbh as SigTuple present our solutions designed to address real-world problems. The nasscom deeptech Pavilion highlights the crucial role of tech innovations in tackling pressing global challenges.   With the purpose of connecting startups with a spectrum of inventors such as VCs, angel investors, family offices, and HNIs- as well as potential corporate partners, the Startup Mahakumbh is expected to host 2000 startups, 50 unicorns, 10 thematic pavilions, 1000 investors, 300 incubators & accelerators, 3000 conference delegates, 10 country delegations, and 50,000 business visitors over the span of three days.  #nasscom #nasscomdeeptech #nasscomstartups  #startupecosystem #deeptechstartups #startupmahakumbh Ministry of Commerce and Industry, Government of India Department for Promotion of Industry and Internal Trade Invest India Startup India nasscom startups

Microscopic review is the confirmatory step for most hematology malignancies and its very satisfying to see AI100 play its part in simplifying the microscopic review for the pathologist's! #AI #digitalpathology #evidencebasedreporting #casestudy

We are delighted to unveil a groundbreaking innovation at the upcoming Medlab Middle East event, taking place at the Dubai World Trade Center from February 5th to February 8th, 2024. 🌍 ✨ Introducing AS76: Replacing the Microscope! Be the first to witness the debut of AS76, our latest marvel in medical technology, designed to replace traditional microscopes. Join us at Stand No. Z6.B29 for live demonstrations and insightful discussions on how AS76 is set to redefine the standards of medical microscopy in the Middle East. 🔬 Explore Our Featured Products: 1️⃣ AI100: Automating Peripheral Blood Smear and Urine Microscopy 2️⃣ AS76: Unveiling for the First Time in the Middle East 🗓 Event Details: Date: February 5th to February 8th, 2024 Location: Dubai World Trade Center, Dubai Let's come together to shape the future of healthcare through innovation and technology. Your presence will make this event even more memorable! #medlabmiddleeast #healthcare #unveiling Looking forward to sharing this momentous occasion with you at Stand No. Z6.B29!