CD11a

O CD11a (cluster de diferenciación 11a) ou cadea alfa L de integrina é unha subunidade proteica da superficie de leucocitos codificada no xene ITGAL humano do cromosoma 16. Está implicado na adhesión celular e sinalización coestimulatoria. É a diana do fármaco efalizumab.

O xene ITGAL codifica a cadea alfa L de integrina. As integrinas son proteínas integrais de membrana heterodímeras compostas por unha cadea alfa e outra beta. Este dominio I que contén a alfa integrina combínase coa cadea beta 2 ou CD18 (ITGB2) para formar o antíxeno asociado á función do linfocito 1 (LFA-1), que se expresa en todos os linfocitos. O LFA-1 xoga un papel central na adhesión intercelular de leucocitos por medio de interaccións cos seus ligandos, as ICAMs 1-3 (moléculas de adhesión intercelular 1 á 3), e tamén funciona na sinalización coestimulatoria de linfocitos.^[1]

O Efalizumab actúa como inmunosupresor ao unirse ao CD11a.

Interaccións

O CD11a interacciona con ICAM-1.^[2]^[3]^[4]

Notas

↑ "Entrez Gene: ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)".
↑ Lu, C; Takagi J, Springer T A (2001). "Association of the membrane proximal regions of the alpha and beta subunit cytoplasmic domains constrains an integrin in the inactive state". J. Biol. Chem. (United States) 276 (18): 14642–8. ISSN 0021-9258. PMID 11279101. doi:10.1074/jbc.M100600200.
↑ Shimaoka, Motomu; Xiao Tsan, Liu Jin-Huan, Yang Yuting, Dong Yicheng, Jun Chang-Duk, McCormack Alison, Zhang Rongguang, Joachimiak Andrzej, Takagi Junichi, Wang Jia-Huai, Springer Timothy A (2003). "Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation". Cell (United States) 112 (1): 99–111. ISSN 0092-8674. PMID 12526797. doi:10.1016/S0092-8674(02)01257-6.
↑ Yusuf-Makagiansar, H; Makagiansar I T, Hu Y, Siahaan T J (2001). "Synergistic inhibitory activity of alpha- and beta-LFA-1 peptides on LFA-1/ICAM-1 interaction". Peptides (United States) 22 (12): 1955–62. ISSN 0196-9781. PMID 11786177. doi:10.1016/S0196-9781(01)00546-0.

Véxase tamén

Outros artigos

Bibliografía

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Ligazóns externas

MeshName - CD11a Antigen [1]
ITGAL Info con ligazons na Cell Migration Gateway

[1] "Entrez Gene: ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)".

[pmid11279101-2] Lu, C; Takagi J, Springer T A (2001). "Association of the membrane proximal regions of the alpha and beta subunit cytoplasmic domains constrains an integrin in the inactive state". J. Biol. Chem. (United States) 276 (18): 14642–8. ISSN 0021-9258. PMID 11279101. doi:10.1074/jbc.M100600200.

[pmid12526797-3] Shimaoka, Motomu; Xiao Tsan, Liu Jin-Huan, Yang Yuting, Dong Yicheng, Jun Chang-Duk, McCormack Alison, Zhang Rongguang, Joachimiak Andrzej, Takagi Junichi, Wang Jia-Huai, Springer Timothy A (2003). "Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation". Cell (United States) 112 (1): 99–111. ISSN 0092-8674. PMID 12526797. doi:10.1016/S0092-8674(02)01257-6.

[pmid11786177-4] Yusuf-Makagiansar, H; Makagiansar I T, Hu Y, Siahaan T J (2001). "Synergistic inhibitory activity of alpha- and beta-LFA-1 peptides on LFA-1/ICAM-1 interaction". Peptides (United States) 22 (12): 1955–62. ISSN 0196-9781. PMID 11786177. doi:10.1016/S0196-9781(01)00546-0.

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