DPH Tramadol

Caution or Dangerous

Both drugs increase the risk of serotonin syndrome. While at medical dosages this is unlikely to be of concern, recreational dosages should be avoided.

Saud, S., Khan, I., Asif, M., Ismail, O., Salam, A., Yang, T. J., & Norville, K. J. (2018). Serotonin Syndrome Presenting with Concomitant Tramadol and Diphenhydramine Use: A Case Report of an Unlikely Side-Effect. Cureus, 10(4). https://doi.org/10.7759/cureus.2421
Yeh, S. Y., Dersch, C., Rothman, R., & Cadet, J. L. (1999). Effects of antihistamines on 3,4-methylenedioxymethamphetamine-induced depletion of serotonin in rats. https://doi.org/10.1002/(sici)1098-2396(19990901)33:3<207::aid-syn5>3.0.co;2-8

@AlanaRm-rf-me this has a similar idea of the concern of SS. Do you think we should mark it as caution or dangerous?