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layout id title browsers contact depicted_by description domain funded_by homepage license preferredPrefix products publications repository tracker usages activity_status
ontology_detail
eco
Evidence and Conclusion Ontology
title label url
ECO Browser
ECO
email github label orcid
mgiglio99
Michelle Giglio
0000-0001-7628-5565
An ontology for experimental and other evidence statements.
investigations
ECO
id
eco.owl
id
eco.obo
id title preferred
ECO: the Evidence and Conclusion Ontology, an update for 2022.
true
id title
ECO, the Evidence & Conclusion Ontology: community standard for evidence information.
id title
Standardized description of scientific evidence using the Evidence Ontology (ECO)
description examples type user
ECO is used by the GO consortium for evidence on GO associations
description url
annotations to transmembrane transport
annotation
description examples publications type user
ECO is used by the Monarch Initiative for evidence types for disease to phenotype annotations.
description url
Parkinsonism: Characteristic neurologic anomaly resulting form degeneration of dopamine-generating cells in the substantia nigra, a region of the midbrain, characterized clinically by shaking, rigidity, slowness of movement and difficulty with walking and gait.
id title
The Monarch Initiative: an integrative data and analytic platform connecting phenotypes to genotypes across species
annotation
active

The Evidence & Conclusion Ontology (ECO) describes types of scientific evidence within the realm of biological research that can arise from laboratory experiments, computational methods, manual literature curation, and other means. Researchers can use these types of evidence to support assertions about things (such as scientific conclusions, gene annotations, or other statements of fact) that result from scientific research.

ECO comprises two high-level classes, evidence and assertion method, where evidence is defined as “a type of information that is used to support an assertion,” and assertion method is defined as “a means by which a statement is made about an entity.” Together evidence and assertion method can be combined to describe both the support for an assertion and whether that assertion was made by a human being or a computer. However, ECO is not used to make the assertion itself; for that, one would use another ontology, free text description, or some other means.

ECO was originally created around the year 2000 to support gene product annotation by the Gene Ontology. Today ECO is used by dozens of biomedical resources to capture evidence associated with assertions in biocuration.

For advice on requesting new terms, please see the Evidence & Conclusion Ontology wiki.