CCL17

CCL17
Structures disponibles
PDB	Recherche UniProt humaine: PDBe RCSB
Identifiants PDB
	1NR2, 1NR4
Identifiants
Aliases	CCL17
IDs externes	OMIM: 601520 MGI: 1329039 HomoloGene: 2246 GeneCards: CCL17
Position du gène (Homme)
Chr.	Chromosome 16 humain
Fin	57,416,063 bp
Position du gène (Souris)
Chr.	Chromosome 8 (souris)
Fin	95,538,664 bp
Expression génétique
	Fortement exprimé dans
	testicule; ; appendice iléo-cæcal; ; ganglion lymphatique; ; olfactory zone of nasal mucosa; ; upper lobe of left lung; ; vésicule biliaire; ; Glandes accessoires; ; rectum; ; cellule épithéliale bronchiale; ; skin of abdomen;
	Fortement exprimé dans
	embryon; ; morula; ; crête génitale; ; facial motor nucleus; ; lèvre; ; blastocyste; ; gyrus frontal supérieur; ; thymus; ; cellule de Sertoli; ; cortex visuel;
	Plus de données d'expression de référence
	Plus de données d'expression de référence
Gene Ontology
Fonction moléculaire	cytokine activity; CCR chemokine receptor binding; signaling receptor binding; chemokine activity; CCR4 chemokine receptor binding; liaison protéique;
Composant cellulaire	région extracellulaire; milieu extracellulaire;
Processus biologique	G protein-coupled receptor signaling pathway; negative regulation of myoblast differentiation; monocyte chemotaxis; chemokine-mediated signaling pathway; cellular response to tumor necrosis factor; cell-cell signaling; neutrophil chemotaxis; développent d'un organisme multicellulaire; chimiotaxie; positive regulation of GTPase activity; cellular response to interleukin-1; réponse immunitaire; positive regulation of ERK1 and ERK2 cascade; cellular response to interferon-gamma; lymphocyte chemotaxis; réponse inflammatoire; antimicrobial humoral immune response mediated by antimicrobial peptide; regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologues
	6361
	20295
	ENSG00000102970
	ENSMUSG00000031780
	Q92583
	n/a
	NM_002987
	NM_011332
	NP_002978
	n/a
	Wikidata
Voir/Editer Humain	Voir/Editer Souris

Le CCL17 (pour « CC chemokine ligand 17 ») est une chimiokine. Son gène, CCL17 est situé sur le chromosome 16 humain.

Rôles

Il se lie au CCR4. Il favorise la proliférations des lymphocyte T régulateurs^[5] et auxiliaire^[6].

En médecine

Son expression est augmentée dans l'asthme^[7], dans la dermatose allergique de contact^[8],dans la polyarthrite rhumatoïde^[9] et dans l'athérome^[10].

Notes et références

↑ ^{a b et c} GRCh38: Ensembl release 89: ENSG00000102970 - Ensembl, May 2017
↑ ^{a b et c} GRCm38: Ensembl release 89: ENSMUSG00000031780 - Ensembl, May 2017
↑ « Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine
↑ « Publications PubMed pour la Souris », sur National Center for Biotechnology Information, U.S. National Library of Medicine
↑ Mizukami Y, Kono K, Kawaguchi Y, Akaike H, Kamimura K, Sugai H, Fujii H. CCL17 and CCL22 chemokines within tumor microenvironment are related to accumulation of Foxp3 regulatory T cells in gastric cancer, Int J Cancer, 2008;122:2286–2293
↑ Tsunemi Y, Saeki H, Nakamura K et al. CCL17 transgenic mice show an enhanced Th2-type response to both allergic and non-allergic stimuli, Eur J Immunol, 2006;36:2116–2127
↑ Staples KJ, Hinks TS, Ward JA, Gunn V, Smith C, Djukanović R, Phenotypic characterization of lung macrophages in asthmatic patients: overexpression of CCL17, J Allergy Clin Immunol, 2012;130:1404–12
↑ Riis JL, Johansen C, Vestergaard C, Bech R, Kragballe K, Iversen L, Kinetics and differential expression of the skin-related chemokines CCL27 and CCL17 in psoriasis, atopic dermatitis and allergic contact dermatitis, Exp Dermatol, 2011;20:789–794
↑ Radstake TR, van der Voort R, ten Brummelhuis M et al. Increased expression of CCL18, CCL19, and CCL17 by dendritic cells from patients with rheumatoid arthritis, and regulation by Fc gamma receptors, Ann Rheum Dis 2005;64:359–367
↑ Weber C, Meiler S, Döring Y et al. CCL17-expressing dendritic cells drive atherosclerosis by restraining regulatory T cell homeostasis in mice, J Clin Invest, 2011;121:2898–2910

Portail de la biologie cellulaire et moléculaire

[refGRCh38Ensembl-1] {a b et c} GRCh38: Ensembl release 89: ENSG00000102970 - Ensembl, May 2017

[refGRCm38Ensembl-2] {a b et c} GRCm38: Ensembl release 89: ENSMUSG00000031780 - Ensembl, May 2017

[3] « Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine

[4] « Publications PubMed pour la Souris », sur National Center for Biotechnology Information, U.S. National Library of Medicine

[Mizukami_2008-5] Mizukami Y, Kono K, Kawaguchi Y, Akaike H, Kamimura K, Sugai H, Fujii H. CCL17 and CCL22 chemokines within tumor microenvironment are related to accumulation of Foxp3 regulatory T cells in gastric cancer, Int J Cancer, 2008;122:2286–2293

[Tsunemi_2006-6] Tsunemi Y, Saeki H, Nakamura K et al. CCL17 transgenic mice show an enhanced Th2-type response to both allergic and non-allergic stimuli, Eur J Immunol, 2006;36:2116–2127

[Staples_2012-7] Staples KJ, Hinks TS, Ward JA, Gunn V, Smith C, Djukanović R, Phenotypic characterization of lung macrophages in asthmatic patients: overexpression of CCL17, J Allergy Clin Immunol, 2012;130:1404–12

[Riis_2011-8] Riis JL, Johansen C, Vestergaard C, Bech R, Kragballe K, Iversen L, Kinetics and differential expression of the skin-related chemokines CCL27 and CCL17 in psoriasis, atopic dermatitis and allergic contact dermatitis, Exp Dermatol, 2011;20:789–794

[Radstake_2005-9] Radstake TR, van der Voort R, ten Brummelhuis M et al. Increased expression of CCL18, CCL19, and CCL17 by dendritic cells from patients with rheumatoid arthritis, and regulation by Fc gamma receptors, Ann Rheum Dis 2005;64:359–367

[Weber_2011-10] Weber C, Meiler S, Döring Y et al. CCL17-expressing dendritic cells drive atherosclerosis by restraining regulatory T cell homeostasis in mice, J Clin Invest, 2011;121:2898–2910

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