OSE Immunotherapeutics recrute un(e) 'Senior Scientist in Immuno-Inflammation' pour renforcer son équipe de recherche en immuno-inflammation. Voir notre offre : https://lnkd.in/eNGVgCUk
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📢 Don’t let dead cells mislead you! Safeguard your experiments with our Cell Health Package - Cell health assays by flow cytometry! ⚠️Cell health may not always be your first concern, but the inadvertent inclusion of sick or dead cells in experiments can dramatically affect the outcomes. ✅ The solution - Cell Health Package - Our cell health package encompasses a comprehensive range of assays designed to evaluate the health and viability of cells through flow cytometry. It includes the analysis of cell cycle, identification of apoptosis, and measurement of reactive oxygen species (ROS) generation. Cell cycle analysis: As cells progress through the cell cycle, their DNA content indicates their specific stage. Propidium Iodide (PI) stains the DNA to detect its content. Apoptosis: Annexin V and Propidium iodide staining to distinguish between live, apoptotic, and necrotic cells, offering insights into cellular apoptosis processes. ROS generation: Environmentally stressed cells often have elevated reactive oxygen species levels. DCHFDA detects ROS through oxidative conversion to a fluorescent product, measurable by flow cytometry. Our Cell Health Package service can be particularly beneficial for - 1. Biomedical Researchers 2. Pharmaceutical Companies 3. Academic Institutions 4. Environmental Scientists For bookings or inquiries, contact: Edna Joseph Email: [email protected] Phone: 91-7410045651 Venture Center (Official Account) Premnath Venugopalan Manisha Premnath Edna Joseph Sujaya Ingale Dr. Upasana Kapoor Narula #research #biomedical #pharma #cellstudies #pharmaceuticals #environment #science #academia #experiment #scientist #laboratory #analysis
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Pharmacy | Pharmaceutical | Molecular Dynamics | Docking software/tools | Industrial Process Chemicals Operation
🔬✨ Exploring the World of Research: Selecting the Best Molecules to Combat Chagas Disease! As a Pharmacy student and Research Assistant, I have the privilege of delving into the fascinating field of chemistry and pharmacology. Today, I want to share a glimpse of the work we are doing in the quest for more effective treatments for #Chagas #disease, a condition that affects many communities worldwide. To better understand how molecules interact with the enzyme Trypanothione Reductase (#TcTR), a crucial player in the fight against #Chagasdisease, we employ powerful simulation software like GROMACS. These tools allow us to dive into the microscopic world and observe how molecules behave at the atomic level. The post-docking molecule selection step is critical. We use specialized software like Autodock and OpnME to evaluate hundreds of molecules, searching for those with the lowest binding energy and the highest biological activity against TcTR. This meticulous screening is akin to finding a needle in a haystack but is essential in identifying promising candidates for future studies. This work is a significant step towards more effective treatments for Chagas disease and other neglected diseases. I am thankful to my team and the scientific community for their ongoing support on this journey. I am excited about the potential of these findings and look forward to sharing more updates on our progress. I still need to learn more and more about it but I’m happy to be improving as faster as I can. Together, we are making a difference in scientific research and the quest for solutions to global health challenges. 💪🌍 #ScientificResearch #Pharmacy #ChagasDisease #GROMACS #Autodock #OpnME #linkedin #linkedinlearning #drugs #drugspharmaceuticals
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From the latest issue of Pharmacology Matters: Sam Illingworth discusses the 'two-way dialogue' needed to engage the public in research work, a topic explored in his new handbook, 'Community Engagement for Researchers'. Read now: https://ow.ly/Tiqb50PJkHm
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Source: Annals of clinical and laboratory science A study found that the Beckman Access immunoassay for measuring testosterone levels had a significant positive bias in lower concentrations but a negative bias in higher concentrations compared to a reference LC-MS/MS method. This means that the immunoassay underestimated testosterone levels in males but overestimated them in females with low testosterone levels. Therefore, caution should be taken when interpreting testosterone values obtained by the Beckman Access immunoassay for the diagnosis of hypogonadism in males and androgen excess in females.
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How does solid state disorder affect drug degradation? The present study investigates the impact of the solid-state disorder of vortioxetine hydrobromide (HBr) on oxidative degradation under accelerated conditions. A range of solid-state disorders was generated via cryogenic ball milling. The solid-state properties were evaluated by calorimetry, infrared-, and Raman spectroscopies. While salt disproportionation occurred upon milling, no chemical degradation occurred by milling. The amorphous fraction remained physically intact under ambient storage conditions. Subsequently, samples with representative disordered fractions were mixed with a solid oxidative stressor (PVP-H2O2 complex) and were compressed to compacts. The compacts were exposed to 40°C/75% RH for up to 6 h. The sample was periodically withdrawn and analyzed for the physical transformations and degradation. Two oxidative degradation products (DPs) were found to be formed, for which dissimilar relations to the degree of disorder and kinetics of formation were observed. The degradation rate of the major DP formation obtained by fitting the exponential model to the experimental data was found to increase up to a certain degree of disorder and decrease with a further increase in the disordered fraction. In contrast, the minor DP formation kinetics was found to increase monotonically with the increase in the disorder content. For the similar crystallinity level, the degradation trend (rate and extent) differed between the single-phase disorder generated by milling and physically mixed two-phase systems. Overall, the study demonstrates the importance of evaluating the physical and chemical (in)stabilities of the disordered solid state of a salt form of a drug substance, generated through mechano-activation. Dattatray Modhave @brenda barrios Jayant Iyer Ph.D. Amrit Paudel AAPS PharmSciTech American Association of Pharmaceutical Scientists (AAPS) | @aapscomms Daniel Davis, Ph.D., PharmD QI (Tony) ZHOU Claudio Salomon Michael Repka AAPS NIPER Student Chapter #degradation #oxidation #drugdevelopment #drugdelivery Link: https://rdcu.be/dweWE
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Biomedical Equipment is the set of instruments used in the field of medicine, biology and pharmacology. The design of biomedical equipment is directly related to Biomedical Instrumentation, in which instruments are designed to obtain information, apply treatments or perform chemical and biological processes.#snsinstitutions #snsdesignthinkers #designthinking
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Sue is an excellent scientist and leader.
I’m hiring in Stevenage!! Are you a hands on proteomics expert? Would you like to work in a multidisciplinary team that is looking for signatures of response for patients treated with immunotherapy? If that sounds like you then take a look at the below link to apply! https://lnkd.in/d-FybaGm
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