PEPPER

🇬🇧 📅 𝗦𝗔𝗩𝗘 𝗧𝗛𝗘 𝗗𝗔𝗧𝗘 -  December 6, 2024, Paris 𝗣𝗲𝗽𝗽𝗲𝗿 𝗖𝗼𝗹𝗹𝗼𝗾𝘂𝗶𝘂𝗺 - 𝗘𝗻𝗱𝗼𝗰𝗿𝗶𝗻𝗲 𝗗𝗶𝘀𝗿𝘂𝗽𝘁𝗼𝗿𝘀: 𝗟𝗲𝘁’𝘀 𝗔𝗰𝗰𝗲𝗹𝗲𝗿𝗮𝘁𝗲 𝗠𝗲𝘁𝗵𝗼𝗱 𝗩𝗮𝗹𝗶𝗱𝗮𝘁𝗶𝗼𝗻 𝗧𝗼𝗴𝗲𝘁𝗵𝗲𝗿 𝘁𝗼 𝗘𝗻𝗵𝗮𝗻𝗰𝗲 𝗢𝘂𝗿 𝗣𝗿𝗼𝘁𝗲𝗰𝘁𝗶𝗼𝗻 Join us at the 𝘌𝘴𝘱𝘢𝘤𝘦 𝘥𝘶 𝘊𝘦𝘯𝘵𝘦𝘯𝘢𝘪𝘳𝘦, 𝘔𝘢𝘪𝘴𝘰𝘯 𝘥𝘦 𝘭𝘢 𝘙𝘈𝘛𝘗, 𝘗𝘢𝘳𝘪𝘴 12𝘵𝘩 for a day filled with insightful discussions and advancements in the validation of methods for the characterization of endocrine disruptors. Organized by the PEPPER platform for its 5th anniversary, this event will be held in both French and English, available in-person and online. 🎧🌐 Registrations opening soon. 🔜 𝗞𝗲𝘆 𝘁𝗵𝗲𝗺𝗲𝘀: • Organizing validation in Europe: Hear from the OECD, EU bodies, member states, and stakeholders as they share progress and approaches. • Translating research into tools: Field experts will share their experiences and expectations in method development. • Sustaining validation as a common good: A collective effort towards organizing and funding validation for faster progress. Since 2019, the Pepper platform has been innovating by combining public and private resources to accelerate method validation. It aims to act as a catalyst for protecting populations and the environment from endocrine disruptors by bridging the gap between fundamental research and practical applications. 🔗 Join us in making this event a success and advancing our shared goals of protection and innovation! More info : [email protected] #PepperColloquium #EndocrineDisruptors #Innovation #Health #Environment #Research #MethodValidation #events

📣 “𝗡𝗲𝘂𝗿𝗶𝘁𝗲 𝗼𝘂𝘁𝗴𝗿𝗼𝘄𝘁𝗵-𝗡𝗲𝘂𝗿𝗼𝗻𝗮𝗹 𝗱𝗶𝗳𝗳𝗲𝗿𝗲𝗻𝘁𝗶𝗮𝘁𝗶𝗼𝗻 𝗼𝗳 𝗖17.2 𝗶𝗻 𝗿𝗲𝘀𝗽𝗼𝗻𝘀𝗲 𝘁𝗼 𝗥𝗔𝗥, 𝗥𝗫𝗥 𝗮𝗻𝗱 𝗣𝗣𝗔𝗥δ” 𝗺𝗲𝘁𝗵𝗼𝗱 ---- 🇬🇧 We are glad to announce and 𝗰𝗼𝗻𝗴𝗿𝗮𝘁𝘂𝗹𝗮𝘁𝗲 𝘁𝗵𝗲 𝘁𝘄𝗼 𝗹𝗮𝗯𝗼𝗿𝗮𝘁𝗼𝗿𝗶𝗲𝘀 𝘀𝗲𝗹𝗲𝗰𝘁𝗲𝗱 to collaborate on the validation of an innovative in vitro method 𝗱𝗲𝘃𝗲𝗹𝗼𝗽𝗲𝗱 𝗮𝘁 Uppsala University (Sweden): Bionos Biotech S.L. and 𝗨𝗻𝗶𝘁𝗲𝗱 𝗞𝗶𝗻𝗴𝗱𝗼𝗺 𝗛𝗲𝗮𝗹𝘁𝗵 𝗦𝗲𝗰𝘂𝗿𝗶𝘁𝘆 𝗔𝗴𝗲𝗻𝗰𝘆 (UKHSA) This cutting-edge research uses murine neuroprogenitor cells (C17.2), whose neuronal differentiation and neurite morphology are dependent on the hormonal environment in which they evolve. These parameters will be studied through immunofluorescence using microscopy and high-content imaging. The objective? To determine the robustness of this test with reference chemicals acting via two key endocrine pathways: retinoids and PPARδ. ---- 🇫🇷 Nous sommes heureux d'annoncer et de 𝗳é𝗹𝗶𝗰𝗶𝘁𝗲𝗿 𝗹𝗲𝘀 𝗱𝗲𝘂𝘅 𝗹𝗮𝗯𝗼𝗿𝗮𝘁𝗼𝗶𝗿𝗲𝘀 𝘀é𝗹𝗲𝗰𝘁𝗶𝗼𝗻𝗻é𝘀 𝗽𝗼𝘂𝗿 𝗰𝗼𝗹𝗹𝗮𝗯𝗼𝗿𝗲𝗿 à 𝗹𝗮 𝘃𝗮𝗹𝗶𝗱𝗮𝘁𝗶𝗼𝗻 𝗱'𝘂𝗻𝗲 𝗺é𝘁𝗵𝗼𝗱𝗲 𝗶𝗻 𝘃𝗶𝘁𝗿𝗼 𝗶𝗻𝗻𝗼𝘃𝗮𝗻𝘁𝗲 𝗱é𝘃𝗲𝗹𝗼𝗽𝗽é𝗲 à 𝗹'Uppsala University (Suède) : Bionos Biotech S.L. et 𝗨𝗻𝗶𝘁𝗲𝗱 𝗞𝗶𝗻𝗴𝗱𝗼𝗺 𝗛𝗲𝗮𝗹𝘁𝗵 𝗦𝗲𝗰𝘂𝗿𝗶𝘁𝘆 𝗔𝗴𝗲𝗻𝗰𝘆 (UKHSA) Cette recherche de pointe utilise des cellules neuroprogénitrices murines (C17.2) dont la différenciation neuronale et la morphologie des neurites est dépendante de l'environnement hormonal dans lequel elles évoluent. Ces paramètres seront étudiés par immunofluorescence en utilisant de la microscopie et de l' imagerie à haut contenu. L'objectif ? Déterminer la robustesse de ce test avec des produits de références agissant via deux voies endocriniennes clés : les rétinoïdes et PPARδ #Neuroscience #validation #methodvalidation #endocrinedisruptors #perturbateurendocriniens #nams #3rs #newapproadmethods #edPepper #Pepper #invitroresearch

🇫🇷  📅 𝗦𝗔𝗩𝗘 𝗧𝗛𝗘 𝗗𝗔𝗧𝗘 - 6 décembre 2024, Paris 𝗖𝗼𝗹𝗹𝗼𝗾𝘂𝗲 𝗣𝗘𝗣𝗣𝗘𝗥 - 𝗣𝗲𝗿𝘁𝘂𝗿𝗯𝗮𝘁𝗲𝘂𝗿𝘀 𝗲𝗻𝗱𝗼𝗰𝗿𝗶𝗻𝗶𝗲𝗻𝘀 : 𝗮𝗰𝗰é𝗹é𝗿𝗼𝗻𝘀 𝗲𝗻𝘀𝗲𝗺𝗯𝗹𝗲 𝗹𝗮 𝘃𝗮𝗹𝗶𝗱𝗮𝘁𝗶𝗼𝗻 𝗱𝗲𝘀 𝗺é𝘁𝗵𝗼𝗱𝗲𝘀 𝗽𝗼𝘂𝗿 𝗺𝗶𝗲𝘂𝘅 𝗻𝗼𝘂𝘀 𝗽𝗿𝗼𝘁é𝗴𝗲r 🔬 Nous vous donnons rendez-vous à l'𝘌𝘴𝘱𝘢𝘤𝘦 𝘥𝘶 𝘊𝘦𝘯𝘵𝘦𝘯𝘢𝘪𝘳𝘦, 𝘔𝘢𝘪𝘴𝘰𝘯 𝘥𝘦 𝘭𝘢 𝘙𝘈𝘛𝘗, 𝘗𝘢𝘳𝘪𝘴 12𝘦, pour une journée riche en échanges et avancées sur la validation des méthodes de caractérisation des perturbateurs endocriniens. Cet événement, organisé par la plateforme PEPPER à l’occasion de ses 5 ans, sera en français et en anglais, accessible sur place ou en ligne. 🎧🌐 Inscriptions ouvertes prochainement. 🔜 Thématiques clés : • Organisation de la validation en Europe : échanges avec l’OCDE, les instances de l'UE, les États membres et les parties prenantes sur leurs avancées. • De la recherche aux outils : témoignages des acteurs de terrain sur les expériences et attentes dans l’utilisation de ces méthodes. • Pérenniser la validation comme bien commun : réflexion sur la mutualisation des ressources et du financement pour accélérer les progrès. Depuis 2019, la plateforme PEPPER innove en rassemblant des financements publics et privés pour accélérer la validation des méthodes de test. Elle se positionne comme un accélérateur pour la protection de la population et de l’environnement contre les perturbateurs endocriniens, reliant la recherche fondamentale aux applications concrètes. 🔗 Rejoignez-nous nombreux pour faire de cet événement un succès et contribuer à la protection de tous ! 𝗽𝗹𝘂𝘀 𝗱’𝗶𝗻𝗳𝗼 : [email protected] #ColloquePEPPER #PerturbateursEndocriniens #Innovation #Santé #Environnement #Recherche #Validation 

👀 Un rendez-vous à ne pas manquer pour tous les amoureux de la science et les esprits curieux comme nous! 🔭✨ Nuit Européenne des Chercheurs 2024 : Explorez la Science sous un Nouveau Jour ! ✨🔬 🗓 Quand ? Le vendredi 27 septembre, à partir de 18h00 📍 Où ? Dans plus de 300 villes à travers la France et l'Europe ! 🌍👩🔬👨🔬 Que vous soyez amateur ou expert, plongez au cœur des dernières découvertes en astronomie, médecine, biologie, environnement et bien plus encore. Chaque atelier est conçu pour éveiller la curiosité, échanger et s'émerveiller ensemble ! 🎉 Entrée libre et gratuite – 👉 En savoir plus et trouver un événement près de chez vous : https://lnkd.in/dNCgh3x5 #NuitDesChercheurs #SciencePourTous #Curiosité #Recherche #Éducation -------------------------------- 🇬🇧 ENG An event not to be missed for all science lovers and innovation enthusiasts! 🔭✨ European Researchers' Night 2024: Explore Science in a New Light! ✨🔬 🗓 When? Friday, September 27th, starting at 6:00 PM 📍Where? In more than 300 cities across France and Europe!   🌍👩🔬👨🔬 Whether you're an amateur or an expert, dive into the latest discoveries in astronomy, medicine, biology, environment, and much more.   Every workshop is designed to spark curiosity, foster exchanges, and inspire wonder together!   🎉 Free and open entry 👉 Learn more and find an event near you: https://lnkd.in/dNCgh3x5 #EuropeanResearchersNight #ScienceForAll #Curiosity #Research #Education

𝗖𝗔𝗟𝗟 𝗙𝗢𝗥 𝗠𝗘𝗧𝗛𝗢𝗗𝗦 𝗦𝗨𝗕𝗠𝗜𝗦𝗦𝗜𝗢𝗡𝗦 2024 Every year Pepper selects 𝘁𝗲𝘀𝘁 𝗺𝗲𝘁𝗵𝗼𝗱𝘀 𝗼𝗻 𝗲𝗻𝗱𝗼𝗰𝗿𝗶𝗻𝗲 𝗱𝗶𝘀𝗿𝘂𝗽𝘁𝗶𝗼𝗻, with a high level of technological maturity, developed by private or public laboratories, for which it will support validation. This action aims to diminish the lack of validated methods. 𝗠𝗲𝘁𝗵𝗼𝗱𝘀 𝗺𝘂𝘀𝘁 𝗺𝗲𝗲𝘁 𝘁𝗵𝗲 𝗳𝗼𝗹𝗹𝗼𝘄𝗶𝗻𝗴 𝗰𝗿𝗶𝘁𝗲𝗿𝗶𝗮: • 𝘮𝘢𝘵𝘶𝘳𝘪𝘵𝘺 (i.e. solid written protocol, sufficient data, see ReadEDtest https://lnkd.in/gWnj7FgC ) • 𝘦𝘹𝘱𝘦𝘤𝘵𝘢𝘵𝘪𝘰𝘯𝘴 𝘰𝘧 𝘳𝘦𝘨𝘶𝘭𝘢𝘵𝘰𝘳𝘺 𝘪𝘯𝘴𝘵𝘪𝘵𝘶𝘵𝘪𝘰𝘯𝘴 (e.g. modes of action with no tests available today) • 𝘪𝘯𝘵𝘦𝘨𝘳𝘢𝘵𝘪𝘰𝘯 𝘪𝘯𝘵𝘰 𝘢𝘯 𝘢𝘴𝘴𝘦𝘴𝘴𝘮𝘦𝘯𝘵 𝘴𝘵𝘳𝘢𝘵𝘦𝘨𝘺;  • good potential for 𝘥𝘪𝘴𝘴𝘦𝘮𝘪𝘯𝘢𝘵𝘪𝘰𝘯 in laboratories • absence of logistical or legal obstacles. NB: In silico methods, methods that are not part of the 3R framework, that are already being validated or that replicate methods that have already been validated, are not eligible. The Relevance Committee selects methods in October each year, so submissions must reach Pepper by 27 𝗦𝗲𝗽𝘁𝗲𝗺𝗯𝗲𝗿 𝗮𝘁 𝘁𝗵𝗲 𝗹𝗮𝘁𝗲𝘀𝘁. Submissions should be made using this form : https://lnkd.in/e9iK6Rje #validation #methodvalidation #endocrinedisruptors #perturbateurendocriniens #nams #3rs #newapproadmethods #edPepper #Pepper

👀 Check out our last 'NewsPepper' to stay at the forefront of the critical developments in the identification of endocrine disruptors: https://lnkd.in/e-ZTWEUE 📨 Subscribe to be sure to get the next one >  Send an email to [email protected]

Appel à Candidatures - Prix Descroix-Vernier EthicScience 2025 🚀 Le Prix DVES, doté de 110 000 euros, récompense en 3 catégories les recherches alternatives à l’expérimentation animale. 📅 Candidatures ouvertes jusqu'au 30 août 2024 ! Plus d'informations: https://lnkd.in/eUwN8ycN #RechercheÉthique #NAMs

CALL FOR METHODS SUBMISSIONS _ 2024 Every year Pepper selects test methods on endocrine disruption, with a high level of technological maturity, developed by private or public laboratories, for which it will support validation. This action aims to diminish the lack of validated methods.  Methods must meet the following criteria: maturity (i.e. solid written protocol, sufficient data, see ReadEDtest https://lnkd.in/gWnj7FgC ); expectations of regulatory institutions (e.g. modes of action with no tests available today); integration into an assessment strategy; good potential for dissemination in laboratories; absence of logistical or legal obstacles. In silico methods, methods that are not part of the 3R framework, that are already being validated or that replicate methods that have already been validated, are not eligible. The Relevance Committee selects methods in October each year, so submissions must reach Pepper by 31 August at the latest. Submissions should be made using the form below

Prepare to join the 23 partner laboratories engaged in validating methods for the characterization of #endocrinedisruptors Pepper issues a call for “testing laboratories” for the #validation of “Fluorescent FITC-T4 Transthyretin Competitive Binding Assay for endocrine disruptors” To apply, send your offer before the 31st of July, following the instructions on the attached document, to [email protected] and to [email protected] If you have questions, please do not hesitate to contact us!

🇬🇧 The identification of endocrine disruptors is improving. To stay at the forefront of these critical developments subscribe to the Pepper Newsletter by sending an email to [email protected]   🇫🇷 La caractérisation des perturbateurs endocriniens s’améliore sans cesse. Pour rester au courant de ces développements cruciaux, abonnez-vous à la newsletter de Pepper en envoyant un email [email protected]