SETD7

SETD7
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	1H3I, 1MT6, 1MUF, 1N6A, 1N6C, 1O9S, 1XQH, 2F69, 3CBM, 3CBO, 3CBP, 3M53, 3M54, 3M55, 3M56, 3M57, 3M58, 3M59, 3M5A, 3OS5, 3VUZ, 3VV0, 4E47, 4J7F, 4J8O, 4JDS, 4JLG, 5EG2, 5AYF
معین‌کننده‌ها
نام‌های دیگر	SETD7, KMT7, SET7, SET7/9, SET9, SET domain containing lysine methyltransferase 7, SET domain containing 7, histone lysine methyltransferase
شناسه‌های بیرونی	OMIM: 606863 MGI: 1920501 HomoloGene: 12741 GeneCards: SETD7
موقعیت ژن (موش)
کروموزوم	کروموزوم ۳ (موش)
پایان	51,468,300 bp
الگوی گسترش RNA
	; ;
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• GO:0102674، GO:0102675 methyltransferase activity; • transferase activity; • p53 binding; • chromatin binding; • protein-lysine N-methyltransferase activity; • GO:0001948، GO:0016582 پیوند پروتئینی; • histone-lysine N-methyltransferase activity;
ترکیبات سلولی	• نوکلئوپلاسم; • کروموزوم; • هستک; • هسته یاخته;
فرایند زیستی	• GO:0009373 regulation of transcription, DNA-templated; • peptidyl-lysine monomethylation; • transcription, DNA-templated; • cellular response to DNA damage stimulus; • GO:0060469، GO:0009371 positive regulation of transcription, DNA-templated; • peptidyl-lysine methylation; • متیل‌دار کردن; • heterochromatin organization; • peptidyl-lysine dimethylation; • histone lysine methylation; • response to ethanol; • regulation of histone H3-K9 methylation; • GO:0031497، GO:0006336، GO:0034724، GO:0001301، GO:0007580، GO:0034652، GO:0010847 chromatin organization;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	80854
	73251
	ENSG00000145391
	ENSMUSG00000037111
	Q8WTS6
	Q8VHL1
	NM_001306200، NM_030648، NR_131339، XM_017008661 NM_001306199، NM_001306200، NM_030648، NR_131339، XM_017008661
	XM_036163353، XR_004941406 NM_080793، XM_036163353، XR_004941406
	NP_001293129، NP_085151، XP_016864150 NP_001293128، NP_001293129، NP_085151، XP_016864150
	XP_036019246 NP_542983، XP_036019246
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

هیستون-لیزین ان-متیل‌ترانسفراز SETD7 (انگلیسی: Histone-lysine N-methyltransferase SETD7) یک آنزیم است که در انسان توسط ژن «SETD7» کُدگذاری می‌شود.^[۴]^[۵]^[۶]

منابع

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000037111 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Nishioka K, Chuikov S, Sarma K, Erdjument-Bromage H, Allis CD, Tempst P, Reinberg D (Feb 2002). "Set9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for heterochromatin formation". Genes Dev. 16 (4): 479–89. doi:10.1101/gad.967202. PMC 155346. PMID 11850410.
↑ Wang H, Cao R, Xia L, Erdjument-Bromage H, Borchers C, Tempst P, Zhang Y (Jan 2002). "Purification and functional characterization of a histone H3-lysine 4-specific methyltransferase". Mol Cell. 8 (6): 1207–17. doi:10.1016/S1097-2765(01)00405-1. PMID 11779497.
↑ "Entrez Gene: SETD7 SET domain containing (lysine methyltransferase) 7".

مشارکت‌کنندگان ویکی‌پدیا. «SETD7». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۱ اکتبر ۲۰۱۹.

برای مطالعهٔ بیشتر

Nagase T, Kikuno R, Hattori A, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970.
Wilson JR, Jing C, Walker PA, et al. (2002). "Crystal structure and functional analysis of the histone methyltransferase SET7/9". Cell. 111 (1): 105–15. doi:10.1016/S0092-8674(02)00964-9. PMID 12372304.
Jacobs SA, Harp JM, Devarakonda S, et al. (2002). "The active site of the SET domain is constructed on a knot". Nat. Struct. Biol. 9 (11): 833–8. doi:10.1038/nsb861. PMID 12389038.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Kwon T, Chang JH, Kwak E, et al. (2003). "Mechanism of histone lysine methyl transfer revealed by the structure of SET7/9–AdoMet". EMBO J. 22 (2): 292–303. doi:10.1093/emboj/cdg025. PMC 140100. PMID 12514135.
Xiao B, Jing C, Wilson JR, et al. (2003). "Structure and catalytic mechanism of the human histone methyltransferase SET7/9" (PDF). Nature. 421 (6923): 652–6. doi:10.1038/nature01378. PMID 12540855.
Wysocka J, Myers MP, Laherty CD, et al. (2003). "Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1". Genes Dev. 17 (7): 896–911. doi:10.1101/gad.252103. PMC 196026. PMID 12670868.
Kouskouti A, Scheer E, Staub A, et al. (2004). "Gene-specific modulation of TAF10 function by SET9-mediated methylation". Mol. Cell. 14 (2): 175–82. doi:10.1016/S1097-2765(04)00182-0. PMID 15099517.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Chuikov S, Kurash JK, Wilson JR, et al. (2004). "Regulation of p53 activity through lysine methylation". Nature. 432 (7015): 353–60. doi:10.1038/nature03117. PMID 15525938.
Couture JF, Collazo E, Hauk G, Trievel RC (2006). "Structural basis for the methylation site specificity of SET7/9". Nat. Struct. Mol. Biol. 13 (2): 140–6. doi:10.1038/nsmb1045. PMID 16415881.
Hayakawa T, Ohtani Y, Hayakawa N, et al. (2007). "RBP2 is an MRG15 complex component and down-regulates intragenic histone H3 lysine 4 methylation". Genes Cells. 12 (6): 811–26. doi:10.1111/j.1365-2443.2007.01089.x. PMID 17573780.

این یک مقالهٔ خرد زیست‌شناسی مولکولی است. می‌توانید با گسترش آن به ویکی‌پدیا کمک کنید.

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000037111 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11850410-4] Nishioka K, Chuikov S, Sarma K, Erdjument-Bromage H, Allis CD, Tempst P, Reinberg D (Feb 2002). "Set9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for heterochromatin formation". Genes Dev. 16 (4): 479–89. doi:10.1101/gad.967202. PMC 155346. PMID 11850410.

[pmid11779497-5] Wang H, Cao R, Xia L, Erdjument-Bromage H, Borchers C, Tempst P, Zhang Y (Jan 2002). "Purification and functional characterization of a histone H3-lysine 4-specific methyltransferase". Mol Cell. 8 (6): 1207–17. doi:10.1016/S1097-2765(01)00405-1. PMID 11779497.

[entrez-6] "Entrez Gene: SETD7 SET domain containing (lysine methyltransferase) 7".

[۱]

[۲]

[۳]

[۴]

[۵]

[۶]