RFXANK
ظاهر
پروتئین RFXANK متصلشونده به دیانای (انگلیسی: DNA-binding protein RFXANK) یک پروتئین است که در انسان توسط ژن «RFXANK» کُدگذاری میشود.[۴][۵][۶]
این پروتئین در بیان ژن مجموعه سازگاری بافتی اصلی کلاس دو (MHC class II) نقش دارد که از اجزاء مهم دستگاه ایمنی بدن هستند.
دو نسخهٔ رونویسی متفاوت از این ژن شناسایی شدهاست که ایزوفرمهای متفاوتی از پروتئین را کدگذاری میکنند که تنها یکی از این دو ایزوفرم، نقش «فعالکننده» دارند.[۶]
منابع
[ویرایش]- ↑ ۱٫۰ ۱٫۱ ۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000036120 - Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ Masternak K, Barras E, Zufferey M, Conrad B, Corthals G, Aebersold R, Sanchez JC, Hochstrasser DF, Mach B, Reith W (Nov 1998). "A gene encoding a novel RFX-associated transactivator is mutated in the majority of MHC class II deficiency patients". Nature Genetics. 20 (3): 273–7. doi:10.1038/3081. PMID 9806546.
- ↑ Nagarajan UM, Louis-Plence P, DeSandro A, Nilsen R, Bushey A, Boss JM (Feb 1999). "RFX-B is the gene responsible for the most common cause of the bare lymphocyte syndrome, an MHC class II immunodeficiency". Immunity. 10 (2): 153–62. doi:10.1016/S1074-7613(00)80016-3. PMID 10072068.
- ↑ ۶٫۰ ۶٫۱ "Entrez Gene: RFXANK regulatory factor X-associated ankyrin-containing protein".
- مشارکتکنندگان ویکیپدیا. «RFXANK». در دانشنامهٔ ویکیپدیای انگلیسی، بازبینیشده در ۱۶ مارس ۲۰۲۰.
برای مطالعهٔ بیشتر
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