INSL3
ظاهر
شبه انسولین ۳ (انگلیسی: Insulin-like 3) یک پروتئین است که در انسان توسط ژن «INSL3» کُدگذاری میشود.[۴][۵]
پروتئینی که توسط این ژن کُدگذاری میشود یک هورمون شبه انسولینی است که بیشتر توسط غدد جنسی مردان و زنان ساخته میشود. مطالعات آزمایشگاهی بر روی موش نشان میدهد که این ژن ممکن است در تکامل دستگاه ادراری-تناسلی و باروری زنان نقش داشته باشد. جهش در این ژن ممکن است منجر به نهانبیضگی شود، اما دلیل شایعی برای آن نیست.[۵]
منابع
[ویرایش]- ↑ ۱٫۰ ۱٫۱ ۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000079019 - Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ Burkhardt E, Adham IM, Brosig B, Gastmann A, Mattei MG, Engel W (March 1994). "Structural organization of the porcine and human genes coding for a Leydig cell-specific insulin-like peptide (LEY I-L) and chromosomal localization of the human gene (INSL3)". Genomics. 20 (1): 13–9. doi:10.1006/geno.1994.1121. PMID 8020942.
- ↑ ۵٫۰ ۵٫۱ "Entrez Gene: INSL3 insulin-like 3 (Leydig cell)".
برای مطالعهٔ بیشتر
[ویرایش]- Lai KS, Jin Y, Graham DK, Witthuhn BA, Ihle JN, Liu ET (October 1995). "A kinase-deficient splice variant of the human JAK3 is expressed in hematopoietic and epithelial cancer cells". The Journal of Biological Chemistry. 270 (42): 25028–36. doi:10.1074/jbc.270.42.25028. PMID 7559633.
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- Nef S, Parada LF (July 1999). "Cryptorchidism in mice mutant for Insl3". Nature Genetics. 22 (3): 295–9. doi:10.1038/10364. PMID 10391220. S2CID 1394181.
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- Krausz C, Quintana-Murci L, Fellous M, Siffroi JP, McElreavey K (April 2000). "Absence of mutations involving the INSL3 gene in human idiopathic cryptorchidism". Molecular Human Reproduction. 6 (4): 298–302. doi:10.1093/molehr/6.4.298. PMID 10729310.
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- Hombach-Klonisch S, Buchmann J, Sarun S, Fischer B, Klonisch T (December 2000). "Relaxin-like factor (RLF) is differentially expressed in the normal and neoplastic human mammary gland". Cancer. 89 (11): 2161–8. doi:10.1002/1097-0142(20001201)89:11<2161::AID-CNCR3>3.0.CO;2-K. PMID 11147585.
- Lim HN, Raipert-de Meyts E, Skakkebaek NE, Hawkins JR, Hughes IA (February 2001). "Genetic analysis of the INSL3 gene in patients with maldescent of the testis". European Journal of Endocrinology. 144 (2): 129–37. doi:10.1530/eje.0.1440129. PMID 11182749.