HDAC4

HDAC4
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	2H8N, 2O94, 2VQJ, 2VQM, 2VQO, 2VQQ, 2VQV, 2VQW, 3UXG, 3UZD, 3V31, 4CBT, 4CBY, 5A2S
معین‌کننده‌ها
نام‌های دیگر	HDAC4, AHO3, BDMR, HA6116, HD4, HDAC-4, HDAC-A, HDACA, histone deacetylase 4, NEDCHID
شناسه‌های بیرونی	OMIM: 605314 MGI: 3036234 HomoloGene: 58636 GeneCards: HDAC4
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱ (موش)
پایان	92,123,421 bp
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• NAD-dependent histone deacetylase activity (H3-K14 specific); • sequence-specific DNA binding; • DNA binding; • GO:0001106 transcription corepressor activity; • histone deacetylase activity; • zinc ion binding; • transcription factor binding; • histone deacetylase binding; • potassium ion binding; • chromatin binding; • metal ion binding; • GO:0001948، GO:0016582 پیوند پروتئینی; • protein kinase binding; • hydrolase activity; • protein deacetylase activity; • identical protein binding; • promoter-specific chromatin binding; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • SUMO transferase activity;
ترکیبات سلولی	• سیتوپلاسم; • histone deacetylase complex; • تماس عصبی-ماهیچه‌ای; • transcription repressor complex; • سارکومر; • Z discdkac; • A band; • actomyosin; • هسته یاخته; • سیتوزول; • نوکلئوپلاسم; • GO:0009327 protein-containing complex;
فرایند زیستی	• positive regulation of reactive oxygen species biosynthetic process; • histone H3 deacetylation; • skeletal system development; • chromatin remodeling; • peptidyl-lysine deacetylation; • regulation of cardiac muscle contraction by calcium ion signaling; • negative regulation of glycolytic process; • response to interleukin-1; • GO:0009373 regulation of transcription, DNA-templated; • regulation of gene expression, epigenetic; • cellular response to tumor necrosis factor; • positive regulation of DNA-binding transcription factor activity; • GO:1901227 negative regulation of transcription by RNA polymerase II; • positive regulation of protein sumoylation; • negative regulation of DNA-binding transcription factor activity; • negative regulation of osteoblast differentiation; • transcription, DNA-templated; • جنین‌شناسی دستگاه عصبی مرکزی; • regulation of striated muscle cell differentiation; • GO:0060469، GO:0009371 positive regulation of transcription, DNA-templated; • positive regulation of smooth muscle cell migration; • B cell activation; • histone H4 deacetylation; • cellular response to mechanical stimulus; • positive regulation of neuron apoptotic process; • cardiac muscle hypertrophy in response to stress; • positive regulation of cell population proliferation; • negative regulation of myotube differentiation; • response to denervation involved in regulation of muscle adaptation; • regulation of skeletal muscle fiber development; • osteoblast development; • B cell differentiation; • cellular response to parathyroid hormone stimulus; • inflammatory response; • positive regulation of lamellipodium assembly; • regulation of protein binding; • GO:0045996 negative regulation of transcription, DNA-templated; • histone deacetylation; • GO:0003257، GO:0010735، GO:1901228، GO:1900622، GO:1904488 positive regulation of transcription by RNA polymerase II; • negative regulation of cell population proliferation; • positive regulation of smooth muscle cell proliferation; • GO:0031497، GO:0006336، GO:0034724، GO:0001301، GO:0007580، GO:0034652، GO:0010847 chromatin organization; • negative regulation of pri-miRNA transcription by RNA polymerase II; • protein deacetylation; • protein sumoylation; • positive regulation of male mating behavior;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	9759
	208727
	ENSG00000068024
	ENSMUSG00000026313
	P56524
	Q6NZM9
	NM_006037، XM_006712877، XM_006712879، XM_006712880، XM_011512217، XM_011512218، XM_011512219، XM_011512220، XM_011512222، XM_011512223، XM_011512224، XM_011512225، XM_011512226، XM_011512227، XM_017005394، XM_017005395، XM_024453257، NM_001378414، NM_001378415، NM_001378416، NM_001378417 XM_011512230، NM_006037، XM_006712877، XM_006712879، XM_006712880، XM_011512217، XM_011512218، XM_011512219، XM_011512220، XM_011512222، XM_011512223، XM_011512224، XM_011512225، XM_011512226، XM_011512227، XM_017005394، XM_017005395، XM_024453257، NM_001378414، NM_001378415، NM_001378416، NM_001378417
	XM_006529311، XM_006529312، XM_006529313، XM_006529314، XM_006529315، XM_017319476، XM_017319477، XM_017319478، XM_017319479، XM_017319480، XM_017319482، XM_017319486، XM_017319487، XM_017319488، XM_017319498، XM_017319501، XM_030252529، XM_030252531، XM_030252541، XM_030252549، XM_030252550، XM_030252552، XM_036163125، XM_036163131 NM_207225، XM_006529311، XM_006529312، XM_006529313، XM_006529314، XM_006529315، XM_017319476، XM_017319477، XM_017319478، XM_017319479، XM_017319480، XM_017319482، XM_017319486، XM_017319487، XM_017319488، XM_017319498، XM_017319501، XM_030252529، XM_030252531، XM_030252541، XM_030252549، XM_030252550، XM_030252552، XM_036163125، XM_036163131
	XP_006712940، XP_006712942، XP_006712943، XP_011510519، XP_011510520، XP_011510521، XP_011510522، XP_011510524، XP_011510525، XP_011510526، XP_011510527، XP_011510528، XP_011510529، XP_011510532، XP_016860883، XP_016860884، XP_024309025، NP_001365343، NP_001365344، NP_001365345، NP_001365346 NP_006028، XP_006712940، XP_006712942، XP_006712943، XP_011510519، XP_011510520، XP_011510521، XP_011510522، XP_011510524، XP_011510525، XP_011510526، XP_011510527، XP_011510528، XP_011510529، XP_011510532، XP_016860883، XP_016860884، XP_024309025، NP_001365343، NP_001365344، NP_001365345، NP_001365346
	XP_006529374، XP_006529375، XP_006529376، XP_006529377، XP_006529378، XP_017174965، XP_017174966، XP_017174967، XP_017174968، XP_017174969، XP_017174971، XP_017174975، XP_017174976، XP_017174977، XP_017174987، XP_017174990، XP_030108389، XP_030108391، XP_030108401، XP_030108409، XP_030108410، XP_030108412، XP_036019018، XP_036019024 NP_997108، XP_006529374، XP_006529375، XP_006529376، XP_006529377، XP_006529378، XP_017174965، XP_017174966، XP_017174967، XP_017174968، XP_017174969، XP_017174971، XP_017174975، XP_017174976، XP_017174977، XP_017174987، XP_017174990، XP_030108389، XP_030108391، XP_030108401، XP_030108409، XP_030108410، XP_030108412، XP_036019018، XP_036019024
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

هیستون دِاَستیلاز ۴ (انگلیسی: Histone deacetylase 4) یک پروتئین است که در انسان توسط ژن «HDAC4» کُدگذاری می‌شود.^[۴]^[۵]

این پروتئین نقش بسیار مهمی در تنظیم رونویسی ژن‌ها، پیشرفتِ چرخهٔ سلولی و وقایع تکاملی سلول دارد.

هیستون دِاَستیلاز ۹، با مولکول HDAC3^[۴]^[۶]^[۷]^[۸] و ZBTB16^[۹]^[۱۰] تعامل پروتئین-پروتئین دارد.

اهمیت بالینی

پژوهش‌ها نشان داده‌اند که هیستون دِاَستیلاز ۴ در رشد و تکامل استخوان و ماهیچه نقش دارد.

همچنین پژوهشگران دانشگاه هاروارد به این نتیجه رسیده‌اند که این آنزیم در سلامت قوهٔ بینایی نقش دارد: کاهش سطح این آنزیم موجب مرگ گیرنده‌های استوانه‌ای‌شکل و سلول‌های دوقطبی شبکیه در موش‌ها می‌گردد.^[۱۱]^[۱۲]

منابع

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000026313 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ ^۴٫۰ ^۴٫۱ Grozinger CM, Hassig CA, Schreiber SL (April 1999). "Three proteins define a class of human histone deacetylases related to yeast Hda1p". Proceedings of the National Academy of Sciences of the United States of America. 96 (9): 4868–73. doi:10.1073/pnas.96.9.4868. PMC 21783. PMID 10220385.
↑ Fischle W, Emiliani S, Hendzel MJ, Nagase T, Nomura N, Voelter W, Verdin E (April 1999). "A new family of human histone deacetylases related to Saccharomyces cerevisiae HDA1p". The Journal of Biological Chemistry. 274 (17): 11713–20. doi:10.1074/jbc.274.17.11713. PMID 10206986.
↑ Fischle W, Dequiedt F, Hendzel MJ, Guenther MG, Lazar MA, Voelter W, Verdin E (January 2002). "Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR". Molecular Cell. 9 (1): 45–57. doi:10.1016/s1097-2765(01)00429-4. PMID 11804585.
↑ Grozinger CM, Schreiber SL (July 2000). "Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization". Proceedings of the National Academy of Sciences of the United States of America. 97 (14): 7835–40. doi:10.1073/pnas.140199597. PMC 16631. PMID 10869435.
↑ Fischle W, Dequiedt F, Fillion M, Hendzel MJ, Voelter W, Verdin E (September 2001). "Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo". The Journal of Biological Chemistry. 276 (38): 35826–35. doi:10.1074/jbc.M104935200. PMID 11466315.
↑ Lemercier C, Brocard MP, Puvion-Dutilleul F, Kao HY, Albagli O, Khochbin S (June 2002). "Class II histone deacetylases are directly recruited by BCL6 transcriptional repressor". The Journal of Biological Chemistry. 277 (24): 22045–52. doi:10.1074/jbc.M201736200. PMID 11929873.
↑ Chauchereau A, Mathieu M, de Saintignon J, Ferreira R, Pritchard LL, Mishal Z, Dejean A, Harel-Bellan A (November 2004). "HDAC4 mediates transcriptional repression by the acute promyelocytic leukaemia-associated protein PLZF". Oncogene. 23 (54): 8777–84. doi:10.1038/sj.onc.1208128. PMID 15467736.
↑ Protein for Sight, Scientific American, 300, 3 (March 2009), p. 23
↑ Chen B, Cepko CL (January 2009). "HDAC4 regulates neuronal survival in normal and diseased retinas". Science. 323 (5911): 256–9. doi:10.1126/science.1166226. PMC 3339762. PMID 19131628.

مشارکت‌کنندگان ویکی‌پدیا. «HDAC4». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۱۰ مارس ۲۰۲۰.

برای مطالعهٔ بیشتر

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Verdin E, Dequiedt F, Kasler HG (May 2003). "Class II histone deacetylases: versatile regulators". Trends in Genetics. 19 (5): 286–93. doi:10.1016/S0168-9525(03)00073-8. PMID 12711221.
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Wolffe AP (May 1997). "Transcriptional control. Sinful repression". Nature. 387 (6628): 16–7. doi:10.1038/387016a0. PMID 9139815.
Ohara O, Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Nomura N (February 1997). "Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins". DNA Research. 4 (1): 53–9. doi:10.1093/dnares/4.1.53. PMID 9179496.
Fischle W, Emiliani S, Hendzel MJ, Nagase T, Nomura N, Voelter W, Verdin E (April 1999). "A new family of human histone deacetylases related to Saccharomyces cerevisiae HDA1p". The Journal of Biological Chemistry. 274 (17): 11713–20. doi:10.1074/jbc.274.17.11713. PMID 10206986.
Grozinger CM, Hassig CA, Schreiber SL (April 1999). "Three proteins define a class of human histone deacetylases related to yeast Hda1p". Proceedings of the National Academy of Sciences of the United States of America. 96 (9): 4868–73. doi:10.1073/pnas.96.9.4868. PMC 21783. PMID 10220385.
Miska EA, Karlsson C, Langley E, Nielsen SJ, Pines J, Kouzarides T (September 1999). "HDAC4 deacetylase associates with and represses the MEF2 transcription factor". The EMBO Journal. 18 (18): 5099–107. doi:10.1093/emboj/18.18.5099. PMC 1171580. PMID 10487761.
Wang AH, Bertos NR, Vezmar M, Pelletier N, Crosato M, Heng HH, Th'ng J, Han J, Yang XJ (November 1999). "HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor". Molecular and Cellular Biology. 19 (11): 7816–27. doi:10.1128/mcb.19.11.7816. PMC 84849. PMID 10523670.
Youn HD, Grozinger CM, Liu JO (July 2000). "Calcium regulates transcriptional repression of myocyte enhancer factor 2 by histone deacetylase 4". The Journal of Biological Chemistry. 275 (29): 22563–7. doi:10.1074/jbc.C000304200. PMID 10825153.
Grozinger CM, Schreiber SL (July 2000). "Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization". Proceedings of the National Academy of Sciences of the United States of America. 97 (14): 7835–40. doi:10.1073/pnas.140199597. PMC 16631. PMID 10869435.
Huynh KD, Fischle W, Verdin E, Bardwell VJ (July 2000). "BCoR, a novel corepressor involved in BCL-6 repression". Genes & Development. 14 (14): 1810–23. doi:10.1101/gad.14.14.1810 (inactive 2019-12-14). PMC 316791. PMID 10898795.{{cite journal}}: CS1 maint: DOI inactive as of دسامبر 2019 (link)
Li J, Wang J, Wang J, Nawaz Z, Liu JM, Qin J, Wong J (August 2000). "Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3". The EMBO Journal. 19 (16): 4342–50. doi:10.1093/emboj/19.16.4342. PMC 302030. PMID 10944117.
Wang AH, Kruhlak MJ, Wu J, Bertos NR, Vezmar M, Posner BI, Bazett-Jones DP, Yang XJ (September 2000). "Regulation of histone deacetylase 4 by binding of 14-3-3 proteins". Molecular and Cellular Biology. 20 (18): 6904–12. doi:10.1128/MCB.20.18.6904-6912.2000. PMC 88766. PMID 10958686.
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Zhou X, Richon VM, Wang AH, Yang XJ, Rifkind RA, Marks PA (December 2000). "Histone deacetylase 4 associates with extracellular signal-regulated kinases 1 and 2, and its cellular localization is regulated by oncogenic Ras". Proceedings of the National Academy of Sciences of the United States of America. 97 (26): 14329–33. doi:10.1073/pnas.250494697. PMC 18918. PMID 11114188.
McKinsey TA, Zhang CL, Olson EN (December 2000). "Activation of the myocyte enhancer factor-2 transcription factor by calcium/calmodulin-dependent protein kinase-stimulated binding of 14-3-3 to histone deacetylase 5". Proceedings of the National Academy of Sciences of the United States of America. 97 (26): 14400–5. doi:10.1073/pnas.260501497. PMC 18930. PMID 11114197.

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000026313 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10220385-4] ۴٫۰ ^۴٫۱ Grozinger CM, Hassig CA, Schreiber SL (April 1999). "Three proteins define a class of human histone deacetylases related to yeast Hda1p". Proceedings of the National Academy of Sciences of the United States of America. 96 (9): 4868–73. doi:10.1073/pnas.96.9.4868. PMC 21783. PMID 10220385.

[pmid10206986-5] Fischle W, Emiliani S, Hendzel MJ, Nagase T, Nomura N, Voelter W, Verdin E (April 1999). "A new family of human histone deacetylases related to Saccharomyces cerevisiae HDA1p". The Journal of Biological Chemistry. 274 (17): 11713–20. doi:10.1074/jbc.274.17.11713. PMID 10206986.

[pmid11804585-6] Fischle W, Dequiedt F, Hendzel MJ, Guenther MG, Lazar MA, Voelter W, Verdin E (January 2002). "Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR". Molecular Cell. 9 (1): 45–57. doi:10.1016/s1097-2765(01)00429-4. PMID 11804585.

[pmid10869435-7] Grozinger CM, Schreiber SL (July 2000). "Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization". Proceedings of the National Academy of Sciences of the United States of America. 97 (14): 7835–40. doi:10.1073/pnas.140199597. PMC 16631. PMID 10869435.

[pmid11466315-8] Fischle W, Dequiedt F, Fillion M, Hendzel MJ, Voelter W, Verdin E (September 2001). "Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo". The Journal of Biological Chemistry. 276 (38): 35826–35. doi:10.1074/jbc.M104935200. PMID 11466315.

[pmid11929873-9] Lemercier C, Brocard MP, Puvion-Dutilleul F, Kao HY, Albagli O, Khochbin S (June 2002). "Class II histone deacetylases are directly recruited by BCL6 transcriptional repressor". The Journal of Biological Chemistry. 277 (24): 22045–52. doi:10.1074/jbc.M201736200. PMID 11929873.

[pmid15467736-10] Chauchereau A, Mathieu M, de Saintignon J, Ferreira R, Pritchard LL, Mishal Z, Dejean A, Harel-Bellan A (November 2004). "HDAC4 mediates transcriptional repression by the acute promyelocytic leukaemia-associated protein PLZF". Oncogene. 23 (54): 8777–84. doi:10.1038/sj.onc.1208128. PMID 15467736.

[11] Protein for Sight, Scientific American, 300, 3 (March 2009), p. 23

[pmid19131628-12] Chen B, Cepko CL (January 2009). "HDAC4 regulates neuronal survival in normal and diseased retinas". Science. 323 (5911): 256–9. doi:10.1126/science.1166226. PMC 3339762. PMID 19131628.

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ن ب و آنزیم‌ها
فعالیت	جایگاه فعال جایگاه اتصال سه‌گانه کاتالیزگر Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme کوآنزیم کوفاکتور کاتالیز آنزیم
قواعد	دگرریختاری Cooperativity بازدارنده آنزیم فعال‌کننده آنزیم
دسته‌بندی	عدد گروه آنزیم ابرخانواده آنزیم خانواده آنزیم فهرست آنزیم‌ها
سینتیک	سینتیک میکائلیس–منتن طرح ادی هوفستی طرح لاینویور برک طرح هانس وولف
انواع	ای‌سی۱ اکسیدوردوکتازها (فهرست) ای‌سی۲ ترانسفرازها (فهرست) ای‌سی۳ هیدرولازها (فهرست) ای‌سی۴ لیازها (فهرست) ای‌سی۵ ایزومرازها (فهرست) ای‌سی۶ لیگازها (فهرست) ای‌سی۷ ترنسلوکازها (فهرست)