FYN

FYN
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	1A0N, 1AOT, 1AOU, 1AVZ, 1AZG, 1EFN, 1FYN, 1G83, 1M27, 1NYF, 1NYG, 1SHF, 1ZBJ, 2DQ7, 3H0F, 3H0H, 3H0I, 3UA6, 3UA7, 4D8D, 4EIK, 2MQI, 2MRJ, 2MRK, 4U17, 4U1P, 4ZNX
معین‌کننده‌ها
نام‌های دیگر	FYN, SLK, SYN, p59-FYN proto-oncogene, Src family tyrosine kinase
شناسه‌های بیرونی	OMIM: 137025 MGI: 95602 HomoloGene: 48068 GeneCards: FYN
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱۰ (موش)
پایان	39,565,381 bp
الگوی گسترش RNA
	; ; ; ;
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• CD4 receptor binding; • transmembrane transporter binding; • GO:0032403 protein-containing complex binding; • GO:0001948، GO:0016582 پیوند پروتئینی; • CD8 receptor binding; • kinase activity; • tubulin binding; • signaling receptor binding; • ATP binding; • protein kinase activity; • metal ion binding; • peptide hormone receptor binding; • T cell receptor binding; • transferase activity; • ephrin receptor binding; • nucleotide binding; • growth factor receptor binding; • phosphatidylinositol 3-kinase binding; • G protein-coupled receptor binding; • non-membrane spanning protein tyrosine kinase activity; • phosphatidylinositol-4,5-bisphosphate 3-kinase activity; • protein tyrosine kinase activity; • enzyme binding; • identical protein binding; • signal transducer activity; • type 5 metabotropic glutamate receptor binding; • alpha-tubulin binding; • tau protein binding; • tau-protein kinase activity; • disordered domain specific binding;
ترکیبات سلولی	• سیتوپلاسم; • membrane; • extrinsic component of cytoplasmic side of plasma membrane; • میتوکندری; • هسته یاخته; • لیپید رفت; • intracellular membrane-bounded organelle; • ریزرشته; • cell periphery; • اندوزوم; • پوسته یاخته; • سیتوزول; • GO:0097483، GO:0097481 postsynaptic density; • دندریت; • cell body; • perinuclear region of cytoplasm; • perinuclear endoplasmic reticulum; • glial cell projection; • Schaffer collateral - CA1 synapse; • glutamatergic synapse; • postsynaptic density, intracellular component;
فرایند زیستی	• GO:1904089 negative regulation of neuron apoptotic process; • adaptive immune response; • یادگیری; • platelet activation; • cell surface receptor signaling pathway; • vascular endothelial growth factor receptor signaling pathway; • رفتار تغذیه‌ای; • response to ethanol; • calcium ion transport; • regulation of apoptotic process; • cellular response to transforming growth factor beta stimulus; • Fc-gamma receptor signaling pathway involved in phagocytosis; • GO:1903363 negative regulation of protein catabolic process; • transmembrane receptor protein tyrosine kinase signaling pathway; • stimulatory C-type lectin receptor signaling pathway; • negative regulation of gene expression; • protein autophosphorylation; • T cell activation; • detection of mechanical stimulus involved in sensory perception of pain; • دگرگونی یاخته‌; • dendrite morphogenesis; • فسفرگیری; • immune system process; • neuron migration; • cellular response to platelet-derived growth factor stimulus; • regulation of cell shape; • peptidyl-tyrosine autophosphorylation; • phosphatidylinositol-mediated signaling; • leukocyte migration; • positive regulation of protein localization to nucleus; • GO:0007243 intracellular signal transduction; • activated T cell proliferation; • ephrin receptor signaling pathway; • cellular response to growth factor stimulus; • T cell costimulation; • انعقاد خون; • GO:0019049، GO:0030683 mitigation of host defenses by virus; • MAPK cascade; • هدایت آسه; • multicellular organism development; • negative regulation of protein ubiquitination; • cellular response to peptide hormone stimulus; • regulation of cell population proliferation; • positive regulation of neuron projection development; • positive regulation of I-kappaB kinase/NF-kappaB signaling; • positive regulation of phosphatidylinositol 3-kinase signaling; • peptidyl-tyrosine phosphorylation; • forebrain development; • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; • T cell receptor signaling pathway; • کوچ یاخته; • GO:0022415 viral process; • دستگاه ایمنی ذاتی; • GO:0032320، GO:0032321، GO:0032855، GO:0043089، GO:0032854 positive regulation of GTPase activity; • phosphatidylinositol phosphate biosynthetic process; • regulation of phosphatidylinositol 3-kinase signaling; • protein phosphorylation; • central nervous system development; • regulation of peptidyl-tyrosine phosphorylation; • positive regulation of protein targeting to membrane; • positive regulation of neuron death; • negative regulation of dendritic spine maintenance; • response to amyloid-beta; • regulation of calcium ion import across plasma membrane; • response to singlet oxygen; • heart process; • negative regulation of hydrogen peroxide biosynthetic process; • cytokine-mediated signaling pathway; • positive regulation of tyrosine phosphorylation of STAT protein; • response to hydrogen peroxide; • modulation of chemical synaptic transmission; • positive regulation of protein kinase B signaling; • dendritic spine maintenance; • regulation of glutamate receptor signaling pathway; • negative regulation of oxidative stress-induced cell death; • positive regulation of non-membrane spanning protein tyrosine kinase activity; • cellular response to L-glutamate; • cellular response to glycine; • positive regulation of protein localization to membrane; • positive regulation of cysteine-type endopeptidase activity; • cellular response to amyloid-beta;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	2534
	14360
	ENSG00000010810
	ENSMUSG00000019843
	P06241
	P39688
	NM_002037، NM_153047، NM_153048، XM_005266892، XM_017010650، XM_017010651، XM_017010652، XM_017010653، XM_017010655، NM_001370529 NM_001242779، NM_002037، NM_153047، NM_153048، XM_005266892، XM_017010650، XM_017010651، XM_017010652، XM_017010653، XM_017010655، NM_001370529
	NM_001122893، NM_008054، XM_006512539، XM_006512540، XM_011243117، XM_030244881 NM_001122892، NM_001122893، NM_008054، XM_006512539، XM_006512540، XM_011243117، XM_030244881
	NP_694592، NP_694593، XP_005266949، XP_016866139، XP_016866140، XP_016866141، XP_016866142، XP_016866144، NP_001357458 NP_002028، NP_694592، NP_694593، XP_005266949، XP_016866139، XP_016866140، XP_016866141، XP_016866142، XP_016866144، NP_001357458
	NP_001116365، NP_032080، XP_006512602، XP_006512603، XP_011241419، XP_030100741، XP_036011496، XP_036011497، XP_036011498، XP_036011499، XP_036011500، XP_036011501، XP_036011502، XP_036011503، XP_036011504، XP_036011505، XP_036011506، XP_036011507 NP_001116364، NP_001116365، NP_032080، XP_006512602، XP_006512603، XP_011241419، XP_030100741، XP_036011496، XP_036011497، XP_036011498، XP_036011499، XP_036011500، XP_036011501، XP_036011502، XP_036011503، XP_036011504، XP_036011505، XP_036011506، XP_036011507
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

تیروزین پروتئین کیناز پروتو-اونکوژنِ Fyn (انگلیسی: Proto-oncogene tyrosine-protein kinase Fyn) یک پروتئین است که در انسان توسط ژن «FYN» کُدگذاری می‌شود.^[۴]

این پروتئین ۵۹ کیلو دالتون وزن دارد و در سیگنالینگ یاخته‌های عصبی و لنفوسیت‌های تی در ارتباط است و هرگونه تداخل در این مسیرهای سیگنالینگ در بروز سرطان نقش دارد.

این پروتئین در تنظیم رشد سلولی نیز دخالت دارد و جهش در آن بسیاری از فرایندهای طبیعی سلولی را برهم می‌زند.^[۵]^[۶]

عملکرد

پروتئین Fyn در مسیرهای سیگنالینگ (علامت‌دهی سلولی) زیر نقش دارد:

سیگنالینگ لنفوسیت‌های تی و لنفوسیت‌های بی،^[۷]^[۸] سیگنالینگ وابسته به اینتگرین، سیگنالینگ فاکتور رشد و گیرنده سیتوکین، عملکرد مجرای یونی و فاکتور فعال‌کننده پلاکتی، چسبندگی سلولی، هدایت آکسونی، لقاح، آغاز میتوز، تمایز سلول‌های کشنده طبیعی، اولیگودندروسیت‌ها و کراتینوسیت‌ها.

اهمیت بالینی

خانوادهٔ Src کینازها، که پروتئینِ Fyn یکی از آنهاست،^[۹] از طریقِ «تهاجم و پیشرفت تومور، عبور از اپیتلیال به مزانشیمال، رگ‌زایی، و ایجاد متاستاز» در پیشرفت سرطان نقش دارند.^[۱۰]

افزایش بیش از حدِ پروتئین Fyn به‌طور شایع با سرطان‌های زیر مرتبط است:^[۵]^[۱۱]

سرطان پروستات، گلیوبلاستوما، کارسینوم سلول سنگفرشی سر و گردن، سرطان لوزالمعده، لوسمی مزمن مغز استخوان و ملانوما

تعامل‌ها

پروتئین Fyn با مولکول‌های زیر تعامل پروتئین-پروتئین دارد:

منابع

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000019843 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Semba K, Nishizawa M, Miyajima N, Yoshida MC, Sukegawa J, Yamanashi Y, Sasaki M, Yamamoto T, Toyoshima K (August 1986). "yes-related protooncogene, syn, belongs to the protein-tyrosine kinase family". Proceedings of the National Academy of Sciences of the United States of America. 83 (15): 5459–63. doi:10.1073/pnas.83.15.5459. PMC 386306. PMID 3526330.
↑ ^۵٫۰ ^۵٫۱ Saito, Yoshihito D.; Jensen, Ana R.; Salgia, Ravi; Posadas, Edwin M. (2010-04-01). "Fyn". Cancer (به انگلیسی). 116 (7): 1629–1637. doi:10.1002/cncr.24879. ISSN 1097-0142. PMC 2847065. PMID 20151426.
↑ Posadas, Edwin M.; Al-Ahmadie, Hikmat; Robinson, Victoria L.; Jagadeeswaran, Ramasamy; Otto, Kristen; Kasza, Kristen E.; Tretiakov, Maria; Siddiqui, Javed; Pienta, Kenneth J. (2009-01-01). "FYN is overexpressed in human prostate cancer". BJU International (به انگلیسی). 103 (2): 171–177. doi:10.1111/j.1464-410X.2008.08009.x. ISSN 1464-410X. PMC 2741693. PMID 18990162.
↑ Zamoyska R, Basson A, Filby A, Legname G, Lovatt M, Seddon B (February 2003). "The influence of the src-family kinases, Lck and Fyn, on T cell differentiation, survival and activation". Immunological Reviews. 191 (1): 107–18. doi:10.1034/j.1600-065X.2003.00015.x. PMID 12614355.
↑ Palacios EH, Weiss A (October 2004). "Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation". Oncogene. 23 (48): 7990–8000. doi:10.1038/sj.onc.1208074. PMID 15489916.
↑ Resh MD (November 1998). "Fyn, a Src family tyrosine kinase". The International Journal of Biochemistry & Cell Biology. 30 (11): 1159–62. doi:10.1016/S1357-2725(98)00089-2. PMID 9839441.
↑ Sen, Banibrata; Johnson, Faye M. (2011-04-04). "Regulation of Src Family Kinases in Human Cancers". Journal of Signal Transduction (به انگلیسی). 2011: 865819. doi:10.1155/2011/865819. ISSN 2090-1739. PMC 3135246. PMID 21776389.
↑ Yadav, Vipin; Denning, Mitchell F. (2011-05-01). "Fyn is induced by Ras/PI3K/Akt signaling and is required for enhanced invasion/migration". Molecular Carcinogenesis (به انگلیسی). 50 (5): 346–352. doi:10.1002/mc.20716. ISSN 1098-2744. PMC 3080437. PMID 21480388.
↑ Cleghon V, Morrison DK (July 1994). "Raf-1 interacts with Fyn and Src in a non-phosphotyrosine-dependent manner". J. Biol. Chem. 269 (26): 17749–55. PMID 7517401.
↑ Huang MM, Bolen JB, Barnwell JW, Shattil SJ, Brugge JS (September 1991). "Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human platelets". Proc. Natl. Acad. Sci. U.S.A. 88 (17): 7844–8. doi:10.1073/pnas.88.17.7844. PMC 52400. PMID 1715582.
↑ Bull HA, Brickell PM, Dowd PM (August 1994). "Src-related protein tyrosine kinases are physically associated with the surface antigen CD36 in human dermal microvascular endothelial cells". FEBS Lett. 351 (1): 41–4. doi:10.1016/0014-5793(94)00814-0. PMID 7521304.
↑ Piedra J, Miravet S, Castaño J, Pálmer HG, Heisterkamp N, García de Herreros A, Duñach M (April 2003). "p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction". Mol. Cell. Biol. 23 (7): 2287–97. doi:10.1128/mcb.23.7.2287-2297.2003. PMC 150740. PMID 12640114.
↑ Wenzel J, Sanzenbacher R, Ghadimi M, Lewitzky M, Zhou Q, Kaplan DR, Kabelitz D, Feller SM, Janssen O (December 2001). "Multiple interactions of the cytosolic polyproline region of the CD95 ligand: hints for the reverse signal transduction capacity of a death factor". FEBS Lett. 509 (2): 255–62. doi:10.1016/s0014-5793(01)03174-x. PMID 11741599.
↑ Hane M, Lowin B, Peitsch M, Becker K, Tschopp J (October 1995). "Interaction of peptides derived from the Fas ligand with the Fyn-SH3 domain". FEBS Lett. 373 (3): 265–8. doi:10.1016/0014-5793(95)01051-f. PMID 7589480.
↑ Messina S, Onofri F, Bongiorno-Borbone L, Giovedì S, Valtorta F, Girault JA, Benfenati F (January 2003). "Specific interactions of neuronal focal adhesion kinase isoforms with Src kinases and amphiphysin". J. Neurochem. 84 (2): 253–65. doi:10.1046/j.1471-4159.2003.01519.x. PMID 12558988.
↑ Arold ST, Ulmer TS, Mulhern TD, Werner JM, Ladbury JE, Campbell ID, Noble ME (May 2001). "The role of the Src homology 3-Src homology 2 interface in the regulation of Src kinases". J. Biol. Chem. 276 (20): 17199–205. doi:10.1074/jbc.M011185200. PMID 11278857.
↑ Filipp D, Moemeni B, Ferzoco A, Kathirkamathamby K, Zhang J, Ballek O, Davidson D, Veillette A, Julius M (2008). "Lck-dependent Fyn activation requires C terminus-dependent targeting of kinase-active Lck to lipid rafts". The Journal of Biological Chemistry. 283 (39): 26409–22. doi:10.1074/jbc.M710372200. PMC 3258908. PMID 18660530.
↑ Klein C, Kramer EM, Cardine AM, Schraven B, Brandt R, Trotter J (February 2002). "Process outgrowth of oligodendrocytes is promoted by interaction of fyn kinase with the cytoskeletal protein tau". J. Neurosci. 22 (3): 698–707. doi:10.1523/JNEUROSCI.22-03-00698.2002. PMID 11826099.
↑ Iwasaki Y, Gay B, Wada K, Koizumi S (July 1998). "Association of the Src family tyrosine kinase Fyn with TrkB". J. Neurochem. 71 (1): 106–11. doi:10.1046/j.1471-4159.1998.71010106.x. PMID 9648856.

مشارکت‌کنندگان ویکی‌پدیا. «FYN». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۴ اوت ۲۰۱۹.

برای مطالعهٔ بیشتر

O'Sullivan E, Kinnon C, Brickell P (1999). "Wiskott-Aldrich syndrome protein, WASP". Int. J. Biochem. Cell Biol. 31 (3–4): 383–7. doi:10.1016/S1357-2725(98)00118-6. PMID 10224664.
Sasaoka T, Kobayashi M (2000). "The functional significance of Shc in insulin signaling as a substrate of the insulin receptor". Endocr. J. 47 (4): 373–81. doi:10.1507/endocrj.47.373. PMID 11075717.
Leavitt SA, SchOn A, Klein JC, Manjappara U, Chaiken IM, Freire E (2004). "Interactions of HIV-1 proteins gp120 and Nef with cellular partners define a novel allosteric paradigm". Curr. Protein Pept. Sci. 5 (1): 1–8. doi:10.2174/1389203043486955. PMID 14965316.
Tolstrup M, Ostergaard L, Laursen AL, Pedersen SF, Duch M (2004). "HIV/SIV escape from immune surveillance: focus on Nef". Curr. HIV Res. 2 (2): 141–51. doi:10.2174/1570162043484924. PMID 15078178.
Joseph AM, Kumar M, Mitra D (2005). "Nef: "necessary and enforcing factor" in HIV infection". Curr. HIV Res. 3 (1): 87–94. doi:10.2174/1570162052773013. PMID 15638726.
Stove V, Verhasselt B (2006). "Modelling thymic HIV-1 Nef effects". Curr. HIV Res. 4 (1): 57–64. doi:10.2174/157016206775197583. PMID 16454711.

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000019843 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid3526330-4] Semba K, Nishizawa M, Miyajima N, Yoshida MC, Sukegawa J, Yamanashi Y, Sasaki M, Yamamoto T, Toyoshima K (August 1986). "yes-related protooncogene, syn, belongs to the protein-tyrosine kinase family". Proceedings of the National Academy of Sciences of the United States of America. 83 (15): 5459–63. doi:10.1073/pnas.83.15.5459. PMC 386306. PMID 3526330.

[:0-5] ۵٫۰ ^۵٫۱ Saito, Yoshihito D.; Jensen, Ana R.; Salgia, Ravi; Posadas, Edwin M. (2010-04-01). "Fyn". Cancer (به انگلیسی). 116 (7): 1629–1637. doi:10.1002/cncr.24879. ISSN 1097-0142. PMC 2847065. PMID 20151426.

[:1-6] Posadas, Edwin M.; Al-Ahmadie, Hikmat; Robinson, Victoria L.; Jagadeeswaran, Ramasamy; Otto, Kristen; Kasza, Kristen E.; Tretiakov, Maria; Siddiqui, Javed; Pienta, Kenneth J. (2009-01-01). "FYN is overexpressed in human prostate cancer". BJU International (به انگلیسی). 103 (2): 171–177. doi:10.1111/j.1464-410X.2008.08009.x. ISSN 1464-410X. PMC 2741693. PMID 18990162.

[pmid12614355-7] Zamoyska R, Basson A, Filby A, Legname G, Lovatt M, Seddon B (February 2003). "The influence of the src-family kinases, Lck and Fyn, on T cell differentiation, survival and activation". Immunological Reviews. 191 (1): 107–18. doi:10.1034/j.1600-065X.2003.00015.x. PMID 12614355.

[pmid15489916-8] Palacios EH, Weiss A (October 2004). "Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation". Oncogene. 23 (48): 7990–8000. doi:10.1038/sj.onc.1208074. PMID 15489916.

[pmid9839441-9] Resh MD (November 1998). "Fyn, a Src family tyrosine kinase". The International Journal of Biochemistry & Cell Biology. 30 (11): 1159–62. doi:10.1016/S1357-2725(98)00089-2. PMID 9839441.

[:2-10] Sen, Banibrata; Johnson, Faye M. (2011-04-04). "Regulation of Src Family Kinases in Human Cancers". Journal of Signal Transduction (به انگلیسی). 2011: 865819. doi:10.1155/2011/865819. ISSN 2090-1739. PMC 3135246. PMID 21776389.

[11] Yadav, Vipin; Denning, Mitchell F. (2011-05-01). "Fyn is induced by Ras/PI3K/Akt signaling and is required for enhanced invasion/migration". Molecular Carcinogenesis (به انگلیسی). 50 (5): 346–352. doi:10.1002/mc.20716. ISSN 1098-2744. PMC 3080437. PMID 21480388.

[pmid7517401-12] Cleghon V, Morrison DK (July 1994). "Raf-1 interacts with Fyn and Src in a non-phosphotyrosine-dependent manner". J. Biol. Chem. 269 (26): 17749–55. PMID 7517401.

[pmid1715582-13] Huang MM, Bolen JB, Barnwell JW, Shattil SJ, Brugge JS (September 1991). "Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human platelets". Proc. Natl. Acad. Sci. U.S.A. 88 (17): 7844–8. doi:10.1073/pnas.88.17.7844. PMC 52400. PMID 1715582.

[pmid7521304-14] Bull HA, Brickell PM, Dowd PM (August 1994). "Src-related protein tyrosine kinases are physically associated with the surface antigen CD36 in human dermal microvascular endothelial cells". FEBS Lett. 351 (1): 41–4. doi:10.1016/0014-5793(94)00814-0. PMID 7521304.

[pmid12640114-15] Piedra J, Miravet S, Castaño J, Pálmer HG, Heisterkamp N, García de Herreros A, Duñach M (April 2003). "p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction". Mol. Cell. Biol. 23 (7): 2287–97. doi:10.1128/mcb.23.7.2287-2297.2003. PMC 150740. PMID 12640114.

[pmid11741599-16] Wenzel J, Sanzenbacher R, Ghadimi M, Lewitzky M, Zhou Q, Kaplan DR, Kabelitz D, Feller SM, Janssen O (December 2001). "Multiple interactions of the cytosolic polyproline region of the CD95 ligand: hints for the reverse signal transduction capacity of a death factor". FEBS Lett. 509 (2): 255–62. doi:10.1016/s0014-5793(01)03174-x. PMID 11741599.

[pmid7589480-17] Hane M, Lowin B, Peitsch M, Becker K, Tschopp J (October 1995). "Interaction of peptides derived from the Fas ligand with the Fyn-SH3 domain". FEBS Lett. 373 (3): 265–8. doi:10.1016/0014-5793(95)01051-f. PMID 7589480.

[pmid12558988-18] Messina S, Onofri F, Bongiorno-Borbone L, Giovedì S, Valtorta F, Girault JA, Benfenati F (January 2003). "Specific interactions of neuronal focal adhesion kinase isoforms with Src kinases and amphiphysin". J. Neurochem. 84 (2): 253–65. doi:10.1046/j.1471-4159.2003.01519.x. PMID 12558988.

[pmid11278857-19] Arold ST, Ulmer TS, Mulhern TD, Werner JM, Ladbury JE, Campbell ID, Noble ME (May 2001). "The role of the Src homology 3-Src homology 2 interface in the regulation of Src kinases". J. Biol. Chem. 276 (20): 17199–205. doi:10.1074/jbc.M011185200. PMID 11278857.

[pmid18660530-20] Filipp D, Moemeni B, Ferzoco A, Kathirkamathamby K, Zhang J, Ballek O, Davidson D, Veillette A, Julius M (2008). "Lck-dependent Fyn activation requires C terminus-dependent targeting of kinase-active Lck to lipid rafts". The Journal of Biological Chemistry. 283 (39): 26409–22. doi:10.1074/jbc.M710372200. PMC 3258908. PMID 18660530.

[pmid11826099-21] Klein C, Kramer EM, Cardine AM, Schraven B, Brandt R, Trotter J (February 2002). "Process outgrowth of oligodendrocytes is promoted by interaction of fyn kinase with the cytoskeletal protein tau". J. Neurosci. 22 (3): 698–707. doi:10.1523/JNEUROSCI.22-03-00698.2002. PMID 11826099.

[pmid9648856-22] Iwasaki Y, Gay B, Wada K, Koizumi S (July 1998). "Association of the Src family tyrosine kinase Fyn with TrkB". J. Neurochem. 71 (1): 106–11. doi:10.1046/j.1471-4159.1998.71010106.x. PMID 9648856.

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ن ب و آنزیم‌ها
فعالیت	جایگاه فعال جایگاه اتصال سه‌گانه کاتالیزگر Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme کوآنزیم کوفاکتور کاتالیز آنزیم
قواعد	دگرریختاری Cooperativity بازدارنده آنزیم فعال‌کننده آنزیم
دسته‌بندی	عدد گروه آنزیم ابرخانواده آنزیم خانواده آنزیم فهرست آنزیم‌ها
سینتیک	سینتیک میکائلیس–منتن طرح ادی هوفستی طرح لاینویور برک طرح هانس وولف
انواع	ای‌سی۱ اکسیدوردوکتازها (فهرست) ای‌سی۲ ترانسفرازها (فهرست) ای‌سی۳ هیدرولازها (فهرست) ای‌سی۴ لیازها (فهرست) ای‌سی۵ ایزومرازها (فهرست) ای‌سی۶ لیگازها (فهرست) ای‌سی۷ ترنسلوکازها (فهرست)