پروتئین آرآبی۲۷آ

RAB27A
معین‌کننده‌ها
نام‌های دیگر	RAB27A, GS2, HsT18676, RAB27, RAM, member RAS oncogene family
شناسه‌های بیرونی	OMIM: 603868 MGI: 1861441 HomoloGene: 3069 GeneCards: RAB27A
موقعیت ژن (موش)
کروموزوم	کروموزوم ۹ (موش)
پایان	73,004,911 bp
الگوی گسترش RNA
	; ; ; ;
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• nucleotide binding; • protein domain specific binding; • GDP binding; • GTP binding; • myosin V binding; • GO:0001948، GO:0016582 پیوند پروتئینی; • GO:0006184 GTPase activity;
ترکیبات سلولی	• جسم وایبل-پالاد; • اندوزوم; • late endosome; • دستگاه گلژی; • multivesicular body membrane; • exocytic vesicle; • secretory granule membrane; • membrane; • melanosome; • photoreceptor outer segment; • secretory granule; • دندریت; • apical plasma membrane; • کافنده‌تن; • extracellular exosome; • extracellular region; • سیتوزول; • melanosome membrane; • specific granule lumen; • سیناپس;
فرایند زیستی	• positive regulation of reactive oxygen species biosynthetic process; • natural killer cell degranulation; • protein targeting; • positive regulation of phagocytosis; • antigen processing and presentation; • multivesicular body sorting pathway; • pigment granule localization; • انعقاد خون; • melanosome localization; • pigment granule transport; • GO:1901313 positive regulation of gene expression; • multivesicular body organization; • melanosome transport; • positive regulation of constitutive secretory pathway; • synaptic vesicle transport; • complement-dependent cytotoxicity; • pigmentation; • cytotoxic T cell degranulation; • exosomal secretion; • positive regulation of exocytosis; • melanocyte differentiation; • vesicle-mediated transport; • positive regulation of regulated secretory pathway; • اگزوسیتوز; • neutrophil degranulation; • intracellular protein transport; • Rab protein signal transduction;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	5873
	11891
	ENSG00000069974
	ENSMUSG00000032202
	P51159
	Q9ERI2
	NM_004580، NM_183234، NM_183235، NM_183236، XM_005254576، XM_011521852، XM_011521854، XM_011521855، XM_024450009 XM_011521856، NM_004580، NM_183234، NM_183235، NM_183236، XM_005254576، XM_011521852، XM_011521854، XM_011521855، XM_024450009
	NM_001301232، NM_023635، XM_006510780 NM_001301230، NM_001301232، NM_023635، XM_006510780
	NP_899057، NP_899058، NP_899059، XP_005254633، XP_011520154، XP_011520156، XP_011520157، XP_011520158، XP_024305777 NP_004571، NP_899057، NP_899058، NP_899059، XP_005254633، XP_011520154، XP_011520156، XP_011520157، XP_011520158، XP_024305777
	NP_001288161، NP_076124، XP_006510843 NP_001288159، NP_001288161، NP_076124، XP_006510843
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

پروتئین Rab-27A مرتبط با Ras (انگلیسی: Ras-related protein Rab-27A) یک پروتئین است که در انسان توسط ژن «RAB27A» کُدگذاری می‌شود.^[۴]^[۵]

پروتئین یادشده، متعلق به خانوادهٔ پروتئین‌های Rab است که خود، جزئی از اَبَـرخانوادهٔ «جی‌تی‌پی‌آزهای کوچک» هستند. ژن «RAB27A» توسط فاکتور رونویسی مرتبط با میکروفتالمی تنظیم می‌شود.^[۶]^[۷]

منابع

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000032202 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Seabra MC, Ho YK, Anant JS (Dec 1995). "Deficient geranylgeranylation of Ram/Rab27 in choroideremia". J Biol Chem. 270 (41): 24420–7. doi:10.1074/jbc.270.41.24420. PMID 7592656.
↑ "Entrez Gene: RAB27A RAB27A, member RAS oncogene family".
↑ Chiaverini C, Beuret L, Flori E, Busca R, Abbe P, Bille K, Bahadoran P, Ortonne JP, Bertolotto C, Ballotti R (2008). "Microphthalmia-associated transcription factor regulates RAB27A gene expression and controls melanosome transport". J. Biol. Chem. 283 (18): 12635–42. doi:10.1074/jbc.M800130200. PMID 18281284.
↑ Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.

مشارکت‌کنندگان ویکی‌پدیا. «RAB27A». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۳ ژوئن ۲۰۲۰.

برای مطالعهٔ بیشتر

Nagata K, Itoh H, Katada T, Takenaka K, Ui M, Kaziro Y, Nozawa Y (1989). "Purification, identification, and characterization of two GTP-binding proteins with molecular weights of 25,000 and 21,000 in human platelet cytosol. One is the rap1/smg21/Krev-1 protein and the other is a novel GTP-binding protein". J. Biol. Chem. 264 (29): 17000–5. PMID 2507536.
Chen D, Guo J, Miki T, Tachibana M, Gahl WA (1997). "Molecular cloning and characterization of rab27a and rab27b, novel human rab proteins shared by melanocytes and platelets" (PDF). Biochem. Mol. Med. 60 (1): 27–37. doi:10.1006/bmme.1996.2559. PMID 9066979.
Tolmachova T, Ramalho JS, Anant JS, Schultz RA, Huxley CM, Seabra MC (1999). "Cloning, mapping and characterization of the human RAB27A gene". Gene. 239 (1): 109–16. doi:10.1016/S0378-1119(99)00371-6. PMID 10571040.
Ménasché G, Pastural E, Feldmann J, Certain S, Ersoy F, Dupuis S, Wulffraat N, Bianchi D, Fischer A, Le Deist F, de Saint Basile G (2000). "Mutations in RAB27A cause Griscelli syndrome associated with haemophagocytic syndrome". Nat. Genet. 25 (2): 173–6. doi:10.1038/76024. PMID 10835631.
Hu RM, Han ZG, Song HD, Peng YD, Huang QH, Ren SX, Gu YJ, Huang CH, Li YB, Jiang CL, Fu G, Zhang QH, Gu BW, Dai M, Mao YF, Gao GF, Rong R, Ye M, Zhou J, Xu SH, Gu J, Shi JX, Jin WR, Zhang CK, Wu TM, Huang GY, Chen Z, Chen MD, Chen JL (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
Haddad EK, Wu X, Hammer JA, Henkart PA (2001). "Defective granule exocytosis in Rab27a-deficient lymphocytes from Ashen mice". J. Cell Biol. 152 (4): 835–42. doi:10.1083/jcb.152.4.835. PMC 2195776. PMID 11266473.
Bahadoran P, Aberdam E, Mantoux F, Buscà R, Bille K, Yalman N, de Saint-Basile G, Casaroli-Marano R, Ortonne JP, Ballotti R (2001). "Rab27a: A key to melanosome transport in human melanocytes". J. Cell Biol. 152 (4): 843–50. doi:10.1083/jcb.152.4.843. PMC 2195788. PMID 11266474.
Xu XR, Huang J, Xu ZG, Qian BZ, Zhu ZD, Yan Q, Cai T, Zhang X, Xiao HS, Qu J, Liu F, Huang QH, Cheng ZH, Li NG, Du JJ, Hu W, Shen KT, Lu G, Fu G, Zhong M, Xu SH, Gu WY, Huang W, Zhao XT, Hu GX, Gu JR, Chen Z, Han ZG (2002). "Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver". Proc. Natl. Acad. Sci. U.S.A. 98 (26): 15089–94. doi:10.1073/pnas.241522398. PMC 64988. PMID 11752456.
Kuroda TS, Fukuda M, Ariga H, Mikoshiba K (2002). "The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain". J. Biol. Chem. 277 (11): 9212–8. doi:10.1074/jbc.M112414200. PMID 11773082.
Fukuda M, Kuroda TS, Mikoshiba K (2002). "Slac2-a/melanophilin, the missing link between Rab27 and myosin Va: implications of a tripartite protein complex for melanosome transport". J. Biol. Chem. 277 (14): 12432–6. doi:10.1074/jbc.C200005200. PMID 11856727.
Yi Z, Yokota H, Torii S, Aoki T, Hosaka M, Zhao S, Takata K, Takeuchi T, Izumi T (2002). "The Rab27a/granuphilin complex regulates the exocytosis of insulin-containing dense-core granules". Mol. Cell. Biol. 22 (6): 1858–67. doi:10.1128/MCB.22.6.1858-1867.2002. PMC 135591. PMID 11865063.
Strom M, Hume AN, Tarafder AK, Barkagianni E, Seabra MC (2002). "A family of Rab27-binding proteins. Melanophilin links Rab27a and myosin Va function in melanosome transport". J. Biol. Chem. 277 (28): 25423–30. doi:10.1074/jbc.M202574200. PMID 11980908.
Wu X, Wang F, Rao K, Sellers JR, Hammer JA (2002). "Rab27a is an essential component of melanosome receptor for myosin Va". Mol. Biol. Cell. 13 (5): 1735–49. doi:10.1091/mbc.01-12-0595. PMC 111140. PMID 12006666.
Kuroda TS, Fukuda M, Ariga H, Mikoshiba K (2002). "Synaptotagmin-like protein 5: a novel Rab27A effector with C-terminal tandem C2 domains". Biochem. Biophys. Res. Commun. 293 (3): 899–906. doi:10.1016/S0006-291X(02)00320-0. PMID 12051743.
Anikster Y, Huizing M, Anderson PD, Fitzpatrick DL, Klar A, Gross-Kieselstein E, Berkun Y, Shazberg G, Gahl WA, Hurvitz H (2002). "Evidence that Griscelli syndrome with neurological involvement is caused by mutations in RAB27A, not MYO5A". Am. J. Hum. Genet. 71 (2): 407–14. doi:10.1086/341606. PMC 379173. PMID 12058346.
Nagashima K, Torii S, Yi Z, Igarashi M, Okamoto K, Takeuchi T, Izumi T (2002). "Melanophilin directly links Rab27a and myosin Va through its distinct coiled-coil regions". FEBS Lett. 517 (1–3): 233–8. doi:10.1016/S0014-5793(02)02634-0. PMID 12062444.
Torii S, Zhao S, Yi Z, Takeuchi T, Izumi T (2002). "Granuphilin modulates the exocytosis of secretory granules through interaction with syntaxin 1a". Mol. Cell. Biol. 22 (15): 5518–26. doi:10.1128/MCB.22.15.5518-5526.2002. PMC 133943. PMID 12101244.
Wistow G, Bernstein SL, Wyatt MK, Fariss RN, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K (2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants". Mol. Vis. 8: 205–20. PMID 12107410.
Barral DC, Ramalho JS, Anders R, Hume AN, Knapton HJ, Tolmachova T, Collinson LM, Goulding D, Authi KS, Seabra MC (2002). "Functional redundancy of Rab27 proteins and the pathogenesis of Griscelli syndrome". J. Clin. Invest. 110 (2): 247–57. doi:10.1172/JCI15058. PMC 151050. PMID 12122117.

این یک مقالهٔ خرد زیست‌شناسی مولکولی است. می‌توانید با گسترش آن به ویکی‌پدیا کمک کنید.

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000032202 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7592656-4] Seabra MC, Ho YK, Anant JS (Dec 1995). "Deficient geranylgeranylation of Ram/Rab27 in choroideremia". J Biol Chem. 270 (41): 24420–7. doi:10.1074/jbc.270.41.24420. PMID 7592656.

[entrez-5] "Entrez Gene: RAB27A RAB27A, member RAS oncogene family".

[pmid18281284-6] Chiaverini C, Beuret L, Flori E, Busca R, Abbe P, Bille K, Bahadoran P, Ortonne JP, Bertolotto C, Ballotti R (2008). "Microphthalmia-associated transcription factor regulates RAB27A gene expression and controls melanosome transport". J. Biol. Chem. 283 (18): 12635–42. doi:10.1074/jbc.M800130200. PMID 18281284.

[pmidunknown-7] Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.

[۱]

[۲]

[۳]

[۴]

[۵]

[۶]

[۷]