1 motako kanabinoide errezeptore

CNR1
Egitura erabilgarria
PDB	Ortologoaren bilaketa: PDBe RCSB
PDB ID kodeen zerrenda
	1LVQ, 1LVR, 2B0Y, 2KOE, 2MZ3, 2MZ2, 2MZA,%%s1LVQ, 1LVR, 2B0Y, 2KOE
Identifikatzaileak
Aliasak	CNR1 (HUGO), CANN6, CB-R, CB1, CB1A, CB1K5, CB1R, CNR, cannabinoid receptor 1 (brain), cannabinoid receptor 1, cannabinoid CB1 receptor gene
Kanpoko IDak	OMIM: 114610 MGI: 104615 HomoloGene: 7273 GeneCards: CNR1 OMA: CNR1 - orthologs
Drogaren xedea
	HU-210 , win 55212-2 , anandamide , cannabinol , Tetrahidrocannabinol, Org27569 , LY-320135 , rimonabant , TM-38837
Genearen kokapena (gizakia)
	Kromosoma: 6 (gizakia)
Amaiera	88.166.347 bp
Genearen kokapena (sagua)
	Kromosoma: 4 (sagua)
Amaiera	33.948.831 bp
RNA adierazpen eredua
	Adierazpen ohikoena
	ganglionic eminence ; ; ventricular zone ; ; Dezidua; ; cerebellar vermis ; ; paraflocculus of cerebellum ; ; frontal pole ; ; Region I of hippocampus proper ; ; Brodmann area 10 ; ; Brodmann area 23 ; ; endothelial cell ;
	Adierazpen ohikoena
	lobe of cerebellum ; ; cerebellar vermis ; ; subiculum ; ; ventromedial nucleus ; ; lateral hypothalamus ; ; anterior amygdaloid area ; ; dentate gyrus of hippocampal formation granule cell ; ; lateral septal nucleus ; ; superior frontal gyrus ; ; deep cerebellar nuclei ;
	Erreferentziazko adierazpen datu gehiago
	Erreferentziazko adierazpen datu gehiago
Gene ontologia
Funtzio molekularra	G proteina errezeptore akoplatuaren aktibitatea ; seinaleen transdukzio aktibitatea ; cannabinoid receptor activity ; proteina lotura ; voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels ;
Zelularen osagaia	zelula-mintzaren osagai integrala ; intracellular membrane-bounded organelle ; mintza ; growth cone ; plasma-mintzaren osagai integrala ; Axoi ; lipido baltsa ; zelula mintz ; presynaptic membrane ; mitokondrio ; mitochondrial outer membrane ; cell projection ; integral component of mitochondrial membrane ; presynapse ; glutamatergic synapse ; GABA-ergic synapse ; integral component of presynaptic membrane ;
Prozesu biologikoa	negative regulation of nitric-oxide synthase activity ; negative regulation of mast cell activation ; glucose homeostasis ; response to nutrient ; regulation of insulin secretion ; negative regulation of blood pressure ; adenylate cyclase-modulating G protein-coupled receptor signaling pathway ; maternal process involved in female pregnancy ; G proteina errezeptore akoplatuaren komunikazio bidea, nukleotide ziklikoaren bigarren mezulariari akoplatua ; response to nicotine ; giza zahartze ; positive regulation of fever generation ; Oroimen ; negative regulation of action potential ; regulation of feeding behavior ; negative regulation of ion transport ; response to morphine ; negative regulation of fatty acid beta-oxidation ; response to lipopolysaccharide ; positive regulation of blood pressure ; regulation of penile erection ; regulation of lipid metabolic process ; Espermatogenesi ; positive regulation of neuron projection development ; positive regulation of apoptotic process ; positive regulation of acute inflammatory response to antigenic stimulus ; learning or memory ; Nozizepzio ; negative regulation of dopamine secretion ; regulation of synaptic transmission, glutamatergic ; response to ethanol ; axonal fasciculation ; regulation of synaptic transmission, GABAergic ; seinale transdukzio ; response to cocaine ; trans-synaptic signaling by endocannabinoid, modulating synaptic transmission ; G proteina errezeptore akoplatuaren komunikazio bidea ; cannabinoid signaling pathway ; retrograde trans-synaptic signaling by endocannabinoid ; positive regulation of presynaptic cytosolic calcium concentration ; induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration ;
	Iturburuak: : Amigo / QuickGO
Ortologoak
	1268
	12801
	ENSG00000118432
	ENSMUSG00000044288
	P21554
	P47746
	NM_001160226; NM_001160258; NM_001160259; NM_001160260; NM_016083; NM_033181; NM_001365869; NM_001365870; NM_001365872; NM_001365874; NM_001370545; NM_001370546; NM_001370547
	NM_007726; NM_001355020; NM_001355021; NM_001365881
	NP_001153698; NP_001153730; NP_001153731; NP_057167; NP_149421; NP_001352798; NP_001352799; NP_001352801; NP_001352803; NP_001357474; NP_001357475; NP_001357476
	NP_031752; NP_001341949; NP_001341950; NP_001352810
	Wikidata
Ikusi/Editatu giza genea	Ikusi/Editatu saguaren genea

1 motako kanabinoide errezeptorea (CB₁) G proteinari akoplatutako kanabinoide errezeptore bat da, gizakiengan CNR1 geneak kodetzen duena. Gizakien CB1 errezeptorea nerbio-sistema periferikoan eta nerbio-sistema zentralean agertzen da^[6]. Aktibatzen duten konposatuen artean daude: endokanabinoideak, anandamida eta 2-arakidonoilglizerola bezala neurotransmisore erretrogradoak dituen talde bat; landareen fitokanabinoideak, adibidez THCa, kanabis drogaren osagai aktibo nagusia dena; eta THCaren anaologo sintetikoak. CB1 tetrahidrokanabibarinak (THCV) antagonizatzen du^[7]^[8].

Gizakiengan, anandamida da errezeptore honen barne agonista nagusia.

Erreferentziak

↑ Fisikoki elkarreragiten duten drogak 1 motako kanabinoide errezeptoreikusi/editatu erreferentziak Wikidatan. .
↑ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000118432 - Ensembl, May 2017
↑ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000044288 – Ensembl, May 2017
↑ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ «CB1 receptor | Cannabinoid receptors | IUPHAR/BPS Guide to PHARMACOLOGY» www.guidetopharmacology.org (Noiz kontsultatua: 2020-09-07).
↑ (Ingelesez) Pertwee, R. G.; Thomas, A.; Stevenson, L. A.; Ross, R. A.; Varvel, S. A.; Lichtman, A. H.; Martin, B. R.; Razdan, R. K.. (2007). «The psychoactive plant cannabinoid, Δ9-tetrahydrocannabinol, is antagonized by Δ8- and Δ9-tetrahydrocannabivarin in mice in vivo» British Journal of Pharmacology 150 (5): 586–863. doi:10.1038/sj.bjp.0707124. ISSN 1476-5381. PMID 17245367. PMC PMC2189766. (Noiz kontsultatua: 2020-09-07).^{[Betiko hautsitako esteka]}
↑ (Ingelesez) Thomas, Adèle; Stevenson, Lesley A.; Wease, Kerrie N.; Price, Martin R.; Baillie, Gemma; Ross, Ruth A.; Pertwee, Roger G.. (2005). «Evidence that the plant cannabinoid Δ9-tetrahydrocannabivarin is a cannabinoid CB1 and CB2 receptor antagonist» British Journal of Pharmacology 146 (7): 917–926. doi:10.1038/sj.bjp.0706414. ISSN 1476-5381. PMID 16205722. PMC PMC1751228. (Noiz kontsultatua: 2020-09-07).^{[Betiko hautsitako esteka]}

Kanpo estekak

Datuak: Q21201294
Multimedia: Cannabinoid receptor 1 / Q21201294

[1] Fisikoki elkarreragiten duten drogak 1 motako kanabinoide errezeptoreikusi/editatu erreferentziak Wikidatan. .

[refGRCh38Ensembl-2] GRCh38: Ensembl release 89: ENSG00000118432 - Ensembl, May 2017

[refGRCm38Ensembl-3] GRCm38: Ensembl release 89: ENSMUSG00000044288 – Ensembl, May 2017

[4] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[6] «CB1 receptor | Cannabinoid receptors | IUPHAR/BPS Guide to PHARMACOLOGY» www.guidetopharmacology.org (Noiz kontsultatua: 2020-09-07).

[7] (Ingelesez) Pertwee, R. G.; Thomas, A.; Stevenson, L. A.; Ross, R. A.; Varvel, S. A.; Lichtman, A. H.; Martin, B. R.; Razdan, R. K.. (2007). «The psychoactive plant cannabinoid, Δ9-tetrahydrocannabinol, is antagonized by Δ8- and Δ9-tetrahydrocannabivarin in mice in vivo» British Journal of Pharmacology 150 (5): 586–863. doi:10.1038/sj.bjp.0707124. ISSN 1476-5381. PMID 17245367. PMC PMC2189766. (Noiz kontsultatua: 2020-09-07).^{[Betiko hautsitako esteka]}

[8] (Ingelesez) Thomas, Adèle; Stevenson, Lesley A.; Wease, Kerrie N.; Price, Martin R.; Baillie, Gemma; Ross, Ruth A.; Pertwee, Roger G.. (2005). «Evidence that the plant cannabinoid Δ9-tetrahydrocannabivarin is a cannabinoid CB1 and CB2 receptor antagonist» British Journal of Pharmacology 146 (7): 917–926. doi:10.1038/sj.bjp.0706414. ISSN 1476-5381. PMID 16205722. PMC PMC1751228. (Noiz kontsultatua: 2020-09-07).^{[Betiko hautsitako esteka]}

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