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Protein-coding gene in the species Homo sapiens
Exportin-T is a protein that in humans is encoded by the XPOT gene .[ 5] [ 6] [ 7]
This gene encodes a protein belonging to the RAN-GTPase exportin family that mediates export of tRNA from the nucleus to the cytoplasm. Translocation of tRNA to the cytoplasm occurs once exportin has bound both tRNA and GTP-bound RAN.[ 7]
^ a b c GRCh38: Ensembl release 89: ENSG00000184575 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034667 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Kutay U, Lipowsky G, Izaurralde E, Bischoff FR, Schwarzmaier P, Hartmann E, Gorlich D (Jul 1998). "Identification of a tRNA-specific nuclear export receptor" . Mol Cell . 1 (3): 359– 69. doi :10.1016/S1097-2765(00)80036-2 PMID 9660920 . 359- 69&rft.date=1998-07&rft_id=info:doi/10.1016/S1097-2765(00)80036-2&rft_id=info:pmid/9660920&rft.aulast=Kutay&rft.aufirst=U&rft.au=Lipowsky, G&rft.au=Izaurralde, E&rft.au=Bischoff, FR&rft.au=Schwarzmaier, P&rft.au=Hartmann, E&rft.au=Gorlich, D&rft_id=https://doi.org/10.1016%2FS1097-2765%2800%2980036-2&rfr_id=info:sid/en.wikipedia.org:XPOT" class="Z3988">^ Arts GJ, Fornerod M, Mattaj IW (May 1998). "Identification of a nuclear export receptor for tRNA" . Curr Biol . 8 (6): 305– 14. doi :10.1016/S0960-9822(98)70130-7 PMID 9512417 . S2CID 17803674 . 305- 14&rft.date=1998-05&rft_id=https://api.semanticscholar.org/CorpusID:17803674#id-name=S2CID&rft_id=info:pmid/9512417&rft_id=info:doi/10.1016/S0960-9822(98)70130-7&rft.aulast=Arts&rft.aufirst=GJ&rft.au=Fornerod, M&rft.au=Mattaj, IW&rft_id=https://doi.org/10.1016%2FS0960-9822%2898%2970130-7&rfr_id=info:sid/en.wikipedia.org:XPOT" class="Z3988">^ a b "Entrez Gene: XPOT exportin, tRNA (nuclear export receptor for tRNAs)" .
Arts GJ, Kuersten S, Romby P, et al. (1999). "The role of exportin-t in selective nuclear export of mature tRNAs" . EMBO J . 17 (24): 7430– 41. doi :10.1093/emboj/17.24.7430 . PMC 1171087 PMID 9857198 . 7430- 41&rft.date=1999&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1171087#id-name=PMC&rft_id=info:pmid/9857198&rft_id=info:doi/10.1093/emboj/17.24.7430&rft.aulast=Arts&rft.aufirst=GJ&rft.au=Kuersten, S&rft.au=Romby, P&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1171087&rfr_id=info:sid/en.wikipedia.org:XPOT" class="Z3988">Kruse C, Willkomm DK, Grünweller A, et al. (2000). "Export and transport of tRNA are coupled to a multi-protein complex" . Biochem. J . 346 (1): 107– 15. doi :10.1042/0264-6021:3460107 . PMC 1220829 PMID 10657246 . 107- 15&rft.date=2000&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1220829#id-name=PMC&rft_id=info:pmid/10657246&rft_id=info:doi/10.1042/0264-6021:3460107&rft.aulast=Kruse&rft.aufirst=C&rft.au=Willkomm, DK&rft.au=Grünweller, A&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1220829&rfr_id=info:sid/en.wikipedia.org:XPOT" class="Z3988">Kutay U, Hartmann E, Treichel N, et al. (2001). "Identification of two novel RanGTP-binding proteins belonging to the importin beta superfamily" . J. Biol. Chem . 275 (51): 40163– 8. doi :10.1074/jbc.M006242200 hdl :11858/00-001M-0000-0015-3D4E-B PMID 11024021 . 40163- 8&rft.date=2001&rft_id=info:hdl/11858/00-001M-0000-0015-3D4E-B&rft_id=info:pmid/11024021&rft_id=info:doi/10.1074/jbc.M006242200&rft.aulast=Kutay&rft.aufirst=U&rft.au=Hartmann, E&rft.au=Treichel, N&rft_id=https://doi.org/10.1074%2Fjbc.M006242200&rfr_id=info:sid/en.wikipedia.org:XPOT" class="Z3988">Kuersten S, Arts GJ, Walther TC, et al. (2002). "Steady-state nuclear localization of exportin-t involves RanGTP binding and two distinct nuclear pore complex interaction domains" . Mol. Cell. Biol . 22 (16): 5708– 20. doi :10.1128/MCB.22.16.5708-5720.2002 . PMC 133969 PMID 12138183 . 5708- 20&rft.date=2002&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC133969#id-name=PMC&rft_id=info:pmid/12138183&rft_id=info:doi/10.1128/MCB.22.16.5708-5720.2002&rft.aulast=Kuersten&rft.aufirst=S&rft.au=Arts, GJ&rft.au=Walther, TC&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC133969&rfr_id=info:sid/en.wikipedia.org:XPOT" class="Z3988">Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899– 903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . 16899- 903&rft.date=2003&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241#id-name=PMC&rft_id=info:pmid/12477932&rft_id=info:doi/10.1073/pnas.242603899&rft_id=info:bibcode/2002PNAS...9916899M&rft.aulast=Strausberg&rft.aufirst=RL&rft.au=Feingold, EA&rft.au=Grouse, LH&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241&rfr_id=info:sid/en.wikipedia.org:XPOT" class="Z3988">Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121– 7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . 2121- 7&rft.date=2004&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928#id-name=PMC&rft_id=info:pmid/15489334&rft_id=info:doi/10.1101/gr.2596504&rft.aulast=Gerhard&rft.aufirst=DS&rft.au=Wagner, L&rft.au=Feingold, EA&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928&rfr_id=info:sid/en.wikipedia.org:XPOT" class="Z3988">Suzuki T, Koyama Y, Hayakawa S, et al. (2006). "1,25-Dihydroxyvitamin D3 suppresses exportin expression in human promyelocytic leukemia HL-60 cells" . Biomed. Res . 27 (2): 89– 92. doi :10.2220/biomedres.27.89 PMID 16707848 . 89- 92&rft.date=2006&rft_id=info:doi/10.2220/biomedres.27.89&rft_id=info:pmid/16707848&rft.aulast=Suzuki&rft.aufirst=T&rft.au=Koyama, Y&rft.au=Hayakawa, S&rft_id=https://doi.org/10.2220%2Fbiomedres.27.89&rfr_id=info:sid/en.wikipedia.org:XPOT" class="Z3988">Li S, Sprinzl M (2007). "Interaction of immobilized human exportin-t with calf liver tRNA" . RNA Biol . 3 (4): 145– 9. doi :10.4161/rna.3.4.3679 PMID 17224653 . 145- 9&rft.date=2007&rft_id=info:doi/10.4161/rna.3.4.3679&rft_id=info:pmid/17224653&rft.aulast=Li&rft.aufirst=S&rft.au=Sprinzl, M&rft_id=https://doi.org/10.4161%2Frna.3.4.3679&rfr_id=info:sid/en.wikipedia.org:XPOT" class="Z3988">
