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WDR36

From Wikipedia, the free encyclopedia
WDR36
Identifiers
AliasesWDR36, GLC1G, TA-WDRP, TAWDRP, UTP21, WD repeat domain 36
External IDsOMIM: 609669; MGI: 1917819; HomoloGene: 6536; GeneCards: WDR36; OMA:WDR36 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_139281

NM_001110015
NM_001110016
NM_144863

RefSeq (protein)

NP_644810

n/a

Location (UCSC)Chr 5: 111.09 – 111.13 MbChr 18: 32.97 – 33 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

WD repeat-containing protein 36 is a protein that in humans is encoded by the WDR36 gene.[5][6][7]

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Mutations in this gene have been associated with adult-onset primary open-angle glaucoma (POAG).[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000134987Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038299Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Bernstein KA, Gallagher JE, Mitchell BM, Granneman S, Baserga SJ (Dec 2004). "The small-subunit processome is a ribosome assembly intermediate". Eukaryot Cell. 3 (6): 1619–26. doi:10.1128/EC.3.6.1619-1626.2004. PMC 539036. PMID 15590835.
  6. ^ Monemi S, Spaeth G, DaSilva A, Popinchalk S, Ilitchev E, Liebmann J, Ritch R, Heon E, Crick RP, Child A, Sarfarazi M (Mar 2005). "Identification of a novel adult-onset primary open-angle glaucoma (POAG) gene on 5q22.1". Hum Mol Genet. 14 (6): 725–33. CiteSeerX 10.1.1.542.5801. doi:10.1093/hmg/ddi068. PMID 15677485.
  7. ^ a b "Entrez Gene: WDR36 WD repeat domain 36".

Further reading

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